A5046758954- Animal testing and alternatives
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Health and Medical Research Impacts
- Entomological Studies and Ecology
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Plant and fungal interactions
- Asthma and respiratory diseases
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Aging and Gerontology Research
- Turfgrass Adaptation and Management
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- Mast cells and histamine
- Viral-associated cancers and disorders
Medical Research Council
2017-2020
Cardiff University
2020
Emory University
1988-1991
University College London
1986-1987
Northwick Park Hospital
1985
University of Virginia
1985
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting vital to this process; it allows readers assess reliability findings repeat or build upon work other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 help authors journals identify minimum information necessary report publications describing vivo experiments. Despite widespread endorsement by scientific community, impact on...
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has...
Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines were originally developed in 2010 to improve the reporting of animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour, and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been inconsistent, anticipated improvements quality...
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting animal research. They consist a checklist information include publications describing vivo experiments enable others scrutinise work adequately, evaluate its methodological rigour and reproduce methods results. Despite considerable levels endorsement by funders journals over years, adherence has been...
Peripheral blood mononuclear cells (PBMC) from the majority of allergic patients that we tested who were skin test-sensitive to house dust mite Dermatophagoides pteronyssinus (D. pt.) (46/67) showed significant proliferation in response purified major allergen Antigen P1; PBMC 14/15 nonsensitive controls no response. Optimal responses seen with 10 micrograms P1/ml, but 21 43 at 0.01 microgram P1/ml. The results three types experiments responding T cells, predominantly helper phenotype....
Abstract Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers assess reliability findings, repeat or build upon work other researchers. The NC3Rs developed ARRIVE guidelines in 2010 help authors journals identify minimum information necessary report publications describing vivo experiments. Despite widespread endorsement by scientific community, impact on transparency animal has been...
Early region E3 of adenovirus (Ad) appears to encode proteins involved in the interaction virus with host immune system. The 19-kDa glycoprotein (gp19K) binds class I MHC Ag endoplasmic reticulum and inhibits their transport cell surface; it has been proposed that this protects infected cells from lysis by CTL. We have found 14.7-kDa protein (14.7K) TNF, here we show also lymphotoxin, which implicated as a mediator CTL lysis. developed method for producing specific human Ad2 Ad5 mice, order...
As part of the studies to establish an international reference preparation <i>Dermatophagoides pteronyssinus </i>allergens, ten coded extracts this mite were assessed in four laboratories. The compared for total potency using direct RAST, RAST inhibition and quantitative skin tests, also composition major allergen content crossed immunoelectrophoresis, radioimmunoelectrophoresis, rocket immunoelectrophoresis radioimmunoassay. In addition, source materials examined by light...
In 2010, the NC3Rs published Animal Research: Reporting of Vivo Experiments (ARRIVE) guidelines to improve reporting animal research. Despite considerable levels support from scientific community, impact on quality in research publications has been limited. This position paper highlights strategy an expert working group established revise and facilitate their uptake. The group's initial work will focus three main areas: prioritisation ARRIVE items into a tiered system, development...
Abstract The Ag specificity and MHC restriction of the CTL response to adenovirus 5 (Ad5) in three strains mice, C57BL/10 (H-2b), BALB/c (H-2d), C3H/HeJ (H-2k), were tested. Polyclonal Ad5-specific prepared by priming mice vivo with live Ad5 virus followed secondary vitro stimulation spleen cells virus-infected syngeneic cells. Db restricted Kk C3H/HeJ. In both Kd- Dd/Ld-restricted detected. polyclonal is directed exclusively against products E1A region, which comprises only 5% genome. at...
Growth and differentiation of B cells is thought to be regulated by soluble factors derived from T cells. However, human cell lines hybridomas have proved notoriously unreliable unstable sources such factors. We report here that three stable bladder carcinoma T24, RT4 5637 produce, in a constitutive fashion, which promote growth
Summary ‘Spontaneous’ improvement in, or alteration of, allergic symptoms is a common occurrence, and the immunological basis of interest in attempts to develop effective specific therapy. In present study we measured levels serum antibodies Dermatophagoides pteronyssinus patients diagnosed as having house‐dust‐allergic asthma up 40 years previously. The results show progressive fall both IgG IgE antigen P 1 RAST binding lo crude D. extract. By contrast changes total were not marked. Within...
Objectives To evaluate compliance by researchers with funder requirements on clinical trial transparency, including identifying key areas for improvement; to assess the completeness, accuracy and suitability annual monitoring of data routinely collected a research funding body. Design Descriptive analysis trials funded between February 2011 January 2017 against policy requirements. Setting Public medical body in UK. Data sources Relevant were identified from grant application details,...
The CTL response to SV40 in C3H/HeJ mice is directed against the tumor (T) Ag and H-2Kk restricted. specific for both amino terminus (residues 1-271) carboxyl 512-708) of T molecule have been detected, we previously cloned specificities. In this paper show that panel 10 clones C-terminal region includes three different epitopes, termed C1, C2, C3. Epitopes C1 C2 are conserved related papova viruses BK SA12, only epitopes C3 present on transformed targets bearing Kk mutant Kkml. were mapped...