A5026152677- Optical measurement and interference techniques
- Image Processing Techniques and Applications
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Gene expression and cancer classification
- Animal Nutrition and Physiology
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Advanced Measurement and Metrology Techniques
- Polymer crystallization and properties
- Epigenetics and DNA Methylation
- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Photonic and Optical Devices
- Advanced Vision and Imaging
- Manufacturing Process and Optimization
- Semiconductor Lasers and Optical Devices
- Pluripotent Stem Cells Research
- Gene Regulatory Network Analysis
- RNA and protein synthesis mechanisms
- Atherosclerosis and Cardiovascular Diseases
- 3D IC and TSV technologies
- Advanced X-ray Imaging Techniques
- Organic Light-Emitting Diodes Research
Guangxi Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Hunan Agricultural University
2023-2024
University of Michigan
2019-2024
Beihang University
2024
Ann Arbor Center for Independent Living
2024
Queen Mary University of London
2024
Zhengzhou Central Hospital
2024
Zhejiang University
2011-2023
Toronto Metropolitan University
2023
Abstract Many single-cell sequencing technologies are now available, but it is still difficult to apply multiple the same single cell. In this paper, we propose an unsupervised manifold alignment algorithm, MMD-MA, for integrating measurements carried out on disjoint aliquots of a given population cells. Effectively, MMD-MA performs in silico co-assay by embedding cells measured different ways into learned latent space. data points from domains aligned optimizing objective function with...
Abstract Genomic Knowledgebase (GenomicKB) is a graph database for researchers to explore and investigate human genome, epigenome, transcriptome, 4D nucleome with simple efficient queries. The uses knowledge consolidate genomic datasets annotations from over 30 consortia portals, including 347 million entities, 1.36 billion relations, 3.9 entity relation properties. GenomicKB equipped web-based query system (https://gkb.dcmb.med.umich.edu/) which allows users the customized patterns specific...
Background Perivascular epithelioid cell tumours (PEComas) occurring in the uterus are rare, with surgery being most recommended primary treatment for malignant cases. This study aims to provide clinical guidance on clinicopathological features and appropriate options patients uterine PEComas of uncertain potential. Cases case series summarises courses 13 diagnosed potential, including pathological data as well their outcomes. We identified one at our hospital, other 12 cases were extracted...
The genus Alternaria, functioning as a saprobe, endophyte, and plant pathogen, is widely distributed across various natural human-impacted environments. Leaf spot black diseases, caused by Alternaria species, are the most prevalent diseases within this genus, leading to significant reductions in crop yields substantial economic losses. To facilitate timely detection of species during early stages infection, enable targeted treatments, mitigate associated damages, we employed identification...
The potential of 5-aminolevulenic acid (ALA) to enhance the salt tolerance cucumber (Cucumis sativus L.) seedlings was investigated. ALA applied at various concentrations (0, 1, 10, 25, 50, and 100 mg dm-3) as foliar spray or root watering. Then were exposed 0 75 mM NaCl for 5 d. stress reduced leaf dry masses, area, net CO2 assimilation rate. These reductions counteracted by exogenous ALA, most efficient 50 dm-3 concentration via spray. decreased H2O2 contents increased activities ascorbate...
PurposeCurrent therapies for proliferative diabetic retinopathy (PDR) do not specifically target VEGF-independent, cell-type specific processes that lead to vision loss, such as inflammatory pathways. This study aims identify targetable cell types, and corresponding signaling pathways, by elucidating the single landscape of vitreous patients with PDR.DesignCase SeriesSamplesVitreous peripheral blood obtained from five adult (six eyes) undergoing pars plana vitrectomy vision-threatening...
Knowledge graphs have recently emerged as a powerful data structure to organize biomedical knowledge with explicit representation of nodes and edges. The is in machine-learning ready format supports explainable AI models. However, PubMed, the largest richest repository, exists free text, limiting its utility for advanced machine learning tasks. To address limitation, we present LiteralGraph, computational framework that rigorously extracts terms relationships from PubMed literature. Using...
How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, essential member of the MLL chromatin modifying complex, that regulates mouse stem fate. Wild-type Wdr5 or transient knockout promotes distinct pattern global accessibility spurs neuroectodermal differentiation through RbBP5-dependent process in which...
To assess the effects of inactivated Lactobacillus rhamnosus (ILR) on growth performance, serum biochemical indices, colonic microbiota, and metabolomics in weaned piglets, 120 piglets were randomly divided into five groups. Samples control group fed a basal diet, while experimental ILR1, ILR2, ILR3, ILR4 groups diets supplemented with 0.1%, 0.2%, 0.3%, 0.4% ILR, respectively. The prefeeding period lasted for 5 days was followed by formal 28 days.
Quantitative phase extraction is a key step in optical measurement. While shifting technique widely employed for static or semi-static measurement, it requires several images with known shifts at each deformed stage, thus not suitable dynamic Fourier transform offer solution to extract information from single fringe pattern. However, high frequency spatial carrier which sometimes easy generate required solve the ambiguity problem. In this paper, we aim propose an ideal Four shift are...
A temporal wavelet analysis method is proposed for velocity, displacement, and three-dimensional surface-profile measurement of a continuously deforming object by use the shadow moiré technique. grating placed close to object, its observed through grating. The fringe patterns, generated interference lines their shadows, are captured high-speed CCD camera with telecentric gauging lens. Instantaneous frequency gray-value variation evaluated point continuous transform. From instantaneous each...
With rapid advancements in technologies involving genetic testing, epigenomic and transcriptomic profiling, many landmark consortia have generated rich multimodal data for the human genome. Among those, focused on pancreas islet research greatly enhanced our understanding of different forms diabetes. Despite new insights provided at an unprecedented scale depth, current are fragmented across portals with lack common metadata/ontology standards, varying maturity quality control pipelines,...
This study aimed to investigate the correlation between expression of Ki67 and FasL prognosis cervical carcinoma explore biological processes signal pathways related carcinoma. Cervical tissue specimens from 200 patients normal adjacent lesions 30 cases were collected in this study. proteins these detected by immunohistochemical methods. A series statistical methods carried out The tissues was significantly higher than that tissue. positive rate increased with increase degree lesions. There...
Recently the active-matrix organic light-emitting diode (AMOLED) has emerged as a very promising flat-panel display technology because of its potential widely application for development high resolution and flexible full color flat panel displays. However, encapsulation AMOLED is studied developed due to top-emission structure used in AMOLED. Different from bottom-emission structure, requests light escaping device through transparent moisture barrier layer. In this paper, we investigate...
(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way solve current dilemma industry. (2) Methods: assess effects a fermented Chinese herbal (FCH) formula on immunity growing pigs, 100 Duroc × Landrace Yorshire three-way crossed pigs were randomly divided into control treatment groups that fed basal diet, diet with 1% (group A), 2% B), 3% C) FCH formulas, respectively. A sixty-day formal experiment was conducted, their...
p53 alterations occur during culture of pluripotent stem cells (PSCs), but the significance these events on epigenetic control PSC fate determination remains poorly understood. Wdr5 deletion in p53-null (DKO) mouse ESCs (mESCs) leads to impaired self-renewal, defective retinal neuroectoderm differentiation, and de-repression germ cell/meiosis (GCM)-specific genes. Re-introduction a WDR5 mutant with H3K4 methylation activity into DKO restored self-renewal suppressed GCM gene expression failed...
<h3>Background</h3> Life-expectancy is increasing in the western-world. Unfortunately, lifespan does not coincide with health-span. Older people (≥60 years) are living longer chronic illnesses such as asthma. Increasing age associated profound changes immune system including immunosenescence and inflammageing resulting increased incidence severity of infections, well other diseases. Yet despite these dramatic immunity, impact on severe asthma phenotype function understood. The majority...