A5015935971- Hydrogels: synthesis, properties, applications
- Supramolecular Self-Assembly in Materials
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Lipid Membrane Structure and Behavior
- Polysaccharides Composition and Applications
- Nanocomposite Films for Food Packaging
- Advanced Cellulose Research Studies
- Proteoglycans and glycosaminoglycans research
- Proteins in Food Systems
- Nanomaterials for catalytic reactions
- Polymer Surface Interaction Studies
- Bee Products Chemical Analysis
- Aerogels and thermal insulation
- Protein Interaction Studies and Fluorescence Analysis
- Polymer composites and self-healing
- Surfactants and Colloidal Systems
- Microencapsulation and Drying Processes
- Polydiacetylene-based materials and applications
- Botanical Studies and Applications
Institutul de Chimie Macromoleculară Petru Poni
2021-2025
Romanian Academy
2017-2025
Grigore T. Popa University of Medicine and Pharmacy
2023
Gheorghe Asachi Technical University of Iași
2013-2017
Institute of Macromolecular Chemistry
2017
Alexandru Ioan Cuza University
2015
Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called next generation drug delivery systems due to their relatively high encapsulation capacity, uniformity, tunable size, ease preparation, minimal toxicity, stability the presence serum, stimuli responsiveness. show a great potential chemotherapy, diagnosis, organ targeting bioactive substances. The main subjects reviewed this...
Development of natural protein-based hydrogels with self-healing performance and tunable physical properties has attracted increased attention owing to their wide potential not only in the pharmaceutical field, but also wounds management. This work reports development a versatile hydrogel based on enzymatically-crosslinked gelatin nanogels loaded amoxicillin (Amox), an antibiotic used wound infections. The transglutaminase (TGase)-crosslinked encapsulating were formed rapidly through...
Introduction Polymer nanogels are among the most promising nanoplatforms for use in biomedical applications. The substantial interest these drug carriers is to enhance transportation of bioactive substances, reduce side effects, and achieve optimal action on curative sites by targeting delivery triggering release drugs a controlled continuous mode.
Nowadays, large amounts of wastewater arise from various industrial applications. The discharge into the environment represents a threat to aquatic ecosystem and human health. Thus, in present study, innovative double-network (DN) hydrogels with pH-sensitive features applicability as adsorbents treatment leather dye were prepared. polyelectrolyte, poly(N,N-dimethylaminoethyl methacrylate (PDMAEMA), was obtained via radical polymerization process, while supramolecular structure co-assembled...
Owing to its antibacterial, anti-inflammatory, and antioxidant activities, in the last few years, lavender essential oil (LVO) has been used medical applications as a promising approach for treating infected wounds. However, practical applicability of LVO is limited by high volatility storage stability. This study aimed develop novel hybrid hydrogel combining phytic acid (PA)-crosslinked sodium alginate (SA) poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane (PITAU)...
The purpose of the study is to obtain multicomponent polyelectrolyte hydrogels with optimal synergistic properties by combining a modified starch synthetic one. Thus, new low-cost and biocompatible semi-interpenetrating polymer network (semi-IPN) carboxymethyl poly(2-dimethylaminoethyl methacrylate) are prepared investigated. synthesized studied respect specific characteristics gels: swelling kinetics, thermal analysis, viscoelastic characteristics, their ability be used as matrix in drug...
Bio-based compounds are a leading direction in the context of increased demand for these materials due to numerous advantages associated with their use over conventional materials, which hardly degrade environment. At same time, essential oils and components is generated mainly by finding alternative solutions antibiotics synthetic preservatives bioactive characteristics, but also synergistic capacity during manifestation different biological properties. The present study devoted...
Hydrogels based on natural, biodegradable materials have gained considerable interest in the medical field due to their improved drug delivery profiles and tissue-mimicking architecture. In this regard, study was devoted preparation characterization of new physically crosslinked hydrogels carboxymethyl cellulose an unconventional crosslinking agent, phytic acid. Phytic acid, addition its antioxidant antibacterial effects, can improve biological properties stability gels, without adding...
The study presents the development of a new copolymacrolactone structure based on ethylene brassylate (EB) and squaric acid (SA) with different ratios between comonomers. system was tested as network for essential oils encapsulation. copolymers confirmed by spectroscopic investigations correlated in interdependence comonomers content. interfacial characteristics poly(ethylene brassylate-co-squaric acid) were determined, transition from moderate hydrophilic surface towards hydrophobic region...
Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications. Thus, the physicochemical properties investigated correlated with composition of new structures. Dynamic light scattering measurements, transmission electron microscopy images, demonstrated that size distribution was narrow average diameter between 186 246 nm, presented positive zeta potential values. The sensitivity at pH temperature also evaluated....
Protein-polysaccharide systems are of increasing interest as their combined attributes allow for fulfilling a broad range applications in biomedical and pharmaceutical fields. In this study, the preparation nanogels based on maleic anhydride chitosan derivatives (MAC) bovine serum albumin (BSA) was achieved through self-assembly process performed aqueous phase. A series experiments by varying concentrations MAC BSA were conducted to find an appropriate mixing ratio polymer solutions leading...
Short aromatic peptide derivatives, i.e., peptides or amino acids modified with groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture. Among different types of acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors the proper growth cells, carnitine production, collagen formation. The authors have previously successfully presented possibility...