A5023413944- Ion channel regulation and function
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Genomics and Phylogenetic Studies
- Cholesterol and Lipid Metabolism
- Photosynthetic Processes and Mechanisms
- HIV/AIDS drug development and treatment
- Ion-surface interactions and analysis
- Telomeres, Telomerase, and Senescence
- Cancer Immunotherapy and Biomarkers
- Plant Stress Responses and Tolerance
- Ion Channels and Receptors
- CRISPR and Genetic Engineering
- Diabetes Treatment and Management
- Immune Cell Function and Interaction
- Carbohydrate Chemistry and Synthesis
- Advanced Materials Characterization Techniques
- DNA Repair Mechanisms
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Fibroblast Growth Factor Research
23andMe (United States)
2024
Amgen (United States)
2020
Duke University Hospital
2012-2016
Duke Medical Center
2012-2016
Duke University
2012-2014
Institute of Biomedical Sciences, Academia Sinica
2005
Moving Bricks with MraY Peptidoglycan, the building brick of bacterial cell walls, is synthesized in cytoplasm and must be transported across membrane. To achieve this, it attached to a carrier lipid by integral membrane protein MraY. targeted natural antibacterials promising antibiotic target. Chung et al. (p. 1012 ) report crystal structure at 3.3 Å resolution. The structure, together mutational mapping, outlines location active site provides interesting hints for how enzyme binds...
Details of intestinal sterol absorption and inhibition by cholesterol-lowering drug are uncovered in new protein structures.
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism believed to offer therapeutic potential for various metabolic diseases. Pharmacological intervention of GIPR, however, has limited success due lack effective antagonistic reagents. Previously we reported the discovery two mouse anti-murine GIPR monoclonal antibodies (mAbs) with distinctive properties rodent models. Here, report detailed...
Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. Blockade of CD200R1-dependent signaling enhances cell-mediated antitumor activity in vitro vivo. 23ME-00610 is potential first-in-class, humanized IgG1 investigational antibody that binds hCD200R1 with high affinity. We have previously shown inhibits checkpoint function. Herein, we dissect molecular...
The Phospho‐MurNAc‐pentapeptide translocase (MraY) is a membrane‐spanning enzyme involved in an essential process of bacterial cell wall synthesis: transfer the peptidoglycan precursor phosphor‐MurNAc‐pentapeptide to carrier lipid undecaprenyl phosphate. MraY belongs subfamily polyprenyl‐phosphate N‐acetyl hexosamine 1‐phosphate transferase (PNPT) superfamily whose members are various biological processes including prokaryotic envelope polymer synthesis and eukaryotic N‐linked glycosylation....