A5063677294- Cancer-related cognitive impairment studies
- Cancer survivorship and care
- Health, psychology, and well-being
- Glioma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Circular RNAs in diseases
- Family Support in Illness
- Tryptophan and brain disorders
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Advanced machining processes and optimization
- Neuropeptides and Animal Physiology
- Cardiac and Coronary Surgery Techniques
- Heart Rate Variability and Autonomic Control
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammasome and immune disorders
- Dementia and Cognitive Impairment Research
Anhui Medical University
2022-2024
Fujian Medical University
2020-2024
Second Affiliated Hospital of Fujian Medical University
2020-2024
Second Hospital of Anhui Medical University
2022-2024
New York University
2019
Shenyang Jianzhu University
2018
Chinese People's Liberation Army
2016
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
1993
Chinese Academy of Medical Sciences & Peking Union Medical College
1993
Breast cancer is one of the significant threats to women's health worldwide, and traditional treatment methods have many limitations. Liposomes, as a novel type nanocarrier for drugs, attracted widespread attention due their unique structural functional advantages. This paper provides detailed introduction composition preparation liposomes, well diverse applications in breast treatment, including conventional long-circulating thermosensitive pH-sensitive ligand-modified liposomes. It also...
BACKGROUND:Myocardial ischemia mediates the progression of multiple cardiovascular diseases and leads to serious damage morphology, function, metabolism cardiomyocytes. The serum level hormone Meteorin-like (METRNL) was lower in patients with coronary artery disease negatively correlated inflammatory cytokines. aim present study determine relationship between METRNL myocardial ischemia/reperfusion (MI/R) injury, investigate molecular mechanisms implicated pathogenesis ischemia. MATERIAL AND...
Chemotherapy related cognitive impairment (CRCI) is a type of memory and induced by chemotherapy has become growing clinical problem. Breast cancer survivors (BCs) refer to patients from the moment breast diagnosis end their lives. Managing Cancer Living Meaningfully (CALM) convenient easy-to-apply psychological intervention that been proven improve quality life alleviate CRCI in BCs. However, underlying neurobiological mechanisms remain unclear. Resting-state functional magnetic resonance...
Breast cancer is one of the most common cancers in women worldwide. Tamoxifen (TAM) provided a successful treatment for ER-positive (ER+) breast many years. However, ER+ patients with metastatic diseases respond poorly to TAM therapy and initial responders eventually relapse. Emerging evidence indicates that long non-coding RNAs (lncRNAs) may have critical role regulation cellular processes such as progression metastasis, though function lncRNAs TAM-resistance still unclear. To investigate...
The role of Hsa_circ_0001445 in oxidation Low Lipoprotein (ox-LDL) induced HUVEC inflammatory damage remains poorly characterized. present study investigated the performance circRNA on ox-LDL-induced damage. ox-LDL was employed to treat HUVECs and expression cells were detected by qRT-PCR. Then, overexpression plasmid circ_0001445 transfected into HUVECs. Cell Counting Kit-8 assay performed detect cell viability, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β IL-6 treatment measured...
Objective: To evaluate the effects of managing cancer and living meaningfully (CALM), a psychological intervention with semi-structured interviews, on cancer-related fatigue (CRF), quality life (QOL), sleep in patients gastrointestinal (GI) cancer, which may be accompanied by changes cytokine levels. Methods: A total 152 GI CRF were enrolled study during treatment. Patients randomly assigned to CALM or usual care (UC) groups. group received 12 weeks plus care, UC health education. All...
Previous findings indicated that polymorphism in gene catechol-O-methyltransferase (COMT) had been linked to chemotherapy-related cognitive impairment (CRCI). Nevertheless, the motivation of COMT polymorphisms regulating breast cancer survivors with disparate status human epidermal growth factor receptor 2 (HER2) was still vague.The current research aimed evaluate regulation risk by genotype on CRCI HER2.Breast (103 HER2- and 118 HER2+) underwent neuropsychological tests before after...
Background Previous reports have suggested that coronary computed tomography angiography (CCTA)-based radiomics analysis is a potentially helpful tool for assessing vulnerable plaques. We aimed to investigate whether radiomic of CCTA images could identify plaques in patients with stable angina pectoris. Methods This retrospective study included initially diagnosed Patients were randomly divided into either the training or test dataset at an 8 : 2 ratio. Radiomics features extracted from...
Copper-induced cell death (cuproptosis) is a new regulatory mechanism. Long noncoding RNAs (lncRNAs) are related to tumor immunity and metastasis. However, the correlation of cuproptosis-related lncRNAs with immunotherapy response prognosis lung adenocarcinoma (LUAD) patients not clear.We obtained clinical characteristics transcriptome data from TCGA-LUAD dataset (containing 539 LUAD 59 paracancerous tissues). By utilizing LASSO-penalized Cox regression analysis, we identified prognostic...
Fear of cancer recurrence (FCR) and psychological distress are common problems in breast (BC) patients ultimately affecting their health-related quality life (HRQoL). Heart rate variability (HRV) can reflect the activity parasympathetic nervous system. However, pathways through which HRV influences between FCR HRQoL unclear. This study preliminarily explored intermediary role BC patients.A total 101 participated this study. parameters were measured by a 5-min dynamic electrocardiogram. FCR,...
Endothelial cell damage induced by oxidized low-density lipoprotein (ox-LDL) plays an important role in the pathogenesis of atherosclerosis (AS). We aimed to explore effects lysophosphatidic acid receptor 5 (LPAR5) on ox-LDL-induced human umbilical vein endothelial cells (HUVECs). After HUVECs exposed ox-LDL, LPAR5 expression was detected RT-qPCR and western blotting. Then, silenced viability determined with a CCK-8 assay. ELISA employed analyze contents inflammatory factors. The levels...
Aim: To evaluate the effectiveness of Managing Cancer and Living Meaningfully (CALM) in esophageal cancer with psychological distress during treatment. Materials & methods: The study assigned eligible patients to either a CALM group or usual care group. Psychological distress, anxiety, depression quality life scores were assessed for both groups at baseline, intervention period end intervention. Results: Patients showed significant reduction anxiety demonstrated improved after intervention,...
<title>Abstract</title> <bold>Background and Objectives:</bold> The protracted treatment of colorectal cancer often leads to diminished quality life the manifestation psychological symptoms, notably depression, as patient survival increases. Behavioral Activation (BA) therapy is designed bolster patients' reinforcement sources diminish avoidance behaviors, thereby progressively fostering proactive engagement. This study aims assess influence BA on behavioral patterns patients, its...
To explore the role of perceived social support in enhancing psychological resilience and quality life postoperative breast cancer patients.
Background: CD4+ memory T cells (CD4+ MTCs), as an important part of the microenvironment affecting tumorigenesis and progression, have rarely been systematically analyzed. Our purpose was to comprehensively analyze effect MTC infiltration on prognosis colon adenocarcinoma (COAD). Methods: Based RNA-Seq data, weighted gene co-expression network analysis (WGCNA) used screen genes most associated with cancer then identify hub construct a prognostic model using least absolute shrinkage...
Abstract Background Chemotherapy‐related cognitive impairment (CRCI) is a common but easily overlooked condition that markedly affects the quality of life (QOL) patients with breast cancer. The rs671 gene polymorphism aldehyde dehydrogenase 2 ( ALDH2 ) in Asia involved metabolism and may be closely related to CRCI. However, no study has yet summarised association between Methods This enrolled one hundred twenty‐four diagnosed cancer according pathology results, genotyped for...
Background and aims: Neuropeptide Y (NPY) is associated with endothelial dysfunction. This study explored the relationship between NPY acute myocardial infarction (AMI). Materials methods: We included 128 AMI cases 62 controls. Using SYNTAX scoring system, group was subgrouped into “SYNTAX≤22,” “SYNTAX=23–32,” “SYNTAX≥33.” Plasma NPY, endothelin, nitric oxide synthase (eNOS), thromboxane A2 (TXA2) levels were determined.Results: The had higher plasma TXA2 than controls ([58.76±17.63 vs....