A5070268660- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Antibiotics Pharmacokinetics and Efficacy
- Medication Adherence and Compliance
- Photoreceptor and optogenetics research
- Blood Pressure and Hypertension Studies
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Pharmaceutical Practices and Patient Outcomes
- Gestational Diabetes Research and Management
- Drug Transport and Resistance Mechanisms
- Reproductive System and Pregnancy
- Memory and Neural Mechanisms
- Birth, Development, and Health
- Botulinum Toxin and Related Neurological Disorders
- Pregnancy and preeclampsia studies
- Neurological disorders and treatments
- Analytical Chemistry and Chromatography
University Hospital Galway
2005-2024
Ollscoil na Gaillimhe – University of Galway
2003-2007
Galway Clinic
2005
University College London
1996-2002
National Hospital for Neurology and Neurosurgery
1996-2002
University of Birmingham
2001
University of Leeds
2000-2001
Boston University
2001
Heidelberg University
2001
University Hospital Heidelberg
2001
Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks. Network modeling predicts that such synchrony depends in part on the fast time course of excitatory postsynaptic potentials (EPSPs) interneurons, and even moderate slowing this will disrupt synchrony. We generated mice with slowed interneuron EPSPs by gene targeting, which encoding 67-kDa form glutamic acid decarboxylase (GAD67) was...
An isocratic high performance liquid chromatographic micromethod is described for the quantitation of levetiracetam (ucb L059) in plasma or serum patients. The chromatography performed on a 250 x 4 mm I.D. LiChrospher 60 RP-select B, 5-micron column, eluted with an acetonitrile/50 mM phosphate buffer (15:85 vol/vol, pH 5.6) mobile phase, and detected using ultraviolet absorbance at 220 nm. limit was 5 mumol/L within-batch between-batch coefficients variation were < 7%. No interference from...
Brief tetanic stimulation (eight pulses at 100 Hz) of afferent fibers innervating area CAI the hippocampus produce gamma oscillations. When delivered every minute oscillation habituated markedly after first stimulus. This habituation could be transiently reversed by stimulating a different pathway to recorded area. Gamma oscillation-induced beta frequency oscillations were only seen in response (novel) stimulus and itself was attenuated on-going, non-oscillogenic, synaptic activity. The NMDA...
Introduction: Gestational diabetes (GDM), defined as hyperglycemia with onset or initial recognition during pregnancy, has a rising prevalence paralleling the rise in type 2 (T2DM) and obesity. GDM is associated short-term long-term consequences for both mother child. Therefore, it crucial we efficiently identify all cases initiate early treatment, reducing fetal exposure to GDM-related adverse pregnancy outcomes. For this reason, screening recommended part of routine care. The current...
The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms which are unknown. large conductance calcium-activated K+ channel (BKCa) ubiquitously encountered tissue and plays a significant role modulating myometrial cell membrane excitability. objective this study was to investigate involvement BKCa function response cells hCG. Single...
Gamma frequency oscillations occur in hippocampus <i>in vitro</i> after brief tetani delivered to afferent pathways. Previous reports have characterized these as either (1) trains of GABA<sub>A</sub> inhibitory synaptic events mediated by depolarization both pyramidal cells and interneurons at least part metabotropic glutamate acetylcholine receptors, or (2) field potential occurring the near absence an oscillation when are driven depolarizing GABA responses local synchrony is produced...
Context: β3-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role modulating cell membrane potential and excitability. Objective: This study was designed investigate the involvement of BKCa channel function response β3-adrenoceptor activation. Design: Single whole-cell electrophysiological recordings from freshly dispersed myocytes were obtained presence absence BRL37344, specific...
The tetanus toxin seizure model, which is associated with spontaneous and intermittent generalized non‐generalized seizures, considered to reflect human complex partial epilepsy. purpose of the present study was investigate compare anticonvulsant effects carbamazepine that levetiracetam, a new anti‐epileptic drug in this model. One μl solution (containing 12 mLD 50 −1 toxin) placed stereotactically into rat left hippocampus resulting seizures. Carbamazepine (4 mg kg h ) levetiracetam (8 16...
Hypertension, or high blood pressure, is a key modifiable risk factor for heart disease and stroke. International guidelines have highlighted 'poor adherence to treatment' 'physician inertia' as major barriers effective pressure management. The Maximising Adherence, Minimising Inertia (MIAMI) intervention, theory-based complex supports General Practitioners (GPs) people with hypertension in maximising medication use manage pressure. This pilot cluster randomised control trial (RCT) aimed...
Using a newly developed microdialysis probe which allows continuous monitoring of drugs in blood, we have studied the pharmacokinetics various antiepileptic (carbamazepine, and its primary metabolite carbamazepine-epoxide, phenytoin primidone phenobarbitone) 5 patients (2 male, 3 female, aged 40-50 years) with intractable epilepsy. It was observed that microdialysate pharmacokinetic profiles were comparable to those obtained by direct blood sampling. Furthermore, found highly acceptable...
PGF2alpha exerts a significant contractile effect on myometrium and is central to human labour. THG113.31, specific non-competitive receptor (FP) antagonist, an inhibitory myometrial contractility. The BKCa channel ubiquitously encountered in uterine tissue plays role modulating cell membrane potential excitability. objective of this study was investigate involvement the response THG113.31. Single whole-cell electrophysiological recordings from freshly dispersed myocytes, were investigated...