A5060558126- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Bacterial Identification and Susceptibility Testing
- Cutaneous Melanoma Detection and Management
- Vibrio bacteria research studies
- RNA regulation and disease
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
- Urticaria and Related Conditions
- Blood disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Genetic and rare skin diseases.
- Biotin and Related Studies
- Melanoma and MAPK Pathways
- Oral and gingival health research
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Autoimmune Bullous Skin Diseases
University College London
2023-2025
The Francis Crick Institute
2023-2025
Institute of Child Health
2023
Great Ormond Street Hospital
2023
CNR de la Résistance aux Antibiotiques
2018-2021
Université Paris-Saclay
2020
Université Paris-Sud
2020
Institut Pasteur
2020
Assistance Publique – Hôpitaux de Paris
2020
Mosaic variants in genes GNAQ or GNA11 lead to a spectrum of vascular and pigmentary diseases including Sturge-Weber syndrome, which progressive post-natal neurological deterioration led us seek biologically-targeted therapeutics. Using two cellular models we find here that disease-causing GNAQ/11 hyperactivate constitutive GPCR ligand-induced intracellular calcium signalling endothelial cells. We go on show the aberrant ligand-activated signal is fuelled by extracellular influx through CRAC...
In Enterobacter cloacae complex (ECC), the overproduction of chromosome-encoded cephalosporinase (cAmpC) associated with decreased outer membrane permeability may result in carbapenem resistance. this study, we have characterized ACT-28, a cAmpC weak carbapenemase activity, from single kobei lineage.
A novel real-time multiplex PCR assay, BD MAX Check-Points CPO, was evaluated to detect carbapenemase-producing organisms in clinical settings on the system. total of 175 well-characterized isolates (including 123 carbapenemase producers) and 128 rectal swab specimens 83 positives) patients considered at high risk for carriage producers were included. Bacterial suspensions used spike true-negative swabs mimic a sample. Sample (50 μL), containing either spiked or patient's sample, processed....
Among children with multiple congenital melanocytic nevi, 25% have no established genetic cause, of whom many develop a hyperproliferative and severely pruritic phenotype resistant to treatment. Gene fusions been reported in individual cases nevi. We studied 169 patients nevi this study, 38 were double wild type for pathogenic NRAS/BRAF variants. Nineteen these had sufficient tissue undergo RNA sequencing, which revealed mosaic BRAF 11 19 RAF1 1 19. Recurrently, involved the loss 5´...
RAS proteins regulate cell division, differentiation, and apoptosis through multiple downstream effector pathways. Oncogenic variants are the commonest drivers in cancers; however, they also drive many benign lesions predisposing to malignancy, such as melanocytic nevi, thyroid nodules, colonic polyps. Reversal of these could reduce cancer incidence; effects oncogenic have been notoriously difficult target with pathway inhibitors. In this study, we show effective suppression currently...
A carbapenem-resistant Citrobacter sp. was recovered from routine screening of multidrug-resistant bacteria. This isolate coproduced OXA-48 and OXA-198. carried by the prototypical IncL plasmid, whereas OXA-198 a peculiar IncHI-type plasmid. carbapenemase gene inserted within class 1 integron located on conjugative report describes first occurrence in Enterobacterales .
The MAST® Carba PAcE test is a colorimetric used to detect carbapenemase-producing Gram-negative bacilli from cultured colonies. performances of this were compared β-CARBA™, NP and RAPIDEC® CARBA tests using collection 280 characterized isolates. Sensitivity specificity the 79.8% (95%IC: 73.3%-85.1%) 98.9% 92.9%-99.9%). sensitivity was lowest mainly due interpretation difficulties (particularly OXA-48-like).
Abstract Severe cases of congenital melanocytic naevi (CMN) are associated with substantial cutaneous and neurological morbidity an excess childhood mortality from melanoma. Effective treatments lacking. This mosaic disorder is caused most commonly by a heterozygous oncogenic variant NRAS c.181C>A, p.(Q61K). As has multiple downstream effectors we have sought to treat this disease precision genetic therapy rather than pathway inhibition, hypothesising that silencing the allele may...