A5030946507- Colorectal Cancer Treatments and Studies
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Genomics and Rare Diseases
- Antimicrobial Resistance in Staphylococcus
- Medicinal Plants and Bioactive Compounds
- Bone Metabolism and Diseases
- Ion channel regulation and function
- Hepatitis C virus research
- vaccines and immunoinformatics approaches
- Tryptophan and brain disorders
- Biomarkers in Disease Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- HIV/AIDS Research and Interventions
- Eicosanoids and Hypertension Pharmacology
- Metabolomics and Mass Spectrometry Studies
- Seaweed-derived Bioactive Compounds
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- HIV/AIDS drug development and treatment
- Cardiac electrophysiology and arrhythmias
Emory University
2021-2025
Tianjin University of Traditional Chinese Medicine
2024
China Agricultural University
2024
Emory and Henry College
2023
Abstract Background The ALVAC/gp120 + MF59 vaccines in the HIV Vaccine Trials Network (HVTN) 702 efficacy trial did not prevent human immunodeficiency virus-1 (HIV-1) acquisition. Vaccine-matched immunological endpoints that were correlates of HIV-1 acquisition risk RV144 measured HVTN and evaluated as Methods Among 1893 female vaccinees, 60 HIV-1–seropositive cases matched seronegative noncases sampled. HIV-specific CD4+ T-cell binding antibody responses 2 weeks after fourth fifth...
Poor penetration of many anti-tuberculosis (TB) antibiotics into the central nervous system (CNS) is thought to be a major driver morbidity and mortality in TB meningitis (TBM). While amount particular drug that crosses cerebrospinal fluid (CSF) varies from person person, little known about host factors associated with interindividual differences CSF concentrations anti-TB drugs. In patients diagnosed TBM country Georgia (n = 17), we investigate association between multiple including serum...
Background and objective The of this study was to investigate the potential salidroside (SAL) (a major active compound in Rhodiola rosea L.) regulating osteoclast differentiation function by modulating HIF-1 α pathway its downstream target genes. Methods expression genes examined at both mRNA protein levels osteoclasts treated with SAL. Immunofluorescence analysis performed assess nuclear translocation transcriptional activity response MTT, flow cytometry, qPCR, TRAP staining bone resorption...
Background: Obesity, a global disease, can lead to different chronic diseases and series of social health problems. Lifestyle changes, especially dietary are the most effective way treat obesity. Euglena, novel food, has attracted much attention. Previous studies have shown that Euglena is an important modulator host immune response. In this study, effects as nutritional intervention in high-fat-diet-induced obese C57BL/6J mice were investigated regarding adipose tissue accumulation lipid...
Abstract Despite substantial observational and experimental evidence that aspirin use can provide protection against the development of colorectal neoplasia, our understanding molecular mechanisms involved is inadequate limits ability to this drug effectively safely for chemoprevention. We employed an untargeted plasma metabolomics approach using liquid chromatography with high-resolution mass spectroscopy explore novel metabolites may contribute chemopreventive effects aspirin. Associations...
The majority of the single nucleotide variants (SNVs) identified by genome-wide association studies (GWAS) fall outside protein-coding regions. Elucidating functional implications these has been a major challenge. A possible mechanism for non-coding is that they disrupted canonical transcription factor (TF) binding sites affect in vivo TF. However, their impact varies since many positions within TF motif are not well conserved. Therefore, simply annotating all located putative may...
Supplementary Figure from Plasma Metabolomics Analysis of Aspirin Treatment and Risk Colorectal Adenomas
Supplementary Figure from Plasma Metabolomics Analysis of Aspirin Treatment and Risk Colorectal Adenomas
Abstract Poor penetration of many anti-tuberculosis (TB) antibiotics into the central nervous system (CNS) is thought to be a major driver morbidity and mortality in TB meningitis (TBM). While amount particular drug that crosses cerebrospinal fluid (CSF) varies from person person, little known about host factors associated with interindividual differences CSF concentrations anti-TB drugs. In patients diagnosed TBM country Georgia (n=17), we investigate association between multiple including...
<div>Abstract<p>Despite substantial observational and experimental evidence that aspirin use can provide protection against the development of colorectal neoplasia, our understanding molecular mechanisms involved is inadequate limits ability to this drug effectively safely for chemoprevention. We employed an untargeted plasma metabolomics approach using liquid chromatography with high-resolution mass spectroscopy explore novel metabolites may contribute chemopreventive effects...
<div>Abstract<p>Despite substantial observational and experimental evidence that aspirin use can provide protection against the development of colorectal neoplasia, our understanding molecular mechanisms involved is inadequate limits ability to this drug effectively safely for chemoprevention. We employed an untargeted plasma metabolomics approach using liquid chromatography with high-resolution mass spectroscopy explore novel metabolites may contribute chemopreventive effects...
Abstract Recent studies have indicated that it is possible to protect individuals from HIV infection using passive infusion of monoclonal antibodies. However, in order for antibodies confer robust protection, the must be capable neutralizing many strains virus. This particularly challenging context a highly diverse pathogen like HIV. It therefore great interest leverage existing observational data sources discover are able neutralize viruses via residues where show modest protection. Such...