A5043537109- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Ginger and Zingiberaceae research
- Pharmacogenetics and Drug Metabolism
- Mycobacterium research and diagnosis
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Ion Transport and Channel Regulation
- Gene Regulatory Network Analysis
- Folate and B Vitamins Research
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- DNA Repair Mechanisms
National Center for Toxicological Research
2015-2023
United States Food and Drug Administration
2015-2020
Qingdao University
2020
The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and etiology immunological diseases. In this study, we investigated whether expression TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located 3′‐untranslated region (3′‐UTR) gene via interactions microRNAs. Using a series silico assays, selected candidate microRNAs (miRNAs) potential to interact functional SNPs TAP2. SNP rs241456—located 3′‐UTR TAP2—resides...
Abstract The investigation of the complex processes involved in cellular differentiation must be based on unbiased, high throughput data processing methods to identify relevant biological pathways. A number bioinformatics tools are available that can generate lists pathways ranked by statistical significance (i.e. p-value), while ideally it would desirable functionally score relative each other or interacting parts system process. We describe a new computational method (Network Activity...
Abstract Drug-induced liver injury (DILI) is a leading cause of acute failure. Reliable and translational biomarkers are needed for early detection DILI. microRNAs (miRNAs) have received wide attention as novel class potential DILI biomarkers. However, it unclear how drugs other than acetaminophen may influence miRNA expression or which miRNAs could serve useful in humans. We selected ketoconazole (KCZ), classic hepatotoxin, to study proof concept workflow that integrated vivo, vitro,...
Recent studies have shown that microRNAs and long noncoding RNAs (lncRNAs) regulate the expression of drug metabolizing enzymes (DMEs) in human hepatic cells a set DMEs, including UDP glucuronosyltransferase (UGT) 2B15, is down-regulated dramatically liver by toxic acetaminophen (APAP) concentrations. In this study we analyzed mRNA, microRNA, lncRNA profiles APAP-treated HepaRG to explore RNA-dependent regulation DME expression. The UGT2B15 LINC00574 was decreased cells. levels were...
<b>Abstract ID 21867</b> <b>Poster Board 578</b> Ketoconazole, an imidazole derivative, is one of the treatment options used to treat Cushing's syndrome in adults and adolescents (>12-year-old) by suppressing steroidogenesis through its inhibition CYP17A1 (Cyp17a1 rodents), while a rare but life-threatening disease caused cortisol hypersecretion. It well known that microRNAs (miRNAs) influence drug metabolism regulating expression CYP enzymes. Our previous liver toxicity study has shown...
Noncoding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate gene expression in many physiological pathological processes, including drug metabolism. Drug metabolizing enzymes (DMES) are critical components drug‐induced liver toxicity. In this study, we used human hepatic HepaRG cells treated with 5 or 10 mM acetaminophen (APAP) our model system identified LINC00844 a toxicity‐associated lncRNA. We analyzed the profiles correlations between of key for metabolism...