A5079403263- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Parasitic Diseases Research and Treatment
- interferon and immune responses
- Antibiotics Pharmacokinetics and Efficacy
- Intraocular Surgery and Lenses
- Immune Cell Function and Interaction
- Ocular Infections and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- Cardiovascular Health and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Race, Genetics, and Society
- Ocular Diseases and Behçet’s Syndrome
- Bee Products Chemical Analysis
- Pain Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Pediatric Pain Management Techniques
Universidad de Guadalajara
2013-2025
Departamento de Salud
2021
Tecnológico de Monterrey
2019
Pontifícia Universidade Católica do Rio Grande do Sul
2019
Weatherford College
2019
Universidad Autónoma de Baja California
2019
Hospital Civil de Guadalajara
2019
Laboratorios Sophia (Mexico)
2016-2018
Mexican Social Security Institute
2015
Background: Cytogenotoxic damage caused by the consumption of legal and illegal drugs in drug abusers has been demonstrated, primarily due to alterations their antioxidant capacity, cellular repair mechanisms, increased production free radicals. Folic acid shows activity acting as a reducing agent, neutralizing present radicals, genomic damage. Methods: The intervention involved administering 15 mg folic acid, divided into three doses per day, group 44 abusers. frequency nuclear...
Objective To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment periodontitis in patients type 2 diabetes mellitus. Research design and methods In this double-blind, randomized clinical trial, total 42 chronic were included. Patients randomly assigned to either or three times day 7 days. Clinical determinations (probing depth, bleeding on probe, plaque index) performed extent severity before pharmacological...
Abstract Background Despite the development and application of vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around world, scientific community is still trying to find some therapies avoid or ameliorate fatal evolution disease 2019 (COVID-19). Since publication potential use ivermectin as a treatment disease, pleiad information about it has been published. However, evidence not strong weak enough conclude its usefulness in clinical patients infected with...
To evaluate the effect of avocado soybean unsaponifiables (ASU) on insulin secretion and sensitivity in patients with obesity.A randomized, double-blind, placebo-controlled, clinical trial was carried out 14 obese adult volunteers. After random allocation intervention, 7 received 300 mg ASU or placebo during a fasting state for 3 months. A metabolic profile including IL-6 high-sensitivity C-reactive protein (hs-CRP) levels prior to intervention. hyperglycemic-hyperinsulinemic clamp technique...
The aim of this study was to assess the effect continuous and intermittent electrical transcutaneous nerve stimulation on perception pain in patients with burns different types.A pilot conducted 14 (age 30.9±7.5 years) second- third-degree types. burn types included electrical, fire/flame, chemical. All received sessions three times per week for 4 weeks. Each session had a duration 30 minutes. A pair electrodes were placed around burn. primary efficacy endpoint assessed by visual analog...
Abstract Background Type 2 diabetes is more frequent in Latin American people than non-Hispanic whites due to a combination of genetic and lifestyle risk factors. Brazil Mexico are the most populous countries America. The present study aimed compare results National Health Survey “PNS” Nutrition “ENSANUT” regarding prevalence, complications healthcare issues both countries. Methods A cross-sectional was conducted with data from (PNS) 2013 (ENSANUT) 2018 Mexico. prevalence diabetes, factors...
The purpose of this study was to evaluate the aqueous humor bioavailability and clinical efficacy bromfenac 0.09% vs nepafenac on presence cystoid macular edema (CME) after phacoemulsification.A Phase II, double-blind, masked, active-controlled, multicenter, trial 139 subjects, randomized either a ophthalmic solution (n=69) or 0.1% (n=70). Subjects instilled drop three times day for period 30 days. Follow-up visits were days 2, 7, 15, 30, 60. Biomicroscopy, ocular signs, assessment posterior...
To determine the concentration after a single dose of generic 0.05% difluprednate and commercial in aqueous humor, cornea, conjunctiva New Zealand rabbits, preclinical study 72 male white rabbits was performed. A (50 μL) two ophthalmic formulations instilled both eyes. Conjunctiva, humor samples were collected at nine time points over 8 h (four animals per point). The active metabolite difluprednate, 17-difluoroprednisolone-butyrate (DFB), concentrations quantified using HPLC. Measurable...
There are different public databases and open access information that can be exploited to reused in research projects. With this concept mind, we carried out a study answer the question about prevalence of haplogroups human populations modern Mexico. Since publication genomic mitochondrial data Latin American very scarce with small samples, our work proposes consider availability genetic collections for other purposes, from those initially proposed investigations where sequences were...
Purpose: The purpose of this study was to evaluate the clinical efficacy and safety a novel ophthalmic solution pazufloxacin on ocular surface patients with bacterial conjunctivitis after 7 days intervention. Methods: This is phase 2, double-blind, controlled, multicenter, trial 300 subjects, randomized either 3 dosing regimen 0.6% (twice day [BID], n = 90; times [TID], 76; 4 [QID], 68), moxifloxacin 0.5% TID (n 82), or gatifloxacin 0.3% 72). Follow-up set 0, 3, 7. Assessments signs were...
Importance: Previous research showed that a twice-daily 108 mg dose of calcium fructoborate (CFB) improved knee discomfort during 2-week supplementation period. This current double-blind, placebo-controlled randomized study investigates the effects CFB on 90 days supplementation. Purpose: To evaluate comparative once-daily and dosing joint for ninety days. Design: 120 participants with self-reported were recruited into three groups (each N=40). Participants received: twice per day (CFB-G1);...
Type 2 diabetes has been linked to the expression of Human Leukocyte Antigens, principally major Histocompatibility Complex Class II and only scarce reports Major class I in specific populations. The objective present work was explore presence polymorphisms MHC related Mexican population using GWAS SIGMA database. This database contains information 3,848 individuals with type 4,366 control from same without clinical or hereditary history disease. searching criteria considered a P value...
Abstract Background Despite the development and application of vaccines against SARS-CoV-2 around world, scientific community still tried to find some therapies avoid or ameliorate fatal evolution COVID-19. Since publication potential use Ivermectin as a treatment disease, pleiad information about it has been published. However, evidence is not strong weak enough conclude its usefulness in clinical patients infected with SARS-CoV-2. We evaluate efficacy safety ivermectin Mexican asymptomatic...
Type 2 diabetes (T2D) has been linked to the expression of Human Leukocyte Antigens, principally Major Histocompatibility Complex Class II, with only scarce reports I in specific populations. The objective present work was explore presence polymorphisms MHC related T2D Mexican population using Genome-Wide Association Studies Slim Initiative Genomic Medicine Americas (GWAS SIGMA) database. This database contains information on 3848 individuals and 4366 control from same without a clinical or...
Single nucleotide polymorphisms in the mitochondrial genome have been investigated relation to breast cancer. Certain variants could be associated with an increased risk of this malignant disease. These associations underline importance function cancer biology and highlight potential for mtDNA-based biomarkers future therapies. The general objective research was develop a model which is capable identifying nonlinear patterns sequences. Association rules were used explore mtDNA variant...
Type 2 diabetes (T2D) is a chronic systemic disease with complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted secondary analysis of complete mtDNA sequences from 1,261 T2D patients 1,105 control individuals. Our findings revealed significant associations between certain single nucleotide polymorphisms (SNPs) T2D. Notably, the variants m.1438A>G (controls: 32 [27.6%], T2D: 84 [72.4%]; OR:...
Objective: The objective of the present study was to determine if body mass index and vitamin D levels are risk factors for development uterine leiomyomas in Mexican women. Methods: A cross-sectional designed. Inclusion criteria were women between 20 55 years with a suspect leiomyomas. Transvaginal ultrasonography made confirm diagnosis clinical variables collected. Vitamin measured serum by chemiluminescence immunoassay. Binary linear regression analysis conducted assess predictors Results:...
Abstract Background Breast cancer has a predominant incidence and prevalence in Caucasian women. Although alterations the mitochondrial genome probably play an important role carcinogenesis, actual evidence is ambiguous inconclusive. The purpose of present work was to determine frequency polymorphisms associated with breast exploring sequences clinical cases diagnosed from different origins reusing information available public free access database GenBank.Results 110 mtDNA were identified,...
El presente trabajo es un resumen de obesidad enfocado a la fisiopatología, diagnóstico y tratamiento, tiene como objetivo ofrecer las actualidades en investigación. En génesis se involucran factores relacionados al estilo vida, una dieta inadecuada, falta actividad física, cambios neuroendocrinos genética, principalmente. Esto provoca acumulación grasa visceral por ende obesidad, factor desencadenante enfermedades crónico-degenerativas, tales como: diabetes mellitus, dislipidemia,...
Breast cancer has an important incidence in the worldwide female population. Although alterations mitochondrial genome probably play role carcinogenesis, actual evidence is ambiguous and inconclusive. The purpose of present work was to explore sequences clinical cases with breast from different origins determine polymorphisms associated. search for complete partial mtDNA obtained patients controls performed NCBI Genbank database. We identified 124 associated which 86 were 38 sequences. Of...
Since the discovery of mitochondrial-derived peptides (MDP), their participation in cellular metabolism is no longer considered as sole function mitochondria, but importance was also attached to its role a source protective factors metabolic stress. These are encoded mitochondrial genome and translated into mitochondria or cytoplasm, signal within cell be released bind membrane receptors. The objective this work explored compare frequency MT-RNR1 MT-RNR2 variants sequences obtained from T2D...
Breast cancer has an important incidence in the worldwide female population. Although alterations mitochondrial genome probably play role carcinogenesis, actual evidence is ambiguous and inconclusive. Our purpose was to explore differences sequences of cases with breast compared control samples from different origins. We identified 124 mtDNA associated cases, which 86 were complete 38 partial sequences. Of these sequences, 52 belonged patients a confirmed diagnosis cancer, 34 obtained...