A5069393766- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Effects and risks of endocrine disrupting chemicals
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- Folate and B Vitamins Research
- Cardiovascular Issues in Pregnancy
- Biochemical and Structural Characterization
- Plant and fungal interactions
- Gene expression and cancer classification
- Histone Deacetylase Inhibitors Research
- Hair Growth and Disorders
- Neurological Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Chronic Kidney Disease and Diabetes
- Pomegranate: compositions and health benefits
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Gene Regulatory Network Analysis
Universidad de Guadalajara
2011-2024
Universidad Nacional Autónoma de México
2014
Background: Cytogenotoxic damage caused by the consumption of legal and illegal drugs in drug abusers has been demonstrated, primarily due to alterations their antioxidant capacity, cellular repair mechanisms, increased production free radicals. Folic acid shows activity acting as a reducing agent, neutralizing present radicals, genomic damage. Methods: The intervention involved administering 15 mg folic acid, divided into three doses per day, group 44 abusers. frequency nuclear...
Abstract Lung cancer is a malignant disease with increasing mortality rates. Cytokines play role in normal cell growth regulation and differentiation are also implicated disease. Among these cytokines, Transforming Growth Factor β type 1 (TGF‐β1) acts as tumor promoter cells. Several clinical studies have found high levels of TGF‐β1 various types. The aim this study was to establish cut‐off point complementary diagnostic tool lung detection. Therefore, 72 clinically well‐characterized...
Abstract Drug abuse is considered a global health problem with serious social impact. In recent decades, changes in drug consumption patterns have shown clear rising trend the use of multiple drugs. Although buccal micronucleus cytome (BMCyt) assay has evaluated cytotoxicity abuse, there not been an approach that takes into account this pattern use. Therefore, study, we evaluate for first time cytogenotoxic effects multidrug users, and its correlation amount consumed years abuse. This study...
Objective:The high global incidence of type 2 diabetes has challenged researchers to establish animal models that resemble the chronic stage observed in patients.One such model is induced by neonatal streptozotocin (n-STZ) administration rat pups at 0, 2, or 5 days after birth.In this study, we assessed Ins-1 gene expression and tissue insulin levels as well serum concentration glucose insulin, resistance, histological changes islets Langerhans n5-STZ rats 20-weeks post-induction.Methods:...
p53 regulates the cellular response to genotoxic damage and prevents carcinogenic events. Theoretical experimental studies state that p53-Mdm2 network constitutes core module of regulatory interactions activated by stress among a great variety signaling pathways. In this paper, strategy control regulated p14ARF is developed, based on pinning technique, which consists into applying local feedback controllers small number nodes (pinned ones) in network. Pinned are selected basis their...
SKH1 hairless mice are widely used in carcinogenesis and dermatology research due to their bare skin, as exposure different agents is facilitated. Minoxidil a cosmetic drug that recognized mitogenic agent, mitogens suggested have carcinogenic mutagenic potential by inducing cell division increasing the possibility of perpetuating DNA damage. Therefore, we hypothesized application high doses minoxidil skin would increase number micronucleated erythrocytes (MNEs) peripheral blood. The...
Air pollution has become a serious public health problem globally. Recent studies support the harmful effect of air on human health, in addition to scientific evidence that recognizes it as carcinogen. The buccal micronucleus cytome (BMC) assay is employed extensively measure cytotoxic and genotoxic damage population exposed environmental contamination. objective this study was evaluate effects healthy young adults different levels identify areas with rates above regulatory limits. This...
Introducción: La Diabetes Mellitus Gestacional (DMG) es una condición metabólica compleja que afecta la salud materna y fetal, cuál a incrementado su diagnóstico en los últimos años. Se ha asociado con anomalías cardiacas fetales (ACF), por lo fundamenteal conocer las bases moleculares de desarrollo. Objetivo: Analizar literatura científica actual, para identificar mecanismos vías clave implicados afección miocárdica fetal. Metodología: Consulta datos Pubmed, Scopus Web of Science. Las...
Single nucleotide polymorphisms in the mitochondrial genome have been investigated relation to breast cancer. Certain variants could be associated with an increased risk of this malignant disease. These associations underline importance function cancer biology and highlight potential for mtDNA-based biomarkers future therapies. The general objective research was develop a model which is capable identifying nonlinear patterns sequences. Association rules were used explore mtDNA variant...
Stroke is the third cause of death worldwide and a health problem, current therapy continues to be very poor. It promotes an alteration associated with excitotoxicity, oxidative stress, inflammatory processes, exacerbating damage in brain. Although cortical areas are most affected by stroke, hippocampus can impacted long term through pathways it connects these areas, which further motor alterations; this encourages search for new therapeutic approaches. Omega-5, being antioxidant,...
A gene regulatory network is a set of genes, and products, which regulates specific cell function. Gene networks modeling simulation prove to be powerful tool in studying regulated processes living organisms. Tumour suppressor protein p53 key control cellular functions, under stress or damage; it can activate commands for growth arrest apoptosis. controlled by negative regulators such as Mdm2 an indirect regulator (ARF). This paper applies pinning regulate the activity p53-Mdm2 feedback loop...
Type 2 diabetes (T2D) is a chronic systemic disease with complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted secondary analysis of complete mtDNA sequences from 1,261 T2D patients 1,105 control individuals. Our findings revealed significant associations between certain single nucleotide polymorphisms (SNPs) T2D. Notably, the variants m.1438A>G (controls: 32 [27.6%], T2D: 84 [72.4%]; OR:...
Gene regulatory networks are important to understand cellular processes and open a door for fighting diseases in which these play fundamental role. p53 has been named as "the guardian of the genome" Mdm2 is its principal negative regulator. The p53-Mdm2 network structurally biologically well understood known. In this paper, regulated by p300 HDAC1 modeled fourteen ordinary differential equations. Then, using such model, an oncogenic condition overexpression functional suppression simulated...
Breast cancer has an important incidence in the worldwide female population. Although alterations mitochondrial genome probably play role carcinogenesis, actual evidence is ambiguous and inconclusive. Our purpose was to explore differences sequences of cases with breast compared control samples from different origins. We identified 124 mtDNA associated cases, which 86 were complete 38 partial sequences. Of these sequences, 52 belonged patients a confirmed diagnosis cancer, 34 obtained...