A5037079808- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Cell death mechanisms and regulation
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Biomarkers in Disease Mechanisms
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Sirtuins and Resveratrol in Medicine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Intraperitoneal and Appendiceal Malignancies
- Insect Resistance and Genetics
- Phagocytosis and Immune Regulation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Advanced Proteomics Techniques and Applications
Instituto Nacional de Enfermedades Respiratorias
2021-2024
Hospital Central Militar
2023
Universidad Autónoma Metropolitana
2019-2023
Secretaría de la Defensa Nacional
2023
Ministerio de Salud Pública
2020
Universidad Nacional Autónoma de México
2004-2014
Instituto de Biomedicina de Valencia
2011
Consejo Superior de Investigaciones Científicas
2011
Centro de Investigacion Principe Felipe
2009-2011
Overproduction of inflammatory cytokines is a keystone event in COVID-19 pathogenesis; TNF and its receptors (TNFR1 TNFR2) are critical pro-inflammatory molecules. ADAM17 releases the soluble (sol) forms TNF, TNFR1, TNFR2. This study evaluated TNFRs, at protein, transcriptional, gene levels patients with different disease severity. In total, 102 were divided into mild, moderate, severe condition groups. A group healthy donors (HD; n = 25) was included. Our data showed that solTNFR1 solTNFR2...
TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can induce senescence a death process called PANoptosis. This study included 138 vaccine-naïve COVID-19 patients, who were divided into four groups (Gp) according to the plasma level of (High [
The use of chemopreventive natural compounds represents a promising strategy in the search for novel therapeutic agents cancer. Resveratrol (3,4′,5-trans-trihydroxystilbilene) is dietary polyphenol found fruits, vegetables and medicinal plants that exhibits antitumor effects. In this study, we searched modulated proteins with preventive or potential MCF-7 breast cancer cells exposed to resveratrol. Using two-dimensional electrophoresis significant changes (FC >2.0; p≤0.05) expression 16...
Abstract Background The impact of genetic variants in the expression tumor necrosis factor-α (TNF-α) and its receptors coronavirus disease 2019 (COVID-19) severity has not been previously explored. We evaluated association TNF (rs1800629 rs361525), TNFRSF1A (rs767455 rs1800693), TNFRSF1B (rs1061622 rs3397) with COVID-19 severity, assessed as invasive mechanical ventilation (IMV) requirement, plasma levels soluble TNF-α, TNFR1, TNFR2 patients severe COVID-19. Methods study included 1353...
Macrophages are necessary to eliminate pathogens. However, some pathogens have developed mechanisms avoid the immune response. One of them is modulating cell death mechanism favor pathogen survival. In this study, we evaluated if virulent Mycobacterium tuberculosis (M. tb) can simultaneously activate more than one mechanism. We infected human monocyte-derived macrophages (MDM) in vitro with avirulent (H37Ra) and (H37Rv) strains, then measured molecules involved apoptosis, necroptosis,...
Persistent respiratory symptoms and lung abnormalities post-COVID-19 are public health problems. This study evaluated biomarkers to stratify high-risk patients the development or persistence of interstitial disease.
BACKGROUND: Recent studies indicate that serum from cancer patients contains auto-antibodies against oncoproteins so called tumor-associated antigens (TAAs), which represent promising diagnostic and prognostic biomarkers. OBJECTIVES: In this study we searched for breast cancer-associated auto-antib odies individual TAAs. Also evaluated if a panel of multiple TTAs would improve the detection auto-antibodies. We screened CEA, CCBN1, c-Myc, p53, Ki-67, Nm23, PRDX6, eIF5A, PARK7, GLIO-1, Hsp27...
An array of phage-displayed mimetic peptides representing 18 sequences from the HIV-1 gp41 immunodominant epitope was fabricated on a nitrocellulose membrane. It used to compare antibody-binding affinity peptide and monitor immune response four patients prior after initiation Highly Active Anti-Retroviral Therapy in parallel assays with several probes using near-infrared fluorescence detection. The proposed multiplexed approach is highly sensitive, consumes less sample can be analyze...
<b>Background:</b> TNF and its receptors (TNFR1 TNFR2) have been implicated in the severity of COVID-19. But it has not explored association genetic variants with cytokine levels. <b>Aims:</b> We assessed <i>TNF</i> (rs1800629, rs361525), <i>TNFRSF1A</i> (rs767455, rs1800693), <i>TNFRSF1B</i> (rs1061622, rs3397) single nucleotide TNF, TNFR1, TNFR2 plasma levels patients severe <b>Methods:</b> The study included 334 COVID-19 hospitalized Mexico9s Instituto Nacional de Enfermedades...
Background Since the monoclonal antibody 2F5 (mAb 2F5) was isolated in early 90’s, its epitope have continued to be focus of extensive investigations attempting elucidate mechanism by which impedes viral entry into host cells. Because DKW-flanking amino acids are strongly conserved viruses, it is not clear whether DKW only satisfies recognition demand. Methods We used phage display technology involving biopanning a pIII-type 7-mer constrained peptide library (not screened previous...
Results Related to CSGKLIC immunodominant epitope, a library of 10E9 sequences were converted into homogeneous population in which 79% peptides contained only the CxxKxxC-motif (x represent non-epitope amino acid). The mimotopes displayed structural, antigenic and immunogenic features HIV-1 immnudominant loop epitope. In case GPGR two motifs most interesting G(P/Q)GP from linear PxxxGPG constrained library. After four immunizations with both peptide groups, anti-sera showed strong reactivity...
La presente investigacion trata sobre el caso de una paciente con un cuadro dolor abdominal agudo y gran tumoracion abdominal, llega a la Clinica Sur Hospital en base los estudios clinicos imagenes se postulo diagnostico abdomen por posible torsion tumor gigante ovario. laparotomia exploratoria demostro apendice cecal plastronada ovario derecho que histopatologicos resulto ser apendicitis aguda cistoadenoma mucinoso benigno