A5086645687- FOXO transcription factor regulation
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Bone Tumor Diagnosis and Treatments
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Teratomas and Epidermoid Cysts
- Trigeminal Neuralgia and Treatments
- History of Medical Practice
- Craniofacial Disorders and Treatments
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury Research
- Adolescent and Pediatric Healthcare
- Global Public Health Policies and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Experimental and Theoretical Physics Studies
Cincinnati Children's Hospital Medical Center
2018-2025
University of Cincinnati Medical Center
2016-2024
Wake Forest University
2024
University of Cincinnati
2017-2023
German Cancer Research Center
2023
Hopp Children's Cancer Center Heidelberg
2023
Heidelberg University
2023
Sabin Vaccine Institute
2023
Dana-Farber Cancer Institute
2023
Keck Hospital of USC
2023
Tuberculum sellae meningiomas frequently extend into the optic canals. Radical tumor resection including involved dural attachment, underlying hyperostotic bone, and intracanalicular in canal offers best chance of a Simpson Grade I to minimize recurrence. Decompression with removal also improves visual outcome since this portion is usually cause asymmetrical loss. The purely endoscopic endonasal extended transsphenoidal approach direct midline trajectory immediate access tuberculum without...
Olfactory groove meningiomas represent 10% of intracranial and arise in the midline anterior cranial fossa along dura cribriform plate planum sphenoidale. Hyperostosis adjacent underlying bone is common, further extension into ethmoid sinuses nasal cavity can occur 15%-25% cases. Radical tumor resection including involved dural attachment hyperostotic offers best chance a Simpson Grade I to minimize recurrence. Incomplete removal result recurrence at with paranasal sinuses. Resection has...
Abstract Background Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique genetic makeup, pathological heterogeneity, and brainstem location all present challenges to treatment. Developing mouse models that accurately reflect each of these distinct features will be critical advance our understanding DIPG development, progression, therapeutic resistance. The aim this study was generate new DIPG, characterize the role specific oncogenic combinations...
Abstract Background In this priority-setting exercise, we sought to identify leading research priorities needed for strengthening future pandemic preparedness and response across countries. Methods The International Society of Global Health (ISoGH) used the Child Nutrition Research Initiative (CHNRI) method preparedness. Eighty experts in global health, translational clinical identified 163 ideas, which 42 then scored based on five pre-defined criteria. We calculated intermediate...
Retrochiasmatic craniopharyngiomas are challenging tumors to remove given their deep location and proximity critical neurovascular structures. Complete surgical removal offers the best chance of cure prevention recurrence. The endoscopic endonasal extended transsphenoidal approach direct midline access retrochiasmatic space through a transplanum transtuberculum corridor. Excellent visualization undersurface optic chiasm hypothalamus can be obtained facilitate bimanual extracapsular...
Spinal cord stimulation has been shown to improve pain relief and reduce narcotic analgesic use in cases of complex refractory syndromes. However, a subset patients ultimately undergoes removal the spinal stimulator (SCS) system, presumably because surgical complications or poor efficacy. This retrospective study addresses paucity evidence regarding risk factors underlying causes failures that necessitate this explantation.
The COVID-19 pandemic has caused disruptions to the functioning of societies and their health systems. Prior pandemic, systems in low- middle-income countries (LMIC) were particularly stretched vulnerable. International Society Global Health (ISoGH) sought systematically identify priorities for research that would have potential reduce impact LMICs.The Child Nutrition Research Initiative (CHNRI) method was used COVID-19-related priorities. All ISoGH members invited participate. Seventy-nine...
Background Endoscopic endonasal transcribriform (EET) resection of anterior skull base (ASB) tumors results in large defects that may extend the entirety cribriform plate. repair these can often be challenging. We describe our reconstruction technique for ASB after EET tumors. This triple‐layer is comprised autologous fascia lata, acellular dermal allograft, and a vascularized pedicled nasoseptal flap (PNSF). The described postoperative cerebrospinal fluid (CSF) leak rate evaluated. Methods...
Developed over a century ago, the transsphenoidal approach to access lesions of pituitary gland and sella turcica has transformed field neurosurgery, largely due work Oskar Hirsch Harvey Cushing. Furthermore, its use modification in early 1900s was perhaps one Cushing's greatest legacies skull base surgery. However, Cushing, who had worked relentlessly improve route region, abandoned by 1929 his pursuit master transcranial approaches suprasellar region. few other surgeons continued perform...
BACKGROUND Caudal brainstem dysfunction associated with Chiari malformation type II (CM-II) is an important source of morbidity and mortality in neonates myelomeningocele (MMC). OBSERVATIONS Prenatal MMC repair has been shown to improve or even completely reverse the extent hindbrain herniation (HH) CM-II as well reduce incidence hydrocephalus requiring CSF diversion, possibly leading a reduction CM-II–related symptoms these children. Urgent diversion potential decompression surgery are...
Spina bifida is the most common nonchromosomal birth defect, resulting in permanent disability of multiple organ systems, yet compatible with long-term survival. Important advances across various disciplines have now improved survival among spina population. Although majority individuals living are adults, there few publications neurosurgical literature regarding care adults bifida, associated medical conditions, surgical interventions, and complications. The major goals for transitioning...
Abstract With its inception nearly half a century ago through the pioneering work of Dandy, McLean, and Smith, anterior skull base (ASB) surgery is relatively young discipline. It became distinct entity in 1963 when Ketcham popularized combined transcranial transfacial approach for en bloc resection tumors paranasal sinuses extending into cranial fossa. However, because these procedures resulted major morbidities mortalities, alternative modes treatment were sought. Since 1970s, introduction...
Abstract Forkhead box R2 (FOXR2) is a forkhead transcription factor located on the X chromosome whose expression normally restricted to testis. In this study, we performed pan-cancer analysis of FOXR2 activation across more than 10,000 adult and pediatric cancer samples found be aberrantly upregulated in 70% all types 8% individual tumors. The majority tumors (78%) expressed through previously undescribed epigenetic mechanism that involves hypomethylation novel promoter, which was...
Percutaneous stereotactic radiofrequency rhizotomy (PSR) is often used to treat trigeminal neuralgia, a serious condition that results in lancinating, episodic facial pain. Thorough understanding of the microsurgical anatomy foramen ovale (FO) and its surrounding structures required for efficient, effective, safe use this technique. This morphometric study compares anatomical surgical orientations identify variations FO assess cannulation difficulty.
Max Brödel is considered the father of modern medical illustration. This report reviews his contributions to neurosurgery as a illustrator. Brödel, young artist from Leipzig, Germany, was hired at Johns Hopkins Hospital in 1894, where he illustrated an operative textbook gynecology for Howard A. Kelly. Although did not have any formal training, quickly acquired knowledge anatomy, pathology, physiology, and surgery. Brödel's extraordinary illustrations were characterized by aerial perspective...
The middle cranial fossa (MCF) approach is a challenging surgical technique for the resection of small and intermediate sized, primarily intracanalicular, vestibular schwannomas (VS), with goal hearing preservation (HP).To describe decade-long, single institutional experience MCF VS.This retrospective cohort study 63 patients who underwent VS from 2006 to 2016. Audiometric data included pure-tone average (PTA), low-tone (LtPTA), word recognition score, American Academy Otolaryngology-Head...