A5045058096- Amyotrophic Lateral Sclerosis Research
- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Coenzyme Q10 studies and effects
- Hereditary Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Multiple Sclerosis Research Studies
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Spine and Intervertebral Disc Pathology
- Mast cells and histamine
- Fibromyalgia and Chronic Fatigue Syndrome Research
Hospital for Sick Children
2022-2023
University of Toronto
2022-2023
Great Ormond Street Hospital
2022
University College London
2022
SickKids Foundation
2022
Montreal Neurological Institute and Hospital
2019-2021
McGill University
2019-2021
York University
2017
University of Michigan
2015
Alzheimer's disease (AD) and Parkinson's (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial understand how the Aβ/αSYN aggregates can be cleared. Compelling data indicate that neuroinflammatory cells, including astrocytes microglia, play a central role in pathogenesis AD PD. However, interplay between two cell types affects their clearing capacity consequently progression...
Antibodies are a key resource in biomedical research yet there no community-accepted standards to rigorously characterize their quality. Here we develop procedure validate pre-existing antibodies. Human cell lines with high expression of target, determined through proteomics database, modified CRISPR/Cas9 knockout (KO) the corresponding gene. Commercial antibodies against target purchased and tested by immunoblot comparing parental KO. Validated used definitively identify most highly...
Chronic pain is a devastating problem affecting one in five individuals around the globe, with neuropathic most debilitating and poorly treated type of chronic pain. Advances transcriptomics have contributed to cataloguing diverse cellular pathways transcriptomic alterations response peripheral nerve injury but focused on phenomenology classifying responses.To identifying new types pain-relieving agents, we compared transcriptional reprogramming changes dorsal spinal cord after cross-sex...
Background and Purpose: Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic most debilitating poorly treated type of chronic pain. Advances transcriptomics data mining have contributed to cataloging diverse cellular pathways transcriptomic alterations response peripheral nerve injury but focused on phenomenology classifying responses. Experimental approach: Here, goal identifying new types pain-relieving agents, we compared transcriptional...
Abstract Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic most debilitating and poorly treated type of chronic pain. Advances transcriptomics data mining have contributed to cataloging diverse cellular pathways transcriptomic alterations response peripheral nerve injury but focused on phenomenology classifying responses. Here, goal identifying new types pain-relieving agents, we compared transcriptional reprogramming changes dorsal spinal...
Background Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, increases inflammation apoptosis the quadriceps of females. ALS, a neuromuscular disease, causes progressive degeneration neurons brain spinal cord. Objective We analyzed cords mice following dietary at 2.5% adequate intake (AI) for oxidative damage (4-HNE, 3-NY), antioxidant enzymes (SOD2, catalase, GPx1), (TNF-α, IL-6, IL-10), (bax/bcl-2 ratio, CASP3 cleaved/pro ratio),...