A5082668104- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Chemical Reactions and Isotopes
- Cyclopropane Reaction Mechanisms
- Chemical Reaction Mechanisms
- DNA and Nucleic Acid Chemistry
- Phytochemistry and Biological Activities
- Radical Photochemical Reactions
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Structural Characterization
- Plant and Fungal Species Descriptions
- Neuroscience and Neuropharmacology Research
- Natural product bioactivities and synthesis
- Medicinal plant effects and applications
- Catalytic Alkyne Reactions
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
University of Pavia
2021-2024
Scripps (United States)
2022-2024
Scripps Institution of Oceanography
2022-2024
Torrey Pines Institute For Molecular Studies
2022-2024
Takeda (United States)
2024
Scripps Research Institute
2021-2023
The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification lead compounds truncating retrosynthetic plans, there a growing need for new reagents methods achieving such transformation both academic industrial circles. One main drawback current chemical the lack diversity with regard structure reactivity that prevents combinatorial approach rapid screening be employed. In regard,...
A concise, modular synthesis of the novel antibiotic darobactin is disclosed. The successfully forges hallmark strained macrocyclic ring systems in a sequential fashion. Key transformations include two atroposelective Larock-based macrocyclizations, one which proceeds with exquisite regioselectivity despite bearing an unprotected alkyne. designed medicinal chemistry considerations mind, appending key portions molecule at late stage. Requisite unnatural amino acid building blocks are easily...
The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This enlists a singular aziridine ring opening strategy to access two disparate β-aryl-branched amino acids present within this complex decapeptide. Featuring number unique maneuvers navigate inherently sensitive and epimerizable functional groups, convergent approach proceeds in only 16 steps (LLS) from commercial materials should facilitate numerous analogues for medicinal chemistry studies.
Chlorine is one of the most common atoms present in small-molecule drugs beyond carbon, hydrogen, nitrogen and oxygen. There are currently more than 250 FDA-approved chlorine-containing drugs, yet beneficial effect chloro substituent has not been reviewed. The simple substitution a hydrogen atom (R = H) with chlorine Cl) can result incredible improvements potency up to 100,000-fold, lead profound effects on pharmacokinetic parameters such as clearance, half-life, drug exposure vivo....
A concise, modular synthesis of the novel antibiotic darobactin is disclosed. The successfully forges hallmark strained macrocyclic ring systems in a sequential fashion. Key transformations include two atroposelective Larock-macrocylizations, one which proceeds with exquisite regioselectivity despite bearing an unprotected alkyne. designed medicinal chemistry considerations mind, appending key portions molecule at late-stage. Requisite unnatural amino acid building blocks are easily prepared...
The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This capitalizes on hidden symmetry present in this complex decapeptide by enlisting an aziridine ring opening strategy to access b-branched amino acids. Featuring a number unique maneuvers navigate inherently sensitive and epimerizable functional groups, convergent approach proceeds only 14 steps (LLS) from commercial materials should facilitate numerous analogs for medicinal chemistry studies.
A novel approach for the formation of anomeric carbon-functionalized furanoside systems was accomplished through employment an oxo-rhenium catalyst. The transformation boasts a broad range nucleophiles including allylsilanes, enol ethers, and aromatics in addition to sulfur, nitrogen, hydride donors, able react with oxocarbenium ion intermediate derived from furanosidic structures. excellent stereoselectivities observed followed Woerpel model, ultimately providing 1,3-cis-1,4-trans systems....
The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organicsynthesis. From simplifying access to metabolites and late-stage diversification lead compoundsto truncating retrosynthetic plans, there a growing need for new reagents methods forachieving such transformation both academic industrial circles. One main drawback ofcurrent chemical the lack diversity with regards structure reactivity thatprevent combinatorial approach rapid screening be employed. In that...
<p>The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organic</p><p>synthesis. From simplifying access to metabolites and late-stage diversification lead compounds</p><p>to truncating retrosynthetic plans, there a growing need for new reagents methods for</p><p>achieving such transformation both academic industrial circles. One main drawback of</p><p>current chemical the lack diversity with regards structure...