A5029145907- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- CO2 Reduction Techniques and Catalysts
- Electrochemical Analysis and Applications
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ionic liquids properties and applications
- Carbon dioxide utilization in catalysis
- Arsenic contamination and mitigation
- Electrochemical sensors and biosensors
- Catalysts for Methane Reforming
- Synthesis and Catalytic Reactions
- Catalysis and Hydrodesulfurization Studies
- Advanced oxidation water treatment
- Fluorine in Organic Chemistry
- Advanced Battery Materials and Technologies
- Chemical Reactions and Isotopes
- Iron oxide chemistry and applications
- Eicosanoids and Hypertension Pharmacology
- Zeolite Catalysis and Synthesis
- Advancements in Battery Materials
- Inorganic Fluorides and Related Compounds
- Electrocatalysts for Energy Conversion
University of Minnesota
2021-2025
University of Minnesota System
2021-2024
Indian Institute of Technology Delhi
2017-2019
The "magic methyl" effect, a dramatic boost in the potency of biologically active compounds from incorporation single methyl group, provides simple yet powerful strategy employed by medicinal chemists drug discovery process. Despite significant advances, methodologies that enable selective C(sp3)–H methylation structurally complex agents remain very limited. In this work, we disclose modular, efficient, and for α-methylation protected amines (i.e., amides, carbamates, sulfonamides) means...
The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification lead compounds truncating retrosynthetic plans, there a growing need for new reagents methods achieving such transformation both academic industrial circles. One main drawback current chemical the lack diversity with regard structure reactivity that prevents combinatorial approach rapid screening be employed. In regard,...
Alcohol oxidation is an important class of reaction that traditionally performed under harsh conditions and most often requires the use organometallic compounds or transition metal complexes as catalysts. Here, we introduce a new electrochemical synthetic method, referred to reductive oxidation, in which alcohol initiated by redox-mediated electrocatalytic reduction peroxydisulfate generate highly oxidizing sulfate radical anion. Thus, counter-intuitively, occurs result reaction. This...
This report describes the design, development, and optimization of an electrochemical deoxyfluorination arenes using a tetrafluoropyridine-derived leaving group. NEt3·3HF serves as fluoride source, reactions are conducted either constant potential or current electrolysis in undivided cell. Mechanistic studies support net oxidative pathway, which initial single-electron oxidation generates radical cation intermediate that is trapped by fluoride. The resulting undergoes second reaction,...
In the present study, stable sodium plating/stripping has been achieved on a bare aluminum current collector, without any surface modifications or artificial SEI deposition. The crucial role of predeposited using cyclic voltammetry as matrix for highlighted different protocols cycling. predeposition strategy ensures and efficient cycling in anode-free batteries dendritic formations. study highlights difference carbonate glyme solvent electrolytes collector. Contrary to electrolyte, cell with...
Aqueous solutions containing both the strong oxidant, peroxydisulfate (S2O82‒), and reductant, oxalate (C2O42‒), are thermodynamically unstable due to highly exothermic homogeneous redox reaction: S2O82‒ + C2O42‒ ® 2 SO42‒ CO2 (DG0 = −490 kJ/mol). However, at room temperature, this reaction does not occur a significant extent over timescale of day its inherently slow kinetics. We demonstrate that S2O82‒/C2O42‒ occurs rapidly, once initiated by Ru(NH3)62+-mediated 1e– reduction form S2O83•‒...
Aqueous solutions containing both the strong oxidant, peroxydisulfate (S2O82‒), and reductant, oxalate (C2O42‒), are thermodynamically unstable due to highly exothermic homogeneous redox reaction: S2O82‒ + C2O42‒ ® 2 SO42‒ CO2 (DG0 = −490 kJ/mol). However, at room temperature, this reaction does not occur a significant extent over timescale of day its inherently slow kinetics. We demonstrate that S2O82‒/C2O42‒ occurs rapidly, once initiated by Ru(NH3)62+-mediated 1e– reduction form S2O83•‒...
Carbon−halogen bond cleavage has been studied extensively for many years as a simple electrosynthesis step in the formation of more complex natural products. Reduction halogenated phenols received less attention, part, due to lowered faradaic efficiency resulting from competing hydrogen evolution reaction. Herein, we report electroreduction series brominated through homogeneous electrocatalytic (EC′) mechanism. Beginning with structurally 2-bromophenol, use foot-of-the-wave analysis...
Aqueous solutions containing both the strong oxidant, peroxydisulfate (S
Selective C-H bond activation is one of the most critical molecular transformations in synthesizing chemicals, pharmaceuticals, and natural product intermediates with broad applications. Recent efforts have focused on developing electrocatalytic mediators that rapidly selectively activate specific bonds. These mediated activations offer multiple benefits over direct electrochemical oxidation as they can occur at lower overpotentials, leading to higher faradaic efficiency selectivity reduced...
The “magic methyl” effect – a dramatic boost in the potency of biologically active compounds from incorporation single methyl group provides simple yet powerful strategy employed by medicinal chemists drug discovery process. Despite significant advances, methodologies that enable selective C(sp3)–H methylation structurally complex agents remain very limited. In this work, we disclose modular, efficient, and for α-methylation protected amines (i.e., amides, carbamates, sulfonamides) means...
The “magic methyl” effect – a dramatic boost in the potency of biologically active compounds from incorporation single methyl group provides simple yet powerful strategy employed by medicinal chemists drug discovery process. Despite significant advances, methodologies that enable selective C(sp3)–H methylation structurally complex agents remain very limited. In this work, we disclose modular, efficient, and for α-methylation protected amines (i.e., amides, carbamates, sulfonamides) means...
The “magic methyl” effect – a dramatic boost in the potency of biologically active compounds from incorporation single methyl group provides simple yet powerful strategy employed by medicinal chemists drug discovery process. Despite significant advances, methodologies that enable selective C(sp3)–H methylation structurally complex agents remain very limited. In this work, we disclose modular, efficient, and for α-methylation protected amines (i.e., amides, carbamates, sulfonamides) means...
Layered black arsenic (b-As) has recently emerged as a new anisotropic two-dimensional (2D) semiconducting material with applications in electronic devices. Understanding factors affecting the ambient stability of this remains crucial for its applications. Herein, we use first-principles density functional theory calculations to examine (010) and (101) surfaces b-As presence O2 H2O. We show that surface can easily oxidize O2. In moisture contained air, oxidized favorably react H2O molecules...
The direct, transition metal-catalyzed carboxylation of organohalides with carbon dioxide is a highly desirable transformation in organic synthesis as it utilizes feedstock chemicals and delivers carboxylic acids –among the most utilized class molecules. Phenyl acetic acids, particular, are privileged motifs that appear many pharmaceuticals biologically active compounds. This article reports development sustainable selective cobalt-catalyzed electrochemical benzyl halides CO2 to generate...
Layered black arsenic (b-As) has recently emerged as a new anisotropic two-dimensional (2D) semiconducting material with applications in electronic devices. Understanding factors affecting the ambient stability of this remains crucial for its applications. Herein we use first-principles density functional theory (DFT) calculations to examine (010) and (101) surfaces b-As presence oxygen (O2) water (H2O). We show that surface can easily oxidize O2. In moisture contained air, oxidized...
The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organicsynthesis. From simplifying access to metabolites and late-stage diversification lead compoundsto truncating retrosynthetic plans, there a growing need for new reagents methods forachieving such transformation both academic industrial circles. One main drawback ofcurrent chemical the lack diversity with regards structure reactivity thatprevent combinatorial approach rapid screening be employed. In that...
The direct, transition metal-catalyzed carboxylation of organohalides with carbon dioxide is a highly desirable transformation in organic synthesis as it utilizes feedstock chemicals and delivers carboxylic acids –among the most utilized class molecules. Phenyl acetic acids, particular, are privileged motifs that appear many pharmaceuticals biologically active compounds. This article reports development sustainable selective cobalt-catalyzed electrochemical benzyl halides CO2 to generate...
The “magic methyl” effect – a dramatic boost in the potency of biologically active compounds from incorporation single methyl group provides simple yet powerful strategy employed by medicinal chemists drug discovery process. Despite significant advances, methodologies that enable selective C(sp3)–H methylation structurally complex agents remain very limited. In this work, we disclose modular, efficient, and for α-methylation protected amines (i.e., amides, carbamates, sulfonamides) means...
<p>The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organic</p><p>synthesis. From simplifying access to metabolites and late-stage diversification lead compounds</p><p>to truncating retrosynthetic plans, there a growing need for new reagents methods for</p><p>achieving such transformation both academic industrial circles. One main drawback of</p><p>current chemical the lack diversity with regards structure...