A5082072514- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Catalytic C–H Functionalization Methods
- Advanced Battery Technologies Research
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Reactions
- Extraction and Separation Processes
- Radical Photochemical Reactions
- Chemical synthesis and alkaloids
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Carbohydrate Chemistry and Synthesis
- Alkaloids: synthesis and pharmacology
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Microbial Metabolic Engineering and Bioproduction
Bristol-Myers Squibb (United States)
2015-2024
The Bristol-Myers Squibb Children's Hospital
2020-2024
Fraunhofer Institute for Material Flow and Logistics
2022
Bristol-Myers Squibb (Germany)
2011-2021
Genomic Health (United States)
2021
BASF (Germany)
2012-2018
Scripps Research Institute
2016-2018
BASF (United States)
2014-2015
Merck (Germany)
2000-2013
Universität Hamburg
2005-2012
We report herein on the comparative study of and electrodes in three salt solutions, namely, , a mixture commonly used ethylene dimethyl carbonates. The surface chemistry these solutions was studied by surface‐sensitive Fourier transform infrared spectroscopy. X‐ray photoelectron spectroscopy, energy‐dispersive analysis, their electrochemical behavior variable‐scan‐rate voltammetry impedance It found that is strongly dependent chemistry. Complicated reactions between active mass solution...
Abstract One of the major hurdles Ni‐rich cathode materials Li 1+ x (Ni Co z Mn ) w O 2 , y > 0.5 for lithium‐ion batteries is their low cycling stability especially compositions with Ni ≥ 60%, which suffer from severe capacity fading and impedance increase during at elevated temperatures (e.g., 45 °C). Two promising surface structural modifications these to alleviate above drawback are (1) coatings by electrochemically inert inorganic compounds ZrO or (2) lattice doping cations like Zr...
Stitching C-N bonds from nitro groups Numerous compounds in pharmaceutical research have carbon-nitrogen bonds, and chemists are always looking for ways to make them more efficiently. Gui et al. present a method that links the carbon an olefin nitrogen nitroaromatic compound (see Perspective by Kürti). Nitroaromatics readily available, tolerates wide range of other chemical on either reacting partner. Science , this issue p. 886 ; see also 863
A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use redox-active esters allow one employ such derivatives as halides surrogates. chemistry exhibits broad substrate scope and features a high degree practicality. procedure extremely inexpensive nature both substrates pre-catalyst (NiCl2·6H2O, ca. $9.5/mol) bode well for immediate widespread adoption method.
We report the highly stable galvanostatic cycling of lithium metal (Li) electrodes in a symmetrical Li|electrolyte solution|Li coin-cell configuration at high rate and areal capacity using fluoroethylene carbonate (FEC)-based electrolyte solutions [1 M LiPF6 FEC/dimethyl (DMC)]. The FEC-based solution shows behavior that is markedly better than observed for cells cycled with an ethylene (EC)-based (1 EC/DMC). With solution, Li|Li can be 2 mA cm–2 3.3 mAh more 1100 cycles, full...
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation this chiral motif has long been hampered by the systemic use phosphorus(III) [P(III)]-based reagent systems sole practical means assembly. A fundamentally different approach is described herein: invention a...
Over the past decade, chemists have embraced visible-light photoredox catalysis due to its remarkable ability activate small molecules. Broadly, these methods employ metal complexes or organic dyes convert visible light into chemical energy. Unfortunately, excitation of widely utilized Ru and Ir chromophores is energetically wasteful as ∼25% energy lost thermally before being quenched productively. Hence, methodologies require high-energy, intense accommodate said catalytic inefficiency....
Abstract We disclose the development of a Cu‐catalyzed C−O coupling method utilizing new N 1 , 2 ‐diarylbenzene‐1,2‐diamine ligand, L8 . Under optimized reaction conditions, structurally diverse aryl and heteroaryl bromides underwent efficient with variety alcohols at room temperature using an ‐based catalyst. Notably, ‐derived catalyst exhibited enhanced activity when compared to L4 system previously disclosed for C−N coupling, namely ability functionalize containing acidic functional...
[reaction: see text] A catalytic amidation of unactivated esters with amino alcohols is described. series solution studies in addition to the first X-ray structure a carbene-alcohol complex support carbene-base nucleophile activation mechanism.
Conjoined twins: An efficient and convergent strategy for the synthesis of dimeric hexahydropyrroloindole alkaloids, (+)-chimonanthine, (+)-folicanthine, (−)-calycanthine, is described. The simultaneous formation vicinal quaternary stereocenters by using a reductive dimerization reaction provides an access to optically active key intermediate on gram scale. Supporting information this article available WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700705_s.pdf or from author....
The effect of fluorinated ethylene carbonate (FEC) as a cosolvent in alkyl carbonates/LiPF6 on the cycling performance high-voltage (5 V) cathodes for Li-ion batteries was investigated using electrochemical tools, X-ray photoelectron spectroscopy (XPS), and high-resolution scanning electron microscopy (HRSEM). An excellent stability LiCoPO4/Li, LiNi0.5Mn1.5O4/Si, LiCoPO4/Si cells reasonable achieved by replacing commonly used (EC) FEC electrolyte solutions batteries. roles improvement...
On a fast track: The secondary metabolites (+)-WIN 64821 and (−)-ditryptophenaline have been synthesized in six seven steps, respectively, from amino acid derivatives concise enantioselective manner. gram-scale synthesis of key intermediates the simultaneous introduction vicinal quaternary stereocenters are described. structural confirmation (−)-1′-(2-phenylethylene)ditryptophenaline is also reported. Supporting information for this article available on WWW under...
Kinetic, spectroscopic, crystallographic, and computational studies probing a Pd-catalyzed C-H arylation reaction reveal that mono-oxidation of the bis-phosphine ligand is critical for formation active catalyst. The mono-oxide shown to be hemilabile, bidentate palladium. Isolation oxidative addition adduct, with structural elucidation by X-ray analysis, showed was catalytically competent, giving same rate in productive as Pd(II)/xantphos precursor. A dual role carboxylate base both catalyst...
The effect of the electrolyte solution composition and cycling protocol on long-term performance surface chemistry monolithic amorphous columnar silicon film electrodes was investigated using electrochemical tools, XPS, SEM EDS. An excellent stability Si in fluoroethylene carbonate (FEC)-based solutions demonstrated. It relates to ability FEC form polyenes, as well a high rate HF formation its water contaminated LiPF6 solutions, measured by 19F NMR spectroscopy. We found that passivation...
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on P(V) oxidation state. redox-economical approach can be used to append nearly any kind cargo onto serine, generating stable, benign, hydrophilic phosphorothioate linkage. The tolerates all other known nucleophilic functional groups naturally occurring proteinogenic amino acids. A variety applications...
Phosphorus Incorporation (PI, abbreviated Π) reagents for the modular, scalable, and stereospecific synthesis of chiral phosphines methylphosphonate nucleotides are reported. Synthesized from trans-limonene oxide, this reagent class displays an unexpected reactivity profile enables access to chemical space distinct that Phosphorus-Sulfur previously disclosed. Here, adaptable phosphorus(V) scaffold sequential addition carbon nucleophiles produce a variety enantiopure C-P building blocks....
The site-specific oxidation of strong C(sp3)-H bonds is uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification lead compounds truncating retrosynthetic plans, there a growing need for new reagents methods achieving such transformation both academic industrial circles. One main drawback current chemical the lack diversity with regard structure reactivity that prevents combinatorial approach rapid screening be employed. In regard,...
The promise of gene-based therapies is being realized at an accelerated pace, with more than 155 active clinical trials and multiple U.S. Food Drug Administration approvals for therapeutic oligonucleotides, by far most which contain modified phosphate linkages. These unnatural linkages have desirable biological physical properties but are often accessed difficulty using phosphoramidite chemistry. We report a flexible efficient [P(V)]–based platform that can install wide variety will into...