A5006012030- CO2 Reduction Techniques and Catalysts
- RNA and protein synthesis mechanisms
- Carbon dioxide utilization in catalysis
- Bacterial Genetics and Biotechnology
- Ionic liquids properties and applications
- CRISPR and Genetic Engineering
- Microbial Fuel Cells and Bioremediation
- Electrochemical sensors and biosensors
University of Washington
2023-2024
University of Utah
2021-2023
One of the central roles in design, development, and application advances mediator-based microbial electrochemical systems, such as fuel cells (MFCs), is establishment efficient successful communication between conductive electrode surfaces microorganisms via modes extracellular electron transfer (EET). Most microbial-based systems require use artificial electroactive mediators order to facilitate and/or enhance transfer. Our previous work established an exogenous phenazine-based library a...
Engineering metabolism to efficiently produce chemicals from multi-step pathways requires optimizing multi-gene expression programs achieve enzyme balance. CRISPR-Cas transcriptional control systems are emerging as important tools for programming expression, but poor predictability of guide RNA folding can disrupt control. Here, we correlate efficacy modified RNAs (scRNAs) CRISPR activation (CRISPRa) in E. coli with a computational kinetic parameter describing scRNA rate into the active...
ABSTRACT Engineering bacterial metabolism to efficiently produce chemicals and materials from multi-step pathways requires optimizing multi-gene expression programs achieve enzyme balance. CRISPR-Cas transcriptional control systems are emerging as important metabolic engineering tools for programming regulation. However, poor predictability of guide RNA folding can disrupt balance through unreliable control. We devised a set computational parameters that describe folding, we expect them be...
The direct, transition metal-catalyzed carboxylation of organohalides with carbon dioxide is a highly desirable transformation in organic synthesis as it utilizes feedstock chemicals and delivers carboxylic acids –among the most utilized class molecules. Phenyl acetic acids, particular, are privileged motifs that appear many pharmaceuticals biologically active compounds. This article reports development sustainable selective cobalt-catalyzed electrochemical benzyl halides CO2 to generate...
The direct, transition metal-catalyzed carboxylation of organohalides with carbon dioxide is a highly desirable transformation in organic synthesis as it utilizes feedstock chemicals and delivers carboxylic acids –among the most utilized class molecules. Phenyl acetic acids, particular, are privileged motifs that appear many pharmaceuticals biologically active compounds. This article reports development sustainable selective cobalt-catalyzed electrochemical benzyl halides CO2 to generate...