A5036728631- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Spinal Cord Injury Research
- Cancer Research and Treatments
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Immune cells in cancer
- Chemokine receptors and signaling
- Neurogenetic and Muscular Disorders Research
- interferon and immune responses
- Bone and Joint Diseases
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Epilepsy research and treatment
- Cytomegalovirus and herpesvirus research
- Molecular Biology Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
University of Liège
2014-2025
Luxembourg Institute of Health
2017-2020
Patient-based cancer models are essential tools for studying tumor biology and the assessment of drug responses in a translational context. We report establishment large cohort unique organoids patient-derived orthotopic xenografts (PDOX) various glioma subtypes, including gliomas with mutations IDH1, paired longitudinal PDOX from primary recurrent tumors same patient. show that PDOXs enable long-term propagation patient represent clinically relevant avatars retain histopathological,...
Abstract Introduction Stem cells from adult tissues were considered for a long time as promising tools regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Indeed, mesenchymal (MSCs) and neural crest stem (NCSCs) together constitute the bone marrow stromal (BMSCs) that used therapeutic options in various models experimental SCI. However, clinical approaches remained disappointing, we thought reducing BMSC heterogeneity should be potential way to improve...
Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic protein targeted by the antiseizure drug levetiracetam. One or more of three SV2 genes expressed in all neurons and essential to normal neurotransmission. Loss SV2A results seizure phenotype mice mutations humans are also linked congential seizures. How affecting action impacts epileptic remains unclear, especially among diverse neuronal populations that regulate network excitability. This study explored how brain structure function...
The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind blood barrier reducing efficacy systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes identify AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as crucial driver GBM invasion. Using patient-derived cellular models, show that loss ZFAND3 hampers invasive capacity GBM,...
Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described rodent, sources NCSC. However, very little information is available concerning their correspondence human tissues, more precisely marrow. The main objective this study was therefore to characterize NCSC from adult In purpose, we compared stromal tissue dermis,...
Bone marrow stromal cells are adult multipotent that represent an attractive tool in cellular therapy strategies. Several studies have reported vitro passaging of mesenchymal stem alters the functional and biological properties those cells, leading to accumulation genetic aberrations. Recent described bone (BMSC) as mixed populations including (MSC) neural crest (NCSC). Here, we report transformation NCSC into tumorigenic after long-term passaging. Indeed, characterization 6 crest-derived...
Adult bone marrow stroma contains multipotent stem cells (BMSC) that are a mixed population of mesenchymal and neural-crest derived cells. Both endowed with in vitro multi-lineage differentiation abilities, then constituting an attractive easy-available source material for cell therapy neurological disorders. Whereas the vivo integration BMSC neurons into central nervous system is currently matter debate, we report here once injected striatum 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Parvalbumin-positive neurons are inhibitory that release GABA and mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly any event in the brain under normal pathological conditions. In this review, we will summarize current knowledge about fundamentals of parvalbumin-positive neurons, focusing on morphology specific channel/protein content. Next, explore development, maturation,...
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, which remains difficult to cure. The very high recurrence rate has been partly attributed presence of GBM stem-like cells (GSCs) within tumors, have associated with elevated chemokine receptor 4 (CXCR4) expression. CXCR4 frequently overexpressed cancer tissues, including GBM, and usually correlates a poor prognosis. We created CXCR4-retargeted oncolytic herpesvirus (oHSV) by insertion an anti-human nanobody glycoprotein...
SV2A is a glycoprotein present in the membranes of most synaptic vesicles. Although it has been highly conserved throughout evolution, its physiological role remains largely unknown. Nevertheless, Levetiracetam, very effective anti-epileptic drug, recently demonstrated to bind SV2A. At present, our understanding normal function and possible involvement diseases like epilepsy limited. With this study, we sought develop relevant model enabling analysis SV2A's occurrence or progression...
Abstract Background Glioblastoma (GBM), is the most fatal form of brain cancer, with a high tendency for recurrence despite combined treatments including surgery, radiotherapy, and chemotherapy temozolomide. The C-X-C chemokine receptor 4 (CXCR4) plays an important role in tumour radioresistance recurrence, considered as interesting GBM target. TRT holds untapped potential treatment, CXCR4-TRT being promising strategy recurrent treatment. Our study focuses on preclinical assessment different...
Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing treatments. Therapeutic failure both adult pHGG has been partially imputed to glioma stem cells (GSC), subset of cancer endowed stem-like cell potential malignant, invasive, adaptative, treatment-resistant capabilities. Whereas GSC have largely portrayed tumors, less information provided pHGG. The aim our study was comprehensively document the...