A5011031132- Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Alcoholism and Thiamine Deficiency
- Cardiac, Anesthesia and Surgical Outcomes
- Folate and B Vitamins Research
- Sleep and related disorders
- Acute Ischemic Stroke Management
- Hip and Femur Fractures
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Health, Environment, Cognitive Aging
- Circadian rhythm and melatonin
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Bone health and osteoporosis research
- Human Health and Disease
- Pain Management and Treatment
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
Pirogov Russian National Research Medical University
2020-2024
Helsinki University Hospital
2023
Sechenov University
2010-2012
Dementia is one of the main challenges to modern society. According estimated data, as 2019, there were 1.949.811 people living In Russia with dementia various etiology. At same time, have been no large epidemiological studies in Russian Federation. The article provides an overview available data on epidemiology cognitive impairment (CI) given from sources. Not only estimated, but also clinical analyzed. general, obtained prevalence values for CI are comparable global values. Thus, study...
Clinical guidelines «Cognitive disorders in the elderly and senile persons».
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Perioperative management of elderly patients remains one the most difficult tasks modern anesthesiology. Compared with younger patients, people over 60 years age have a higher risk developing adverse postoperative outcomes, as result age-related decline in physiological functions, presence several concomitant diseases, polypragmasia, cognitive dysfunction and specific geriatric syndromes, such frailty. More than 25 % this category chronic diseases cardiovascular, nervous, endocrine,...
Brain aging is part of the whole body, largely determining success general and quality life an older person. a complex multifactorial process that occurs throughout human’s life, which includes changes at subcellular, tissue, organ levels as well physiological level, mediating in neurophysiological (cognitive) functions. The review provides up-to-date data on morphological observed during natural aging; various phenotypes brain are discussed, including both pathologically accelerated...
The authors give the data available in literature on and results of their studies epidemiology, risk factors, pathogenesis, diagnosis, treatment poststroke cognitive impairment (PSCI). latter occurs 35—83% patients; does 6—40%. Different mechanisms PSCI are under discussion; these a single infarct strategic area brain; multiple focal lesion brain substance restrokes; cerebral white-matter as leukoaraiosis; presence concomitant Alzheimer’s disease (AD). capacities for diagnosis AD analyzed....
Vitamin B12 (cobalamin) deficiency is a common condition in the elderly. Contrary to established point of view, absence hematological changes (macrocytic anemia) does not always necessarily exclude this condition. Damage nervous system with development complex neurological and mental disorders observed even at borderline levels vitamin blood. It known, that important risk factor dementia. Cobalamin can directly lead cognitive damage or accelerate dementia due other brain pathology -...
Delirium is an acute, life-threatening condition manifested by disturbance in consciousness, attention and cognition, which has a multifactorial genesis, severe consequences commonly seen older senile people inpatient. Clinical experience domestic practice shows that delirium diagnosis patients often missed, its signs may be considered as manifestations of other diseases, while the state perceived only alcohol withdrawal. The article presents clinical protocol developed based on firsthand...
Background. Cognitive impairment (CI) is one of the important disability factors in elderly. The role CI prognosis frailest patients with limited mobility uncertain. aim. To determine influence initial cognitive status group patronage aged 60 years and older on risk mortality within year. Materials methods. Study consisted 450 from one-year period observation (from July 2019 till 2020). Initial physical, functional, neuropsychiatriac social statuses were evaluated by comprehensive geriatric...
The population of older and oldest-old individuals is increasing at a rapid pace, leading to notable proportion this age group requiring surgical procedures due multimorbidity. It known that, compared with young people, patients over 60 have whole set factors, such as decreased physiological functions, the presence several concomitant diseases, polypharmacy, cognitive dysfunction specific geriatric syndromes, which may lead higher risk postoperative complications prolonged recovery....
One of the common problems associated with aging is vitamin B12 (cobalamin) deficiency. According to some reports, it present in every third person over age 60. Cobalamin involved numerous biologically important reactions, and its deficiency manifests itself a range disorders, including hematological gastrointestinal symptoms, as well pathology various parts nervous system. The article discusses clinical variants neurological disorders related deficiency, such damage both peripheral central...
Sleep, being a fundamental requirement for the body’s well-being, plays crucial role in various essential biological processes. Aging is one of natural processes that affects all functions human body. The relationship between sleep and aging has been subject significant interest researchers recent years. article discusses modern views on its geroprotective potential. provides data study effect disorders hallmarks aging. influence deprivation, insomnia obstructive apnea syndrome nine...
The stroke is linked to the high risk of subsequent cognitive impairment. At same time results longitudinal studies suggest that in many patients main factor post-stroke impairment neurodegenerative changes, typical for Alzheimer's disease. Relationship vascular and components dementia very complex diagnostic co-occurring disease survivors associated with severe difficulties. Differentiation pure mixed after may be critical due additive synergistic effects poorer prognosis possible...
To evaluate the efficacy, safety, and compliance to therapy with Mioreol, first used as part of routine clinical practice in patients moderate-to-severe dementia due AD.The study was conducted a non-interventional observational program. The work performed on group 48 AD aged from 60 90 years (median age 74 [69; 77]). therapeutic dose Mioreol 10 mg donepezil + 20 memantine, drug taken orally, once day at same time, regardless meals. duration course 24 weeks. effects were assessed using MMSE,...
The review gives data on the epidemiology, terminology, diagnostic criteria, and standards for examination treatment of patients with vascular cognitive disorders dementia (VD). heterogeneity disorders, concurrence neurodegenerative diseases are discussed. Data from studies specific therapy VD given.
Osteoporosis and various cognitive disorders occupy a special place among number of specific pathological conditions associated with age. Epidemiologically these two are closely related thus the presence impairment increases risk osteoporosis; and, visa versa, dementia, in particular, caused by Alzheimer's disease, is more often detected patients osteoporosis. dementia an extremely serious problem, since development osteoporotic fractures fraught sharp deterioration status significant...
Postcovid syndrome (PCS) is a complex multifactorial clinical condition that frequent complication of COVID-19. The development PCS does not depend on the severity initial infectious disease, it has pronounced effect quality life and characterized by tendency to protracted course. In context ongoing COVID-19 pandemic, emergence new variants SARS-CoV-2 virus, important develop common approaches diagnosis management patients suffering from this medical condition. review presents current data...
Human aging is associated with an increased risk of various geriatric syndromes, cognitive impairment being among the most frequent. The prominent form — dementia has become one major course dependency in older and oldest old patients. Nevertheless, it been shown that despite fact parts brain change structurally over time due to natural or diseases, does not necessarily manifest into clinical symptoms for some people. Therefore, there a dissociation severity morphological functional changes....
The increase in the diabetes mellitus (DM) prevalence and incidence has taken on features of epidemic. Particularly often, DM occurs elderly senile patients, while at least half cases this population remain undiagnosed. contributes to deterioration quality life, causes formation dependence progression various geriatric syndromes leading increased mortality. Elderly age is an independent risk factor for diabetic neuropathy. main clinical forms which are represented by chronic sensorimotor...