Abstract Background Heart failure (HF) is a critical complication in elderly patients with atrial fibrillation (AF) and diabetes mellitus (DM). Recent preclinical studies suggested that non-vitamin K antagonist oral anticoagulants (NOACs) can potentially suppress the progression of cardiac fibrosis ischemic cardiomyopathy. Whether different influence risk HF older adults AF DM unknown. This study aimed to evaluate who were administered NOACs or warfarin. Methods A nationwide retrospective...

To evaluate the fracture risk among patients with atrial fibrillation (AF) treated non-vitamin K antagonist oral anticoagulants (NOACs) or warfarin.We conducted a real-world nationwide retrospective cohort study using Taiwan's National Health Insurance Research Database. All adult in Taiwan newly diagnosed AF between 2012 and 2016 who received NOACs warfarin were enrolled followed up until 2017. Patients sub-grouped according to NOAC used (dabigatran, rivaroxaban, apixaban). Propensity score...

Background Warfarin, a vitamin K antagonist, has been shown to affect bone mineral density and cause osteoporosis. However, studies investigating the relationship between non-vitamin antagonist oral anticoagulants (NOACs) osteoporosis are limited. We thus compared risk of in patients with atrial fibrillation treated either NOACs or warfarin. Methods Results This nationwide, retrospective cohort study used Taiwan's National Health Insurance Research Database. All adult Taiwan who were newly...

Background A higher risk of developing dementia is observed in patients with atrial fibrillation (AF). Results are inconsistent regarding the when AF use different anticoagulants. We aimed to investigate receiving non‐vitamin K antagonist oral anticoagulants (NOACs) compared those warfarin. Methods and conducted a nationwide population‐based cohort study incident cases using Taiwan National Health Insurance Research Database. initially enlisted all then selected treated either NOACs or...

Evidence about the association between types of oral anticoagulants and hazards diabetes complications is limited in patients with atrial fibrillation (AF) mellitus (DM).To compare mortality AF DM receiving non-vitamin K antagonist (NOACs) those warfarin.A retrospective cohort study.Nationwide data obtained from Taiwan's National Health Insurance Research Database.Patients NOACs or warfarin 2012 2017 Taiwan were enrolled. Treatment groups determined by patients' first initiation...

Background The effect of holiday season admission for stroke on mortality has not been investigated. Thus, we aimed to evaluate whether “holiday season” and “weekend” effects exist risk admission. Methods Results A nationwide cohort study was conducted using Taiwan's National Health Insurance Research Database. We identified all patients admitted between 2011 2015 in Taiwan, categorized them according the date: (at least 4 days off) (n=3908), weekend (n=13 774), weekday (n=49 045). analyzed...

Abstract Aims Evidence regarding the risks of serious hypoglycaemia for patients with atrial fibrillation (AF) and diabetes mellitus (DM) taking antidiabetic medications concurrent non-vitamin K antagonist oral anticoagulants (NOACs) vs. warfarin is limited. This study aimed to investigate this knowledge gap. Methods results retrospective cohort used nationwide data from Taiwan's National Health Insurance Research Database included a total 56 774 adult treated between 1 January 2012 31...

To compare the risk of diabetes development in patients with atrial fibrillation (AF) treated non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin.We conducted a nationwide retrospective cohort study using Taiwan's National Health Insurance Research Database. Adult new onset AF, NOACs or warfarin between 2012 2016, were included. The NOAC was further divided into dabigatran, rivaroxaban apixaban groups. primary outcome incident requiring treatment antidiabetic drugs. Fine Gray...

Atrial fibrillation detected after stroke (AFDAS) has a lower risk of ischemic recurrence than known atrial (KAF). While the benefit oral anticoagulants (OAC) for preventing in KAF is well established, their role patients with AFDAS more controversial. This study aimed to evaluate association between OAC use and recurrent real-world setting. nationwide retrospective cohort was conducted using Taiwan National Health Insurance Research Database. Patients hospitalized first-ever confirmed...

Background Acute aortic dissection is a life-threatening condition associated with high mortality rate. Findings from previous studies addressing the “weekend effect” on rate an acute have been inconsistent. Furthermore, effect of admission for during holiday season has not previously investigated. Objective Our aim was to evaluate or weekends risk mortality. Methods We conducted retrospective analysis nationwide cohort data Taiwan’s National Health Insurance Research Database. collected all...

Coxiella burnetii is an obligate bacterial pathogen that causes Q fever. Cytomegalovirus (CMV) commonly exists as a latent infection in healthy people. Co-infection with both pathogens rare. We report immunocompetent 53-year-old male farmer who presented fulminant hepatic failure and acute renal failure. Empiric antibiotic treatment intravenous penicillin G levofloxacin were given, but functions continued to deteriorate. A subsequent test of serum immunoglobulin M was positive for CMV,...

Abstract Aims Sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) have off‐target effects on haemoconcentration and anti‐inflammation. The impact of SGLT‐2i the risk venous thromboembolism (VTE) in patients with diabetes mellitus (DM) remains unclear. This study aimed to evaluate newly diagnosed VTE DM using comparison dipeptidyl peptidase‐4 (DPP‐4i) or glucagon‐like peptide‐1 receptor agonists (GLP‐1RA). Materials Methods In this nationwide retrospective cohort study, we used data from...

Pyomyositis is a pyogenic infection of the skeletal muscles causing myalgia and fever in patients. Hematogenous seeding engendered by persistent bacteremia septic embolism usually underlying cause disease. Trauma, intravenous drug use, immunodeficiency are main predisposing factors. Obturator internus pyomyositis with sciatica has not previously been reported. We report rare case patient subacute bacterial endocarditis presenting left buttock pain sciatica. Computed tomography confirmed...

We aimed to describe the multiplicity of chronic diseases in Alzheimer disease (AD) a nested case-control study. used random sample 1 million individuals from year 2000 registration data Taiwan National Health Insurance program comorbid pattern among patients with dementia during 2001-2011. Incident was identified by International Classification Diseases, Ninth Revision, first ever coded after 2001. AD further restricted those treated cholinesterase inhibitors or memantine approved...

Previous studies in Western countries have shown that a hyperosmolar hyperglycemic state (HHS) is associated with an increased risk of venous thromboembolism (VTE); these cases, prophylactic anticoagulant treatment suggested. However, the association between HHS and VTE Asian populations remains undetermined. Therefore, we aimed to evaluate whether diabetic Taiwanese patients.This nationwide, population-based, retrospective cohort study was conducted using Taiwan National Health Insurance...

Skin is our first line of defense against harmful microbes. We aim to investigate if disruption this in the form cutaneous wounds will increase incidence rate (IR) infective endocarditis (IE) a population with diabetes mellitus (DM). performed retrospective population-based study using Taiwan's National Health Insurance Database from 2003 2019. Self-controlled case series (SCCS) was used association between and IE. Adult DM patients both (exposure) IE (outcome) overall period were included...

Abstract Patients with hepatocellular carcinoma (HCC) might be more vulnerable to develop stroke than other cancer patients because of HCC-associated coagulation dysfunction. However, limited studies have investigated the relationship between HCC and stroke. This nationwide population-based cohort study enrolled all diagnosed 2011 2015 from Taiwan Cancer Registry National Health Insurance Research Database; an age- sex-matched without was included. The primary outcome 1-year risk for...

We aimed to determine whether hospital admissions during an extended holiday period (Chinese New Year) and weekends were associated with increased mortality risk from pulmonary embolism (PE), compared on weekdays. conducted a nationwide retrospective cohort study using Taiwan's National Health Insurance Research Database. Data of newly diagnosed PEs the months January February 2001 2017 obtained patient records classified into three admission groups: Chinese Year (≥ 4 consecutive days),...

Abstract There is a lack of studies that concurrently differentiate the effect holiday season from weekend on mortality risk in patients with acute myocardial infarction (AMI). We evaluated among admitted AMI who underwent percutaneous coronary intervention, using data Taiwan National Health Insurance Research Database. Adult during January and February between 2013 2020 were enrolled classified into (using Chinese New Year seasons as an indicator) (n = 1729), 4725), weekday 14,583) groups...

Background Patients with type A aortic dissection (TAAD) have a high short‐term risk of stroke. However, whether patients TAAD an increased long‐term stroke is still undetermined, and our study aims to address this knowledge gap. Methods Results nationwide retrospective cohort was conducted using Taiwan's National Health Insurance Research Database. We included as well age‐ sex‐matched disease–free individuals between 2003 2016. Inverse probability treatment weighting performed balance...

Background Aneurysm of proximal thoracic aorta (pTAA) is an often indolent, yet fatal disease. Although advancements in aneurysmal repair techniques have increased long-term survival rates, studies proven that there are increases perioperative risk for stroke incidence after pTAA surgery. Conversely, little evidence regarding the individuals, which strongly influences morbidity, mortality, and usage antithrombotic agents. Methods Using Taiwan National Health Insurance Research Database, a...