A5006207821- Pain Mechanisms and Treatments
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Heart Rate Variability and Autonomic Control
- Metabolism, Diabetes, and Cancer
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Cardiovascular Syncope and Autonomic Disorders
- Diabetic Foot Ulcer Assessment and Management
- Clinical practice guidelines implementation
- Pancreatic function and diabetes
- Botulinum Toxin and Related Neurological Disorders
- Growth Hormone and Insulin-like Growth Factors
- Skin Diseases and Diabetes
- Vagus Nerve Stimulation Research
- Dietary Effects on Health
- Bioenergy crop production and management
- Pain Management and Opioid Use
- Peripheral Artery Disease Management
- Advanced Neuroimaging Techniques and Applications
- Milk Quality and Mastitis in Dairy Cows
- Fibromyalgia and Chronic Fatigue Syndrome Research
Steno Diabetes Centers
2018-2024
Aalborg University Hospital
1999-2024
Aalborg University
2015-2022
Steno Diabetes Center North Jutland
2019-2020
North Denmark Region
2019-2020
Aalborg Portland (Denmark)
2020
Sjællands Universitetshospital, Nykøbing F.
2020
Creative Research Enterprises (United States)
2019
Capital Region of Denmark
2019
University of Copenhagen
2019
Type 1 diabetes can be complicated with neuropathy that involves immune-mediated and inflammatory pathways. Glucagon-like peptide-1 receptor agonists such as liraglutide, have shown anti-inflammatory properties, thus we hypothesized long-term treatment liraglutide induced diminished inflammation improved neuronal function.The study was a randomized, double-blinded, placebo-controlled trial of adults type confirmed symmetrical polyneuropathy. They were randomly assigned (1:1) to receive...
The insulin tolerance test (ITT) is regarded as the most reliable provocative in diagnosis of growth hormone (GH) deficiency adults. In present study was evaluated by investigating range GH responses normal adult males and females intra-individual reproducibility test. Sixteen healthy non-obese adults, eight (median age 31.5 years) 31.8 were tested twice with ITT, a minimum 72 h between each day 3 10 their menstrual cycles. Adequate hypoglycemia achieved all cases median nadir blood glucose...
OBJECTIVE The vast number of antihyperglycemic medications and growing amount evidence make clinical decision making difficult. aim this study was to investigate the safety dual triple therapies for type 2 diabetes management with respect major adverse cardiovascular events, severe hypoglycemia, all-cause mortality in a real-life setting. RESEARCH DESIGN AND METHODS Cox regression models were constructed analyze 20 years data from Danish National Patient Registry effect on three end points....
Abstract Aims To compare a novel index of parasympathetic tone, cardiac vagal with established autonomic variables and to test the hypotheses that (1) tone would be associated time frequency domain measures heart rate (2) lower in people Type 1 diabetes than matched healthy cohort still neuropathy. Methods Cardiac is validated cardiometrically derived tone. It measured using standard three‐lead electrocardiogram which connects, via Bluetooth, smartphone application. A 5‐min resting recording...
Distal symmetrical polyneuropathy (DSPN) is a severe common long-term complication of type 1 diabetes caused by impaired sensory-motor nerve function. As chronic low-grade inflammation may be involved in the pathogenesis DSPN, we investigated circulating levels inflammatory markers individuals with and without DSPN. Furthermore, determined to what extent these factors correlated different peripheral sensory functions.Cross-sectional study.The study included 103 (n = 50) DSPN 53) as well...
This study sought to utilise participatory research methods identify the perspectives of people with diabetes regarding which outcomes were most important them. These findings then used support an expert working group representing multiple health sectors and healthcare disciplines establish a core set patient-important outcome constructs for use in routine care.26 family members recruited through purposive sampling participate interviews, focus groups, voting plenary activities order be part...
In this study we investigated brain morphology in adults with diabetic neuropathy. We aimed to characterize gray matter volume (GMV) and cortical thickness, explore associations between whole clinical characteristics. 46 type 1 diabetes distal symmetric peripheral neuropathy (DSPN) 28 healthy controls underwent magnetic resonance imaging scans. GMV thickness were estimated using voxel-/surface-based morphometry. Associations total characteristics explored. Adults DSPN had reduced compared...
Background Glucagon‐like peptide‐1 receptor agonists, such as liraglutide, reduce hyperglycaemia and induce weight loss are used a treatment in diabetes. However, common adverse effects include nausea, of appetite prolonged gastric emptying. It is not known whether these changes centrally generated or if liraglutide alters the enteric motility. Objective To investigate on gastrointestinal function symptoms. Methods A total 48 adults with type 1 diabetes confirmed distal symmetric...
The insulin tolerance test (ITT) is widely accepted as the method of choice to evaluate GH secretion capacity in adults with hypothalamic-pituitary disorders. However, not suitable elderly or patients cardiovascular disease seizure In recent years alternatives ITT have been introduced. purpose present study was investigate diagnostic outcome ITT, pyridostigmine plus GHRH (PD+GHRH) test, clonidine (CLO+GHRH) and insulin-like growth factor I (IGF-I) an unselected group disease. An evaluation...
Background: The objective was to identify the presence of cardiovascular autonomic neuropathy (CAN) in a cohort individuals with diabetes outpatient clinics from 4 different parts Denmark and explore difference between type 1 2 relation CAN. Methods: DAN-Study is Danish multicenter study focusing on diabetic neuropathy. Over period 12 months, 382 271 were tested for Patients randomly recruited during normal visits at hospitals. CAN quantified by performing 3 reflex tests (response standing,...
Abstract Background Although gastrointestinal (GI) symptoms are common in diabetes, they frequently do not correlate with measurable sensorimotor abnormalities. The wireless motility capsule (WMC) measures pressure, temperature, and pH as it traverses the GI tract wherefrom transit times indices derived. aim was to investigate whether changes (a) segmental times, (b) index, (c) cardiac vagal tone, or (d) presence/absence of peripheral neuropathy type 1 diabetes. Methods Gastrointestinal 104...
Thalamus is essential in processing of sensory information. This study explored the associations between thalamic volume and intra-thalamic metabolites to clinical experimental characteristics function adults with diabetic polyneuropathy.48 type 1 diabetes confirmed distal symmetric peripheral neuropathy (DPSN) 28 healthy controls participated a cross-sectional underwent brain magnetic resonance imaging scan. Estimates for were extracted using voxel-based morphometry...
Improvements in the digital capabilities of health systems provide new opportunities for integration patient-reported outcome (PRO) solutions routine care, which can facilitate delivery person-centered diabetes care. We undertook this study as part our development a PRO questionnaire and clinical dialog support tool use by people with their care professionals (HCPs) to improve quality outcomes.This evaluates feasibility, acceptability, perceived benefits impacts using tool, DiaProfil,...
Objective: The objective of this study was to elucidate whether the degree autonomic modulation is associated with microvascular complications in patients type 1 diabetes. Methods: A total 290 individuals diabetes were randomly recruited during normal visits outpatient clinics at 4 Danish hospitals. modulations quantified by measuring heart rate variability (HRV) passive spectral analysis and active tests (valsalva ratio [VT], response standing [RT], deep breathing [E:I]). To describe...
We hypothesized that adults with type 1 diabetes and severe polyneuropathy have alterations in neuronal transmission at different anatomical levels. The aims were to investigate upstream sensory activation terms of peripheral, spinal, precortical, cortical transmission.48 participants type-1 polyneuropathy, 21 age-matched healthy included. Electrophysiological median nerve recordings used analyze peripheral Erb's point (P9-N11); spinal evoked potentials Cv7 (P11-N14); subcortical Oz...
is a peer-reviewed open access academic journal that aims to guide clinical practice and improve diagnostic therapeutic skills of clinicians.WJD covers topics concerning α, β, δ PP cells the pancreatic islet, effect insulin insulinresistance, islet transplantation, adipose obesity.
Purpose: The superior and inferior tarsal muscles are sympathetically innervated smooth muscles. Long-term diabetes often leads to microvascular complications, such as, retinopathy autonomic neuropathy. We hypothesized that induces (1) sympathetic paresis in the this measure is associated with (2) severity of diabetic retinopathy, (3) duration diabetes, (4) function. In addition, association between function was investigated. Methods: Forty-eight participants long-term type 1 confirmed...
Comprehensive evaluation of the upstream sensory processing in diabetic symmetrical polyneuropathy (DSPN) is sparse. The authors investigated spinal nociceptive withdrawal reflex and related elicited somatosensory evoked cortical potentials. They hypothesized that DSPN induces alterations supraspinal sensory-motor compared with age- gender-matched healthy controls.In this study, 48 patients type 1 diabetes were 21 controls. Perception thresholds determined subjects received electrical...