A5026444444- Cancer, Stress, Anesthesia, and Immune Response
- Vagus Nerve Stimulation Research
- Axon Guidance and Neuronal Signaling
- Genomic variations and chromosomal abnormalities
- Congenital Ear and Nasal Anomalies
- Immunotherapy and Immune Responses
- Genetic and Kidney Cyst Diseases
- Chromatin Remodeling and Cancer
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic and Hepatic Oncology Research
- Autoimmune and Inflammatory Disorders
- Neuropeptides and Animal Physiology
- Neurogenetic and Muscular Disorders Research
- Prenatal Screening and Diagnostics
- CAR-T cell therapy research
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Renal and related cancers
- Pediatric Pain Management Techniques
- Genomics and Rare Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
Aix-Marseille Université
2022-2024
Centre National de la Recherche Scientifique
2022-2024
Institut de Biologie du Développement Marseille
2022
Universidad Autónoma de Nuevo León
2017-2020
University of Monterrey
2020
Abstract Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, origin of intra-tumoral nerves remains poorly known, part because technical difficulties tracing fibers via conventional histological preparations. Here, we employ three-dimensional (3D) imaging cleared tissues for a comprehensive analysis sympathetic innervation murine model pancreatic ductal adenocarcinoma (PDAC). Our results support two independent, but coexisting, mechanisms: passive...
Abstract The peripheral nervous system is a key regulator of cancer progression. In pancreatic ductal adenocarcinoma (PDAC), the sympathetic branch autonomic inhibits development. This inhibition associated with extensive nerve sprouting in early precursor lesions. However, underlying mechanisms behind this process remain unclear. study aimed to investigate roles Schwann cells structural plasticity neurons. We examined changes number and distribution transgenic mouse model PDAC metaplastic...
Abstract Blau syndrome (BS) is a rare, chronic autoinflammatory disease with onset before age 4 and mainly characterised by granulomatous arthritis, recurrent uveitis, skin rash. Sporadic (also known as early-onset sarcoidosis) or familial BS caused gain-of-function mutations in the NOD2 gene, which encodes for multi-task protein that plays crucial role innate immune defense. We report on three Mexican patients clinically diagnosed who exhibited likely pathogenic variant revealed whole-exome...
VPS35 is a core component of the retromer complex involved in familial forms neurodegenerative diseases such as Parkinson's and Alzheimer's disease. In mice, expressed during early brain development. However, previous studies have reported that activity largely dispensable for normal neuronal development initial elaboration axonal projections. Here, we evaluated role mouse embryonic using two Cre-driver lines remove Vps35 from cortex at different prenatal stages. We found mutant mice...
Splicing-related gene mutations might affect the expression of a single or multiple genes and cause clinically heterogeneous diseases. With advent next-generation sequencing, several splicing have been exposed, yet most major spliceosome no reports germline therefore, their effects are largely unknown. We describe previously unreported concurrence intellectual disability, short stature, poor speech, minor craniofacial hand anomalies in 2 female siblings with 3 homozygous missense variants...
“Simple” 1-way interchromosomal insertions involving an interstitial 1q segment are rare, and therefore, their characterization at the base pair level remains understudied. Here, we describe genomic of a previously unreported de novo insertion (3;1) entailing about 12-Mb pure gain 1q21.3q23.3 that causes typical (microcephaly, developmental delay, facial dysmorphism) atypical (interauricular communication, small feet with bilateral deep plantar creases, syndactyly II-IV toes, mild...
ABSTRACT The peripheral nervous system is a key regulator of cancer progression. In pancreatic ductal adenocarcinoma (PDAC), the sympathetic branch autonomic inhibits development. This inhibition associated with extensive nerve sprouting in early precursor lesions. However, underlying mechanisms behind this process remain unclear. study aimed to investigate roles Schwann cells structural plasticity neurons. We examined changes number and distribution transgenic mouse model PDAC metaplastic...