A5087238227- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Head and Neck Surgical Oncology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
- Restraint-Related Deaths
- Cystic Fibrosis Research Advances
- Oral and Maxillofacial Pathology
- Trauma Management and Diagnosis
- Antimicrobial Peptides and Activities
- Drug-Induced Adverse Reactions
- Traumatic Ocular and Foreign Body Injuries
- Pediatric health and respiratory diseases
- Congenital Ear and Nasal Anomalies
- Infectious Diseases and Mycology
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Head and Neck Anomalies
- Nasal Surgery and Airway Studies
- Bone and Dental Protein Studies
Showa University
2016-2025
Red Cross Hospital
2021
Krankenhaus vom Roten Kreuz
2021
Children's Hospital of Richmond at VCU
2017-2020
Virginia Commonwealth University
2016-2020
Showa University Northern Yokohama Hospital
2012
Northern Hospital
2012
Abstract Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small-to-medium vessel asthma, rhinosinusitis, eosinophilia. EGPA often difficult to distinguish from severe asthma eosinophilic chronic rhinosinusitis (ECRS) in cases when there are no findings that suggest vasculitis. Dupilumab, an anti-IL-4Rα monoclonal antibody, expected be...
Primary ciliary dyskinesia (PCD) is a relatively rare genetic disorder that affects approximately 1 in 20,000 people. Approximately 50 genes are currently known to cause PCD. In light of differences causative and the medical system Japan compared with other countries, practical guide was needed for diagnosis management Japanese PCD patients.
Periostin is an extracellular matrix protein that highly expressed in nasal polyp (NP) tissues patients with chronic rhinosinusitis (CRS). This study investigated the cellular source of periostin sinonasal and mechanism IL-13-induced production epithelial cells. The amount localization mRNA were examined via immunohistochemistry situ hybridization analysis control subjects eosinophilic (ECRS) non-ECRS. expression levels type 2 inflammatory cytokines tissue measured by levels. Normal human...
Serum periostin is increased in asthma and serves as a surrogate marker for IL-13 activity the lung. levels of are most robust biomarker predicting favourable response to anti-IL-13 drug, lebrikizumab. We investigated mechanisms stimulation periostin, polarized secretion whether would have direct effect on mucin by airway cells.Normal human bronchial epithelial (NHBE) cells were cultured at air-liquid interface (ALI) presence IL-13, we evaluated specific inhibitors, leflunomide (Janus kinase...
COPD is characterized by persistent and progressive airway inflammation. Although neutrophilic inflammation generally accepted to be a major factor in the pathogenesis of COPD, influence agents used for treatment on neutrophil functions such as chemotaxis not fully understood.The present study aimed examine tiotropium bromide production interleukin (IL)-8 from human epithelial cells lung fibroblasts (LFs) after lipopolysaccharide (LPS) stimulation vitro.BEAS-2B cells, bronchial cell line,...
Purpose: The status of dupilumab self-injection at home is not well understood. We therefore aimed to identify the barriers adherence self-injection. Patients and Methods: This non-interventional open-label study was conducted between March 2021 July 2021. with atopic dermatitis, bronchial asthma, chronic rhinosinusitis nasal polyps receiving dupilumab, from 15 sites, were requested complete a self-administered questionnaire regarding frequency effectiveness dosing as their use satisfaction...
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BACKGROUND:Primary ciliary dyskinesia (PCD) is a rare genetic disease associated with abnormalities in the structure and function of cilia. The common clinical presentation PCD characterized by otitis media, chronic rhinosinusitis (CRS), bronchitis, infertility due to impaired motility. complex its diagnosis complicated. However, there are some features that strong indicators PCD, namely situs inversus, CRS, bronchitis wet cough. CASE REPORT:A 49-year-old male who had already received 3...
Sublingual immunotherapy is a widely used treatment, and serious adverse reactions such as anaphylaxis are rare. We report two cases of laryngeal edema to sublingual immunotherapy, which could be continued due change in the administration method. Case 1 presents 15-year-old male suspected have had dust at age 6 years. He started treatment with Miticure