A5088157899- Eating Disorders and Behaviors
- Data Management and Algorithms
- Sexual function and dysfunction studies
- Data Visualization and Analytics
- Protein Degradation and Inhibitors
- Pediatric Hepatobiliary Diseases and Treatments
- Ubiquitin and proteasome pathways
- Heart Rate Variability and Autonomic Control
- Advanced Database Systems and Queries
- Cellular Automata and Applications
- Evolutionary Psychology and Human Behavior
- Psychosomatic Disorders and Their Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Geographic Information Systems Studies
- Peptidase Inhibition and Analysis
- History of Education Research in Brazil
- Gallbladder and Bile Duct Disorders
- Consumer Perception and Purchasing Behavior
- Sexuality, Behavior, and Technology
- Histone Deacetylase Inhibitors Research
- Health, Nursing, Elderly Care
- Obstructive Sleep Apnea Research
- Cultural Insights and Digital Impacts
- Education Pedagogy and Practices
- Advanced Drug Delivery Systems
CHU Ambroise Paré
2024
Aix-Marseille Université
2022
Biologie Tissulaire et Ingénierie Thérapeutique
2020-2021
Université Claude Bernard Lyon 1
2020-2021
Centre National de la Recherche Scientifique
2020-2021
ISPA - Instituto Universitário
2016-2021
Hospital Santa Luzia
2020
Hospital Braga
2020
Pontifícia Universidade Católica de Minas Gerais
2020
University of Birmingham
2010-2017
Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4, BRDT) are transcriptional regulators required for efficient expression of several growth promoting antiapoptotic genes as well cell-cycle progression. BET recruited on transcriptionally active chromatin via their two N-terminal bromodomains (BRD), a protein interaction module that specifically recognizes acetylated lysine residues in histones H3 H4. Inhibition the BET-histone results downregulation number oncogenes, providing novel...
Sixty-five consecutive elderly patients (mean age 78 years) referred to a 'syncope' clinic over six-month period were prospectively studied. Initial evaluation included ambulatory electrocardiography, carotid sinus massage before and after atropine prolonged head-up tilt. Diagnostic criteria for causes of syncope assigned at the beginning study. Overall, diagnosis was attributed symptoms in 92% patients; overlap present quarter. Diagnoses cardioinhibitory syndrome (CSS; 5%), vasodepressor...
Abstract Background After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode growth is mostly responsible chronic that current therapeutics fail to cure and it well-established novel strategies must be investigated. Particulate drug delivery systems are considered as promising strategy face issues related treatments in context. Particularly, poly-lactic acid (PLA) nanoparticles present great interest...
Paediatric B-precursor ALL is a highly curable disease, however, treatment resistance in some patients and the long-term toxic effects of current therapies pose need for more targeted therapeutic approaches. We addressed cytotoxic effect JQ1, selective inhibitor against transcriptional regulators, bromodomain extra-terminal (BET) family proteins, paediatric ALL. showed potent vitro response panel primary to independent their prognostic features but dependent on high MYC expression coupled...
Nanocomposite fibrin-based hydrogel with antibacterial and antibiofilm properties, safe for dental pulp mesenchymal stem cells.
The objectives of this study were to develop a unified Portuguese-language version, for use in Brazil and Portugal, the Body Shape Questionnaire (BSQ) estimate its validity, reliability, internal consistency Brazilian Portuguese female university students. Confirmatory factor analysis was performed using both original (34-item) shortened (8-item) versions. model's fit assessed with χ²/df, CFI, NFI, RMSEA. Concurrent convergent validity assessed. Reliability estimated through composite...
Introduction REM sleep deprivation increases unstimulated erections in rats, and total during audiovisual sexual stimulation men, but the effects of problems on human arousal are unknown. Objective We examined associations subjective quality with arousal, satisfaction sex life, frequency desire over past month. Methods 275 Portuguese (169 women) reported their anxiety, a resting state, completed Pittsburgh Sleep Quality Index, subscale LiSat scale, Desire dimensions Female Sexual Function...
To assess treatment with fludrocortisone in vasodepressor carotid sinus syndrome.Eleven patients, mean (SD) age 83 (5) years, daily dizzy episodes and a median of five (range two to 20) syncopal over one year were studied. All had syndrome (> 50 mm Hg fall systolic blood pressure during massage independent bradycardia). Carotid was carried out while the patient supine upright (tilt table) before after 600 micrograms intravenous atropine. Phasic heart rate recordings monitored throughout. The...
Poly(lactic acid) (PLA) nanoparticles (NPs) are widely investigated due to their bioresorbable, biocompatible and low immunogen properties. Interestingly, many recent studies show that they can be efficiently used as drug delivery systems or adjuvants enhance vaccine efficacy. Our work focuses on the molecular mechanisms involved during nanoprecipitation of PLA NPs from concentrated solutions lactic acid polymeric chains, specific interactions with biologically relevant molecules. In this...
Self-forgetfulness is a facet of self-transcendence characterized by tendency to experience altered states consciousness. We examined associations self-forgetfulness with sexual desire and frequency. Two hundred sixty-one Portuguese men women completed the subscale Temperament Character Inventory-Revised, measure openness experience, questionnaire on desired actual frequency vaginal intercourse, noncoital sex, masturbation in past month. In simple partial correlations controlling for...
We report a patient with posterior circulation stroke that presented insidiously, progressed rapidly and had an unusual aetiology of vertebral giant cell arteritis was not recognised in timely fashion. General awareness this cause might alert clinicians to consider the diagnosis similar cases, as prompt intervention may improve outcomes.
The increased survival of infants born at extremely low birthweight (ELBW) has been associated with significant morbidity, including higher rates neurodevelopmental disability. However, formalized testing to evaluate these problems is both time-consuming and costly. revised Functional Status questionnaire (FS-II) was designed assess caregivers' perceptions the functional status children chronic diseases.We evaluated reliability validity FS-II for ELBWinfants 18 22 months corrected age using...
Introduction:The main objective of this study was to understand the impact caffeine on adolescents' health and related behaviours, namely sleep duration quality life.Methods: Students in 6 th , 8 10 grades were chosen randomly from clusters schools for study.A questionnaire designed measure consumption, quantity life used.
Introdução: todo ano cerca de 650 mil brasileiros ingressam na chamada terceira idade. Atualmente, percebe-se maior prevalência doenças crônico-degenerativas, interferindo qualidade vida (QV) desses idosos. Objetivo: verificar a QV do servidor federal que se encontra fase da senescência, atuante em instituição situada no sul Estado Paraná. Materiais e métodos: participaram estudo 36 servidores docentes, técnicos administrativos terceirizados, ambos os sexos, com faixa etária entre 40 57...
Este artigo propõe-se a discutir ética na visão de Habermas. No trabalho, vamos explicar como Habermas constrói sua Ética do Discurso partir uma reformulação da Imperativo Categórico Kant. Isso porque, tal para Kant, também compreende que as normas morais devem ser passíveis universalização. entanto, o filósofo pragmatismo, essa universalização não é mais resultado reflexão monológica sujeito, mas discurso.