A5043746958- Chronic Lymphocytic Leukemia Research
- Liver physiology and pathology
- Aldose Reductase and Taurine
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroendocrine Tumor Research Advances
- Prenatal Substance Exposure Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- PI3K/AKT/mTOR signaling in cancer
- Cannabis and Cannabinoid Research
- Mesenchymal stem cell research
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Diagnosis and treatment of tuberculosis
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Intestinal and Peritoneal Adhesions
- Horticultural and Viticultural Research
- Liver Disease Diagnosis and Treatment
University of Birmingham
2012-2024
Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif
2018
University of Liverpool
1992-2015
NIHR Birmingham Liver Biomedical Research Unit
2012
Queen Elizabeth Hospital Birmingham
2012
National Institute for Health Research
2012
Centers for Disease Control and Prevention
2002
AstraZeneca (United Kingdom)
2001
St Mark's Hospital
1992
Royal Brompton Hospital
1984
Abstract Background Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in progression prostate, breast, endometrial and leukemic cancers. This is due to ability AKR1C modify androgens, estrogens, progesterone prostaglandins (PGs) a tissue-specific manner, regulating activity nuclear receptors other downstream effects. Evidence supporting role for cancer derives mostly from studies with isolated primary cells patients or immortalized cell lines. Mice...
Background The majority of acute myeloid leukaemia (AML) patients are over sixty years age. With current treatment regimens, survival rates amongst these, and also those younger who relapse, remain dismal novel therapies urgently required. In particular, that have anti-leukaemic activity but that, unlike conventional chemotherapy, do not impair normal haemopoiesis. Principal Findings Here we demonstrate the potent combination lipid-regulating drug bezafibrate (BEZ) sex hormone...
Human bone marrow mesenchymal stem cells (hMSCs) have shown benefit in clinical trials of patients with liver disease. Efficient delivery to target organs is critical improving their effectiveness. This requires an understanding the mechanisms governing cellular engraftment into liver. Binding hMSCs normal/injured tissue, purified extracellular matrices, and human hepatic sinusoidal endothelial (HSECs) were quantified static flow conditions. To define underpinning hMSC interactions,...
Abstract Members of the aldo-keto reductase (AKR) superfamily, particularly AKR1C subfamily, are emerging as important mediators pathology cancer. Agents that inhibit these enzymes may provide novel agents for either chemoprevention or treatment diverse malignancies. Recently, jasmonates, a family plant stress hormones bear structural resemblance to prostaglandins, have been shown elicit anticancer activities both in vitro and vivo. In this study, we show jasmonic acid (JA) methyl jasmonate...
To investigate the involvement of candidate cytokine genes in pathogenesis juvenile idiopathic arthritis (JIA).Single nucleotide polymorphisms and intragenic microsatellite markers within 8 (interleukin-1alpha [IL-1alpha], IL-2, IL-4, IL-6, IL-10, interferon-alpha1 [IFNA1], interferon-gamma [IFNG], interferon regulatory factor 1 [IRF-1]) were investigated 417 Caucasian patients with clinically characterized JIA a panel 276 unrelated, healthy controls, all from United Kingdom.A novel...
We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer leukaemia. As consequence, significant effort is being invested development of AKR1C3-selective inhibitors. report screening an in-house library to identify known drugs that selectively inhibit over closely related isoforms AKR1C1, 1C2 1C4. This screen initially tetracycline inhibitor. However, mass spectrometry nuclear magnetic resonance studies active agent was novel...
// Elizabeth K. Marsh 1, 4 , Craig P. Delury 1 Nicholas J. Davies Christopher Weston 2 Mohammed A. L. Miah Lawrence Banks 3 Joanna Parish Martin R. Higgs * Sally Roberts Institute of Cancer and Genomic Sciences, University Birmingham, United Kingdom Immunology Immunotherapy, International Centre for Genetic Engineering Biotechnology, Padriciano, Trieste, Italy Present address: Faculty Medicine, Dentistry Health, Sheffield, These authors have contributed equally to this work Correspondence...
// Nicholas J. Davies 1 , Marwan Kwok Clive Gould 2 Ceri E. Oldreive Jingwen Mao Helen Parry 3 Edward Smith Angelo Agathanggelou Guy Pratt Alexander Malcolm R. Taylor Paul Moss Mike Griffiths 1, and Tatjana Stankovic Institute of Cancer Genomic Sciences, University Birmingham, UK West Midlands Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust, Immunology Immunotherapy, Correspondence to: Stankovic, email: t.stankovic@bham.ac.uk Keywords: chronic lymphocytic leukemia,...
Diffuse large B-cell lymphoma (DLBCL) is the most common malignancy that develops in patients with ataxia-telangiectasia, a cancer-predisposing inherited syndrome characterized by inactivating germline ATM mutations. also frequently mutated sporadic DLBCL. To investigate lymphomagenic mechanisms and lymphoma-specific dependencies underlying defective ATM, we applied ribonucleic acid (RNA)-seq genome-scale loss-offunction clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9...
Pulmonary and systemic blood flow pulmonary vascular resistance were measured in 21 children with congenital heart disease. Blood was calculated by the direct Fick method, using measurements of metabolic gas exchange obtained remote respiratory mass spectrometry. The observations showed that administration oxygen caused an appreciable fall 16 studied this would not have been appreciated from a study arterial pressure alone as it masked corresponding rise flow. In 10 14 children, whom...
Journal Article Early results with the Lichtenstein tension-free hernia repair Get access N Davies, Davies Department of Surgery, University Liverpool, UK Search for other works by this author on: Oxford Academic Google Scholar M Thomas, Thomas B McIlroy, McIlroy A Kingsnorth Correspondence to: Mr A. N. Kingsnorth, Royal Liverpool Hospital, L7 8XP, British Volume 81, Issue 10, October 1994, Pages 1478–1479, https://doi.org/10.1002/bjs.1800811025 Published: 08 December 2005 history Accepted:...
Chronic lymphocytic leukaemia (CLL) cells require micorenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts the presence of T-cells and other supporting cells. Current primary CLL xenograft models suffer from limited duration tumour cell engraftment coupled with gradual T-cell outgrowth. Thus, a greater understanding interaction between could improve utility. In this study, using two distinct models, we investigated whether xenografts...
The advent of functional genomics has enabled the genome-wide characterization molecular state cells and tissues, virtually at every level biological organization. difficulty in organizing mining this unprecedented amount information stimulated development computational methods designed to infer underlying structure regulatory networks from observational data. These important developments had a profound impact sciences since they triggered novel data-driven investigative approach. In cancer...
Abstract A study was performed to assess the effects of octreotide on growth and development liver metastases in rats. Tumour induced by intraportal injection three tumorigenic cell lines (the fibrosarcoma HSN colonic adenocarcinomas K12/Tr WB2054M) syngeneic Octreotide treatment (2 μg subcutaneously for 3 or 4 weeks) started 18 h 1 week after tumour induction; a delay allowed micrometastases develop. Treatment with significantly (P < 0.001) reduced median hepatic replacement compared...