A5011971205- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Immune responses and vaccinations
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Biofuel production and bioconversion
- Hemoglobin structure and function
- Electronic Health Records Systems
- GABA and Rice Research
- Amino Acid Enzymes and Metabolism
- Reproductive tract infections research
- Polyamine Metabolism and Applications
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Enzyme Production and Characterization
- Cholinesterase and Neurodegenerative Diseases
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Image Retrieval and Classification Techniques
- Medical Coding and Health Information
- Pharmacogenetics and Drug Metabolism
National Institute of Allergy and Infectious Diseases
2025
National Institutes of Health
2022-2024
National Human Genome Research Institute
2024
Washington University in St. Louis
2021
Sam Higginbottom Institute of Agriculture
2010-2019
University of Birmingham
1973-2019
University of Allahabad
2017
Charing Cross Hospital
1990
Royal College of General Practitioners
1972-1974
Extremely premature infants (EPIs) who are born before 30 weeks of gestation susceptible to infection; however, the trajectory their peripheral immunity is poorly understood. Here, we undertook longitudinal analyses immune cells from 250 μl whole blood at 1 week, month, and 2 months 10 EPIs compared these with samples healthy adults preterm full-term cord samples. Single-cell suspensions individual were split perform single-cell RNA sequencing, T B cell receptor phosphoprotein mass...
STUDY OBJECTIVE--The aim was to evaluate the current approach forecasting hospital bed requirements. DESIGN--The study a time series and regression analysis. The for mean duration of stay general surgery in age group 15-44 years (1969-1982) used evaluation different methods future values its subsequent use formation RESULTS--It has been suggested that simple trend fitting suffers from model specification error imposes unjustified restrictions on data. Time (Box-Jenkins method) shown be more...
We leveraged specimens from the RV217 prospective study that enrolled participants at high risk of HIV-1 acquisition to investigate how NK, conventional T cells, and unconventional cells influence acquisition. observed low levels α4β7 expression on memory CD4 iNKT two cell types highly susceptible infection, in exposed seronegative (HESN) compared seroconverter (HESC) participants. NK HESN had higher HESC, presented a quiescent phenotype, capacity respond opsonized target cells. also...
We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer leukaemia. As consequence, significant effort is being invested development of AKR1C3-selective inhibitors. report screening an in-house library to identify known drugs that selectively inhibit over closely related isoforms AKR1C1, 1C2 1C4. This screen initially tetracycline inhibitor. However, mass spectrometry nuclear magnetic resonance studies active agent was novel...
Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides non-ribosomal peptides. These mediate the production of many pharmaceutically important compounds including antibiotics anticancer agents. Acyl carrier (ACPs) can be found part a multi-domain polypeptide (Type I ACPs), or multiprotein complex II). Here, main focus is on ACP2 ACP3, domains from type trans-AT polyketide synthase MmpA, which core component...
In our presented research, we made an attempt to predict the 3D model for cysteine synthase ( A2GMG5_TRIVA ) using homology-modeling approaches. To investigate deeper into predicted structure, further performed a molecular dynamics simulation 10 ns and calculated several supporting analysis structural properties such as RMSF, radius of gyration, total energy calculation support structured synthase. The present findings led us conclude that proposed is stereochemically stable. overall...
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that can infect a wide range of warm-blooded animals including humans.In humans and other intermediate hosts, toxoplasma develops into chronic infection cannot be eliminated by host's immune response or currently used drugs.In most cases, infections are largely asymptomatic unless the host becomes compromised.Thus, global health problem situation has become more precarious due to advent HIV poor toleration drugs treat...
Suicide mortality in the area now administered by Greater London Council was assessed for three five-year periods 1949-1953, 1959-63, and 1969-73. For each of standard ratio (SMR) suicide various boroughs calculated men women separately. The with high SMRs were constant. There a pronounced change geographical distribution among women. These findings support hypothesis that determinants differ between sexes.
Successful record linkage is dependent upon adequate identification of individuals. Acheson (1967) has stated the five fundamental criteria that should be fulfilled by an system: it provide unique, permanent each member population; available on any pair records to linked, and economical, i.e., consist no more characters information than necessary. He reviewed numbering systems currently in use, one fulfils three his National Health Service number. It provides perma nent which covers...
Chickpea is a premier food legume crop with high nutritional quality and attains prime importance in the current era of 795 million people being undernourished worldwide. production encounters setbacks due to various stresses understanding role key transcription factors (TFs) involved multiple becomes inevitable. We have recently identified multi-stress responsive WRKY TF chickpea. The present study was conducted predict structure identify DNA-interacting residues decipher DNA-protein...
Trichomonas vaginalis causes trichomoniasis, second most sexually transmitted disease.The genome sequence draft of T. was published by The Institute Genomic Research reveals an abnormally large size 160 Mb.It speculated that a significant portion the proteome contains paralogous proteins.The present study aimed at identification and analysis all against search approach is used to identify dataset proteins retrieved from TIGR TrichDB FTP server.The BLAST-P program performed database searches...
Abstract Advances in multimodal single cell analysis can empower high-resolution dissection of human vaccination responses. The resulting data capture multiple layers biological variations, including molecular and cellular states, vaccine formulations, inter- intra-subject differences, responses unfolding over time. Transforming such into insight remains a major challenge. Here we present systematic framework applied to obtained before after influenza without adjuvants or pandemic H5N1 with...
AmpC is a group I, class C -lactamase present in most Enterobacteriaceae and Pseudomonas aeruginosa other nonfermenting gram-negative bacilli. The β-lactam of antibiotics one the important structural classes antibacterial compounds act by inhibiting bacterial D ,D - transpeptidases that are responsible for final step peptidoglycan cross-linking. Our main aim study to screen possible inhibitors against / β lactamase (an enzyme antimicrobial activity aeruginosa), through virtual screening 1364...
The general practitioner through his contract with the local Executive Council is responsible for medical care of a named group people. Additionally he may from time to accept responsibility temporary residents. average has 2,500 3,000 patients on list, and any one these consult him at time. Thus in records system it necessary maintain an 'active file' available short notice all persons registered. This presents different problem that hospital where most transactions are covered by...
An investigation of the accuracy general practitioner and Executive Council files was approached by a comparison two. High error rates were found, including both file errors record errors. On analysis it emerged that could not be satisfactorily expressed except in time-dimensioned way, we unable to do this within context our study. Record field expressible as proportions number records on lists; 79·2% all exhibited non-congruencies particular information fields had ranging from 0·8%...
Ornithine decarboxylase (ODC) enzyme, catalyses the decarboxylation of ornithine to form spermidine which is a committed step in biosynthesis polyamines. Here, present work, structure ODC was modelled and studied for its active site. The stability revalidated by molecular dynamics simulation at 50 nano second time scale. 142 Natural products Indofine Herbal Ingredient library from ZINC database were screened using Autodock Vina identification potential leading herbal inhibitors. results...