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Jessica A. Herstine

ORCID: 0000-0002-9108-1840
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About
Contact & Profiles
A5092820241
Research Areas
  • RNA regulation and disease
  • Virus-based gene therapy research
  • RNA and protein synthesis mechanisms
  • interferon and immune responses
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • RNA Research and Splicing
  • Cancer-related molecular mechanisms research

The Ohio State University
 2024

Nationwide Children's Hospital
 2023-2024

University of California, Davis
 2024

Office of Infectious Diseases
 2024

 Evaluation of safety and early efficacy of AAV gene therapy in mouse models of vanishing white matter disease
OPENALEX - Publications 
Jessica A. Herstine Pi-Kai Chang Sergiy Chornyy Tamara J. Stevenson Alex Sunshine and 12 more Ksenia Nokhrina Jessica Rediger Julia Wentz Tatyana A. Vetter E Schöll Caleb Holaway Nettie K. Pyne Anna Bratasz Stewart Yeoh Kevin M. Flanigan Joshua L. Bonkowsky Allison M. Bradbury

10.1016/j.ymthe.2024.03.034 article EN Molecular Therapy 2024-03-27
 400 Investigation of a translational astrocyte-targeted AAV-mediated gene addition therapy in two models of Vanishing White Matter disease
OPENALEX - Publications 
Jessica A. Herstine Pi-Kai Chang Sergiy Chornyy Tamara J. Stevenson Jessica Rediger and 4 more Julia Wentz Nettie K. Pyne Joshua L. Bonkowsky Allison M. Bradbury

OBJECTIVES/GOALS: Vanishing White Matter Disease (VWM), is a childhood neurodegenerative leukodystrophy that presents with motor deficits, neurologic decline, and seizures leading to death.There are no treatments. Herein we investigate adeno-associated virus serotype 9 (AAV9) gene addition therapy for VWM. METHODS/STUDY POPULATION: To serve as baseline disease correction, characterized the severe VWM Eif2b5 I98M murine model clinically relevant readouts including function, gait mapping...

10.1017/cts.2024.348 article EN cc-by-nc-nd Journal of Clinical and Translational Science 2024-04-01
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