A5044900342- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycobacterium research and diagnosis
Weizmann Institute of Science
2021-2023
During productive human cytomegalovirus (HCMV) infection, viral genes are expressed in a coordinated cascade that conventionally relies on the dependencies of protein synthesis and DNA replication. By contrast, transcriptional landscape HCMV latency is poorly understood. Here, we examine gene expression dynamics during establishment both latent infections. We redefine kinetics infection reveal regulation does not represent simple sequential cascade; many regulated by multiple independent...
Abstract Primary infection with Human cytomegalovirus (HCMV) results in a persistent lifelong due to its ability establish latent infection. During productive HCMV infection, viral genes are expressed coordinated cascade that is characteristic of all herpesviruses and traditionally relies on the dependencies protein synthesis DNA replication. In contrast, transcriptional landscape associated latency still disputed poorly understood. Here, we examine transcriptomic dynamics during...
Abstract Infection with Human cytomegalovirus (HCMV) can result in either productive or non-productive infection, the latter potentially leading to establishment of latency, but molecular factors that dictate these different infection outcomes are elusive. Macrophages known targets HCMV and considered be permissive for while monocytes, their precursors, latently infected. Here we reveal macrophages is more complex than previously appreciated infection. By analyzing progression monocytes...