A5054846306- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Luminescence Properties of Advanced Materials
- Conducting polymers and applications
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Adsorption, diffusion, and thermodynamic properties of materials
- Synthesis and biological activity
- Environmental Toxicology and Ecotoxicology
- Dendrimers and Hyperbranched Polymers
- Surfactants and Colloidal Systems
- Transgenic Plants and Applications
- Advanced biosensing and bioanalysis techniques
- Perovskite Materials and Applications
- Iron oxide chemistry and applications
- Catalysis and Oxidation Reactions
- biodegradable polymer synthesis and properties
- Synthesis and properties of polymers
- Advancements in Battery Materials
- Plant tissue culture and regeneration
Lviv Polytechnic National University
2015-2024
Vladimir State University
2019
Moscow State University of Fine Chemical Technologies
2015
Polytechnic University
2013
Lviv University
2012
National University
2010
Nanopowders of LaPO4 have been grown by sedimentation-micellar method. As-prepared nanoparticles with the average grain size about 8 nm a single-phase hydrated hexagonal structure. After thermal annealing at 600 and 800 °C, increases up to ∼35 ∼50 nm, respectively, structure transforms into monoclinic. IR spectra different were investigated in wide range wavenumbers from 130 5000 cm−1 20–300 K temperature region. Differences between bulk material as well behavior vibrational properties are discussed.
Ruthenium anticancer drugs belong to the most promising non-platinum metal compounds in clinical evaluation. However, although results are regarding both activity and very low adverse effects, application is currently hampered by limited solubility stability of drug aqueous solution. Here, we present a new nanoparticle formulation based on polymer-based micelles loaded with lead ruthenium compound KP1019. Nanoprepared KP1019 was characterised enhanced solutions. Moreover, facilitated...
The study of the spectral-luminescence parameters LaPO4-Eu and LaPO4-Pr nanoparticles upon excitation by synchrotron radiation with photon energies 4–40 eV was performed. differences luminescence intensity dependence on size for excited at range matrix transparency, band-to-band transitions, electronic multiplication were revealed. observed regularities are explained in terms electron-phonon electron-electron scattering, surface losses, exciton diffusion. ratio between length thermalization...
The dependence of X-ray excited luminescence intensity on BaF2 nanoparticle size was studied. A sharp decrease self-trapped exciton observed when the is less than 80 nm. main mechanism quenching caused by escape electrons from nanoparticles. Escape nanoparticles confirmed considerable increase polystyrene scintillator with embedded comparing pure scintillator.
The luminescence properties of CaF2 nanoparticles with various sizes (20–140 nm) are studied upon the excitation by VUV and x-ray quanta in order to reveal influence ratio mean free path thermalization length charge carriers nanoparticle size on self-trapped exciton luminescence. intensity for exciting quantum energies corresponding optical creation range electronic multiplication is not so sensitive as energy Eg < hν 2Eg. dependences at discussed terms electron-phonon...
Development of biocompatible multifunctional polymeric drug carriers is crucial in modern pharmaceutics aimed to create "smart" drugs. The high potential the PEGylated comb-like nanocarrier (PNC) delivering both traditional and experimental drugs tumor cells vitro vivo has been demonstrated previously. In present study, we investigated general toxicity polyethylene glycol (PEG) processed with covalent non-covalent attachments PEG compose a polymer that behaves like simple chain n monomers...
Severe toxic side effects and drug resistance are the major limitations of doxorubicin (Dox), one most potent anticancer agents in clinical use. Nanocarrier preparations offer opportunity to overcome these drawbacks, which is reflected approval two liposomal Dox preparations. Additionally, there many attempts enhance activity against multi-drug resistant (MDR) cancer cells. However, strategies resulted increased uptake cells, only, while it remained unchanged chemo-sensitive Here, we present...
Molybdenum disulphide (MoS2) is a layered material with interesting photocatalytic properties. In this study, MoS2 was produced using hydrothermal method. The obtained characterised by XRD (X-ray diffraction), XPS photoelectron spectroscopy), SEM (scanning electron microscopy), UV-Vis spectroscopy, DLS (dynamic light scattering), and zeta potential analysis. For the evaluation of properties MoS2, solution bromophenol blue (BPB) catalyst illuminated for 120 minutes. According to experimental...
Novel comb-like polymeric and oligomeric drug carriers combining backbone -copolymers of 5-tertbutylperoxy-5-methyl-1-hexene-3-yne (VEP) glycidyl methacrylate (GMA) -and side PEG chains various lengths were synthesized.Nanosized delivery systems containing conjugates water soluble anticancer Doxorubicin developed.The structures copolymers their with drugs confirmed by IR-spectroscopy.Structural colloidalchemical properties studied using photoluminescent (PL), UV-spectroscopy techniques,...
The genetic transformation of target cells is a key tool in modern biological research, as well many gene therapy and biotechnology applications. Here we describe new method for delivery DNA into several industrially important species yeast, including Saccharomyces cerevisiae. Our based on the use novel nanoscale oligoelectrolyte polymer possessing comb-like structure carrier molecule. Direct comparisons to standard methods clearly show that our approach: (i) yields two times more...
Novel heterotelechelic poly(N-vinylpyrrolidone) (CPA-PVP-IBMB) oligoperoxide containing anchoring carboxyl group from 4-cyanopentanoic acid (CPA) and peroxide end-group 1-isopropyl-3(4)-[1-(tert-butyl peroxy)-1-methylethyl]benzene (IBMB) chain transfer agent was synthesized investigated as a surface-active macroinitiator for tailored functionalization of maghemite (γ-Fe2O3) nanoparticles. CPA-PVP-IBMB initiated polymerization 2-hydroxyethyl methacrylate (HEMA) in ethanol yielding...
The aim of this study was to compare the effect new synthetic 4-thiazolidinone derivatives (potential anticancer compounds denoted as 3882, 3288 and 3833) doxorubicin (positive control) in free form their complexes with polyethylene glycol-containing nanoscale polymeric carrier on biochemical indicators nephrotoxicity blood serum rats. concentration total protein, urea, creatinine, glucose, ions sodium, potassium, calcium, iron chloride measured. It found that after injection investigated...
The controlled delivery of anticancer drugs is driven by their interaction with carrier molecules. By creating complicated micelle-like complexes, amphiphilic polymers provide an opportunity to load various kinds. In this work, the comb-like PEG-containing polymer poly(VEP-co-GMA)-graft-PEG water-soluble antitumor antibiotic doxorubicin and new water-insoluble derivatives thiozalidinone Les-3883 characterized a high efficiency has been studied in aqueous solutions means SAXS, DLS, TEM,...