A5090423019- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- interferon and immune responses
- DNA Repair Mechanisms
- CAR-T cell therapy research
King's College London
2023
University of Glasgow
2021-2022
Cancer Research UK Scotland Institute
2021-2022
Cancer Research UK
2022
Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer poorly understood. We find that mitochondrial promotes DNA damage under conditions of increased apoptotic priming. Underlying this process, we reveal a key role for dynamics in the regulation and genome instability. The ability to regulate oncogenic centers upon control minority outer membrane permeabilization (MOMP), process enables non-lethal caspase activation leading damage....
Abstract Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to lack of effective treatment options leading persistence or recurrence. We investigated therapeutic potential targeting anti-apoptotic BCL-2 proteins GBM. Levels BCL-xL and MCL-1 were consistently increased compared with non-malignant cells tissue. Moreover, we found that relative their differentiated counterparts, patient-derived stem-like also...
Coxsackievirus and adenovirus receptor (CAR) is a transmembrane cell–cell adhesion that forms homodimers across junctions plays key role in mediating epithelial barrier integrity. CAR can also heterodimerise with receptors on the surface of leukocytes thus an additional immune cell transmigration tissues. Given importance both biological processes cancer, emerging as potential mediator tumorigenesis well target cancer cells for viral therapy delivery. However, emerging, often conflicting,...
Abstract IDH wild-type glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to lack of effective treatment options leading persistence or recurrence. Tackling this, we investigated therapeutic potential targeting anti-apoptotic BCL-2 proteins GBM. Levels anti- apoptotic BCL-xL and MCL-1 were consistently increased compared with non- cells tissue. Moreover, found that relative their differentiated counterparts,...
Summary Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer poorly understood. We find that mitochondrial promotes DNA damage under conditions of increased apoptotic priming. Underlying this process, we reveal a key role for dynamics in the regulation and genome instability. The ability to regulate oncogenic centres upon control minority MOMP, process enables non-lethal caspase activation leading damage. fusion suppresses its...
Lung cancer is one of the most common cancers worldwide, and despite improvements in treatment regimens, patient prognosis remains poor. adenocarcinomas develop from lung epithelia understanding how specific genetic environmental factors lead to oncogenic transformation these cells great importance define pathways that contribute tumorigenesis. The recent rise use immunotherapy treat different has prompted exploration immune modulators tumour may provide new targets manipulate this process....