A5016126501- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Cell death mechanisms and regulation
- Renal and related cancers
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Malaria Research and Control
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- RNA Interference and Gene Delivery
- interferon and immune responses
- RNA modifications and cancer
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
Cancer Research UK
2024
University of Glasgow
2022-2024
Cancer Research UK Scotland Institute
2022
Center for Research and Advanced Studies of the National Polytechnic Institute
2017-2021
Instituto Politécnico Nacional
2020-2021
Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer poorly understood. We find that mitochondrial promotes DNA damage under conditions of increased apoptotic priming. Underlying this process, we reveal a key role for dynamics in the regulation and genome instability. The ability to regulate oncogenic centers upon control minority outer membrane permeabilization (MOMP), process enables non-lethal caspase activation leading damage....
Abstract Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown be inherently pro-inflammatory with emerging cellular roles, including its ability elicit anti-tumour immunity. Nonetheless, how triggers inflammation the regulates this remains poorly defined. We find upon MOMP, many proteins localised either inner or mitochondrial membranes are...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable and devastating malignant tumors. Epigenetic modifications such as DNA methylation histone modification regulate tumor initiation progression. However, contribution variants in PDAC unknown. Here, we demonstrated that variant H2A.Z highly expressed cell lines patients its overexpression correlates with poor prognosis. Moreover, all three isoforms (H2A.Z.1, H2A.Z.2.1, H2A.Z.2.2) are patients. Knockdown these induces a...
Abstract A single layer of polarized epithelial cells lining the colonic mucosa create a semipermeable barrier indispensable for gut homeostasis. The role intestinal cell (IEC) polarization in maintenance homeostasis and development inflammatory bowel diseases is not fully understood. In this review, now we report that IEC plays an essential regulation IL-6/STAT3 signaling mucosa. Our results demonstrate autocrine STAT3 activation IECs mediated by apical secretion IL-6 response to...
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, has quickly spread in many regions around the world where dengue (DENV) is endemic. This represents a major health concern, given high homology between these two viruses, which can result cross-reactivity. The aim of this study was to determine cross-reacting antibody response IgM and IgG classes against recombinant envelope protein ZIKV (rE-ZIKV) sera from patients with acute-phase infection different clinical forms dengue, i.e.,...
Dengue virus infection (DENV-2) is transmitted by infected mosquitoes via the skin, where many dermal and epidermal cells are potentially susceptible to infection. Most of in an area will establish antiviral microenvironment control viral replication. Although cumulative studies report permissive DENV-2 dendritic cells, keratinocytes, fibroblasts, among other also infected, little information available regarding cell-to-cell crosstalk effect this on outcome Therefore, our study focused...