A5077634404- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- Insect behavior and control techniques
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Genetic diversity and population structure
- Pluripotent Stem Cells Research
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Renal and related cancers
- Cancer-related gene regulation
- Neurobiology and Insect Physiology Research
Universidad Nacional Autónoma de México
2020-2025
Abstract Master hematopoietic transcription factors (TFs) and long noncoding RNAs (lncRNAs) coordinate shaping lineage-specific gene expression programs during differentiation. The architectural protein CCCTC-binding factor (CTCF) has emerged as a pivotal regulator of in cell However, the relationship its regulatory effect CTCF on lncRNA genes hematopoiesis remain elusive. We demonstrated that constrains DUBRtranscription throughout erythroid DUBR is highly expressed human stem progenitor...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable and devastating malignant tumors. Epigenetic modifications such as DNA methylation histone modification regulate tumor initiation progression. However, contribution variants in PDAC unknown. Here, we demonstrated that variant H2A.Z highly expressed cell lines patients its overexpression correlates with poor prognosis. Moreover, all three isoforms (H2A.Z.1, H2A.Z.2.1, H2A.Z.2.2) are patients. Knockdown these induces a...
Breast Cancer (BC) was the most common female cancer in incidence and mortality worldwide 2020. Similarly, BC top USA 2022. Risk factors include earlier age at menarche, oral contraceptive use, hormone replacement therapy, high body mass index, mutations BRCA1/2 genes, among others. is classified into Luminal A, B, HER2-like, Basal-like subtypes. These subtypes present differences gene expression signatures, which can impact clinical behavior, treatment response, aggressiveness, metastasis,...
Recent evidence suggests that human gene promoters display expression regulatory mechanisms beyond the typical single local transcription modulation. In mammalian genomes, genes with an associated bidirectional promoter are abundant; architecture serves as a hub for pair expression. However, it has been suggested its contribution to transcriptional regulation might exceed initiation Despite their abundance, functional consequences of remain largely unexplored. This work studies long-range...
-regulatory elements (CREs) play crucial roles in regulating gene expression during erythroid cell differentiation. Genome-wide erythroid-specific CREs have not been characterized chicken cells, which is an organism model used to study epigenetic regulation erythropoiesis.