A5073751028- Electrocatalysts for Energy Conversion
- Catalytic Processes in Materials Science
- Fuel Cells and Related Materials
- Catalysis and Oxidation Reactions
- Advanced battery technologies research
- Catalysis and Hydrodesulfurization Studies
- GaN-based semiconductor devices and materials
- Electrochemical Analysis and Applications
- Catalytic Cross-Coupling Reactions
- Advanced Materials Characterization Techniques
- Statistical Methods in Clinical Trials
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Nanomaterials for catalytic reactions
- Crystallization and Solubility Studies
- Statistical Methods and Inference
- Organoboron and organosilicon chemistry
- Zeolite Catalysis and Synthesis
- FOXO transcription factor regulation
- Advanced Causal Inference Techniques
- Catalysts for Methane Reforming
- Conducting polymers and applications
- Ga2O3 and related materials
- Metal and Thin Film Mechanics
- Acoustic Wave Resonator Technologies
Ford Motor Company (United States)
2019-2023
Taiwan Semiconductor Manufacturing Company (Taiwan)
2023
Boston College
2021-2023
The Barbara Ann Karmanos Cancer Institute
2022
Wayne State University
2022
Purdue University West Lafayette
2022
University of California, Berkeley
2013-2020
Michigan United
2020
University of Waterloo
2011-2014
Cedars-Sinai Medical Center
2014
Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters and dietary amines. Despite the association between MAOA PCa, it is unclear how promotes PCa progression. Here, we found functions to induce epithelial-to-mesenchymal transition (EMT) stabilize transcription factor HIF1α, which mediates hypoxia through an elevation ROS, thus enhancing growth, invasiveness,...
Fe-based oxygen reduction reaction (ORR) catalyst materials are considered promising nonprecious alternatives to traditional platinum-based catalysts. These generally produced by high-temperature pyrolysis treatments of readily available carbon, nitrogen, and iron sources. Adequate control the structure active site formation during methods is nearly impossible. Thus, chemical nature, structure, ORR mechanism catalytically sites in these a subject significant debate. We have proposed method,...
Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development functions. Abnormal MAO activity has been implicated several neuropsychiatric disorders, depression, autism, attention deficit hyperactivity disorder, which show sexual dimorphism. However, molecular basis for these disease processes is unclear. Recently, we found that was putative target gene...
Titanium nitride–carbon nanotube (TiN–CNT) core–shell nanocomposites were developed by a simplistic two step fabrication procedure and characterized transmission electron microscopy, X-ray diffraction thermogravimetric analysis. These materials utilized as platinum nanoparticle electrocatalyst supports (Pt/TiN–CNT) for the oxygen reduction reaction (ORR) methanol oxidation (MOR), important low temperature fuel cell processes. Improved ORR MOR activities demonstrated Pt/TiN–CNTs compared with...
The Fisher randomization test (FRT) is appropriate for any statistic, under a sharp null hypothesis that can recover all missing potential outcomes. However, it often sought after to weak the treatment does not affect units on average. To use FRT hypothesis, we must address two issues. First, need impute outcomes although cannot determine of them. Second, choose proper statistic. For general propose an approach imputing compatible hypothesis. Building this imputation scheme, advocate...
In this work, we develop a simple method to thermally synthesize nonprecious metal-based nitrogen-doped graphene (NG) electrocatalyst using exfoliated (Ex-G) and urea with varying amounts of iron (Fe) precursor. The morphology structural features the synthesized (Fe-NG) were characterized by SEM TEM, revealing existence graphitic nanoshells that potentially contribute ORR activity providing higher degree edge plane exposure. surface elemental composition catalyst was analyzed through XPS,...
Development of low cost active catalysts toward oxygen reduction reaction (ORR) is critical for the effective operation Li–O2 battery. Porous nonprecious iron–carbon based nanofiber have been developed by electrospinning method. The demonstrated similar ORR catalytic activity as commercial Pt-based in aqueous half-cell voltammetry sweeps. In aprotic environment, catalyst exhibited higher on-set potentials when compared to glassy carbon and Pt disk electrodes. results show that electrospun...
Background Vitamin D binding protein-macrophage activating factor (DBP-maf) is a potent inhibitor of tumor growth. Its activity, however, has been attributed to indirect mechanisms such as boosting the immune response by macrophages and inhibiting blood vessel growth necessary for tumors. Methods Findings In this study we show first time that DBP-maf exhibits direct effect on prostate cells in absence macrophages. demonstrated inhibitory activity proliferation studies both LNCaP PC3 cancer...
Ethylene diamine-based nitrogen doped carbon nanotube (NCNT) was successfully synthesized on thermally reduced graphene oxide (TRGO) by an injection chemical vapor deposition method and its electrocatalytic activities for oxygen reduction evolution reactions (ORR OER, respectively) were investigated metal air battery applications. The TRGO/NCNT composite with a novel bridged planes morphology does not only exhibits ORR performance similar to that of commercial Pt/C catalyst, but also...
A cooperative catalyst system involving a Pd(0)/Senphos complex, tris(pentafluorophenyl)borane, copper bromide, and an amine base, is demonstrated to catalyze trans-hydroalkynylation of internal 1,3-enynes. For the first time, Lewis acid shown promote reaction emerging outer-sphere oxidative step. The resulting cross-conjugated dieneynes are versatile synthons for organic synthesis, their characterization reveals distinct photophysical properties depending on positioning donor/acceptor...
Abstract A new family of carbon‐bound boron enolates, generated by a kinetically controlled halogen exchange between chlorocatecholborane and silylketene acetals, is described. These C−boron enolates are demonstrated to activate 1,3‐enyne substrates in the presence Pd 0 /Senphos ligand complex, resulting first examples carboboration reaction an alkyne with enolate‐equivalent nucleophiles. Highly substituted dienyl building blocks produced excellent site‐, regio‐, diastereoselectivity...
To improve the performance of three-way catalysts (TWC), it is essential to further develop our understanding microstructure–performance relationships in next-generation TWC. Light-off measurement combined with comprehensive structural imaging using advanced characterization techniques reveals correlation between catalyst activity and atomic-scale morphology deactivated regenerated Rh/Al2O3 catalysts. Using scanning transmission electron microscopy (STEM), energy-loss spectroscopy (EELS),...
Pyrolyzed Fe/N/C catalysts were synthesized using a newly designed and 2,3,7,8-tetra(pyridin-2-yl)pyrazino[2,3-g]quinoxaline (TPPQ) organic compound as the nitrogen-containing ligand. The structure of TPPQ was deliberately to discourage agglomeration Fe during heat treatment well provide concentrated source nitrogen. Catalysts prepared by first coordinating with Fe, forming Fe–TPPQ complexes, followed impregnation onto carbon black (KJ600) pyrolysis at 900 °C. 0.5%, 1%, 2%, 4%, 8% initial...
Glucocorticoid steroid hormones play important roles in many neurophysiological processes such as responses to stress, behavioral adaption, and mood. One mechanism by which glucocorticoids exert functions the brain is via modulation of neurotransmission systems. Glucocorticoids are capable inducing activities monoamine oxidases (MAOs), degrade neurotransmitters including serotonin, norepinephrine, phenylethylamine, dopamine. However, molecular mechanisms for induction not yet fully...