A5064320053- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA regulation and disease
- Nuclear Structure and Function
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cystic Fibrosis Research Advances
- Protein Hydrolysis and Bioactive Peptides
- Circadian rhythm and melatonin
- Heavy Metals in Plants
- Dendrimers and Hyperbranched Polymers
- Hepatitis C virus research
- Bioinformatics and Genomic Networks
- Meat and Animal Product Quality
- Computational Drug Discovery Methods
- Muscle metabolism and nutrition
- Renal and related cancers
Georgia Institute of Technology
2020-2025
China Pharmaceutical University
2018-2025
Taipei Medical University
2024
Institute of Molecular Biology, Academia Sinica
2024
Second Affiliated Hospital of Fujian Medical University
2021-2024
Fujian Medical University
2021-2024
Wenzhou Medical University
2018-2024
First Affiliated Hospital of Wenzhou Medical University
2018-2024
The Second Affiliated Hospital of Xiamen Medical College
2017-2024
State Key Laboratory of Natural Medicine
2018-2024
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, provided safe and efficient delivery available. In particular, specific to target cells critical achieving high efficacy while reducing toxicity. Amphiphilic dendrimers are promising carriers siRNA by virtue of the combined multivalent cooperativity with self-assembling property lipid vectors. Here, we report ballistic approach targeted cancer using an amphiphilic dendrimer equipped dual targeting...
Duplication of the gene encoding lamin B1 (LMNB1) with increased mRNA and protein levels has been shown to cause severe myelin loss in brains adult-onset autosomal dominant leukodystrophy patients. Similar many neurodegenerative disorders, patients are phenotypically normal until adulthood defect is specific central nervous system despite ubiquitous expression pattern B1. We set out dissect molecular mechanisms underlying this demyelinating phenotype. Increased results disturbances inner...
Significance Understanding molecular mechanisms that underlie the processes for myelin synthesis and maintenance has been an intensely investigated topic. Concurrently, recent advances in noncoding RNAs (ncRNAs) have uncovered unique insights into many biological processes, ncRNAs become recognized as major players epigenetic regulation. We generated a murine model overexpressing microRNA-23a ( miR-23a ) to investigate its role In addition, we used this mouse identify two targets of : one is...
Adult-onset autosomal-dominant leukodystrophy (ADLD) is a progressive and fatal neurological disorder characterized by early autonomic dysfunction, cognitive impairment, pyramidal tract cerebellar white matter loss in the central nervous system. ADLD caused duplication of LMNB1 gene, which results increased lamin B1 transcripts protein expression. How leads to myelin defects unknown. To address this question, we developed mouse model that overexpresses B1. These mice exhibited impairment...
Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strategy targeting ovarian involving a nanoformulation (Bola/IM)─bola-amphiphilic dendrimer (Bola)-encapsulated imatinib (IM)─to target critical mediator stem cells (CSCs) CD117 (c-Kit). Bola/IM offered significantly more CSCs compared to IM alone, through novel...
Abstract The interaction relationship between miRNAs and genes is important as play a crucial role in regulating gene expression. In the literature, several databases have been constructed to curate known miRNA target genes, which are valuable resources but likely only represent small fraction of all miRNA-gene interactions. this study, we machine learning models predict that not previously reported. Using expression data from TCGA, performed correlation analysis across multiple cancer...
Significance Although most known Mendelian genes causing nonsymptomatic epilepsies encode ion channels, Mass1 (monogenic audiogenic seizure susceptible 1) is among the few epilepsy that do not suggesting membrane hyperexcitability can arise indirectly. Here we found MASS1 protein highly expressed in colliculi of adult brain, where senses extracellular calcium and activates PKA PKC signaling via Gαs Gαq to regulate stability MAG myelin-forming cells. These data provide us with a unique...
gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter of CNS, and GABA transporter 1 (GAT-1) critical in maintaining a reservoir associated functions. The wide expression GAT-1 CNS prompted us to explore its role neuroimmunological disorders. In mice induced with experimental autoimmune encephalomyelitis (EAE), animal model multiple sclerosis, we found that levels mRNA protein spinal cord were greatly suppressed as compared those naive irrelevant Ag-immunized mice....
Adult-onset autosomal dominant leukodystrophy (ADLD) is a progressive and fatal hereditary demyelination disorder characterized initially by autonomic dysfunction loss of myelin in the central nervous system (CNS). Majority ADLD caused genomic duplication nuclear lamin B1 gene (LMNB1) encoding protein, resulting increased dosage brain tissue. In vitro, excessive at cellular level reduces transcription genes, leading to premature arrest oligodendrocyte differentiation. Murine models...
Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks feedback loops fine-tune circadian processes. Our knowledge these pathways is far from exhaustive. In recent decades, nuclear envelope has emerged a global gene regulatory machine, although its role in regulation not been explored. We report transcription core clock component BMAL1 positively...
Temporally restricted feeding (RF) can phase reset the circadian clocks in numerous tissues mammals, contributing to altered timing of behavioral and physiological rhythms. However, little is known regarding underlying molecular mechanism. Here we demonstrate a role for gamma isotype protein kinase C (PKCγ) food-mediated entrainment behavior clock. We found that daytime RF reduced late-night activity wild-type mice but not homozygous null mutation PKCγ (PKCγ(-/-)). Molecular analysis...
Aquaporin-2 (AQP2) is a molecular water channel protein responsible for reabsorption by the kidney collecting ducts. Many balance disorders are associated with defects in AQP2 gene expression regulated peptide hormone vasopressin. Here, we studied roles of Elf3 (E26 transformation-specific (Ets)-related transcription factor 3) duct cells (mpkCCD). Vasopressin increased mRNA and levels without affecting degradation, indicative transcriptional regulation. knockdown overexpression,...
Objective: Previous studies have shown that oyster peptides (OPs) antioxidant and anti-fatigue activities. This study aimed to investigate the effects of OPs on swimming endurance in mice underlying mechanisms.
Abstract Colorectal cancer (CRC) is highly heterogeneous leading to variable prognosis and treatment responses. Therefore, it necessary explore novel personalized reproducible prognostic signatures aid clinical decision‐making. The present study combined large‐scale gene expression profiles data of 1828 patients with CRC from multi‐centre studies identified a signature consisting 46 unique genes (called function‐derived [FunPGS]) an integrated statistics perspective. In the meta‐training...
Due to new energy electric vehicle market developing rapidly, a series of supply problems in the charging system urgently need be solved. The two subsystems this photovoltaic station are studied respectively. Firstly, topology equivalent circuit diagram three-level pulse width modulation rectifier is proposed. And simplified space vector algorithm applied control current inner loop and voltage outer AC/DC. A bidirectional DC/DC converter was introduced, its power characteristics...