A5079181980- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glutathione Transferases and Polymorphisms
- Radiomics and Machine Learning in Medical Imaging
- Ion channel regulation and function
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Immune cells in cancer
Anhui Medical University
2020-2022
Second Hospital of Anhui Medical University
2020
Abstract Resistance to chemotherapy remains a major obstacle the successful treatment of breast cancer. More than 80% patients who receive neoadjuvant (NAC) do not achieve pathologic complete response. In this study, we report novel p62 mRNA isoform with short 3′-UTR (untranslated region; p62-SU, 662-nt) that is associated chemoresistance in cancer cells and tissue specimens. The was identified by RNA sequencing qRT-PCR, 3′-RACE, Northern blot analysis. vitro vivo, ectopic expression p62-SU...
NUDT21, an RNA binding protein, has been reported to play important role in the regulation of multiple biological responses. Detection NUDT21 expression may lead identification a novel marker for breast cancer.The aim this study was investigate clinical significance and functional protein examined by immunohistochemistry (IHC) 100 paraffin-embedded, archived cancer samples benign tissues. Then, correlations between clinicopathologic characteristics prognoses patients were analyzed. In...
BACKGROUND: ARHGDIB, a Rho GDP dissociation inhibitor protein, has been reported playing critical roles in regulation of multiple biological responses. However, whether ARHGDIB serves as valuable biomarker cancer is little known so far, especially breast cancer. OBJECTIVE: In this study, we aimed to investigate the importance cancer, including but not limited biomarker-like role, well potential mechanisms. METHODS: Total 100 samples and benign disease were enrolled underwent detailed...
Abstract Background Non–small cell lung cancer (NSCLC) is a common malignant tumor with an increasing incidence. PIEZO-type mechanosensitive ion channel component 1 (PIEZO1) whose expression has been implicated in various cancers. However, its patterns, prognostic implications, and specific molecular mechanisms of action NSCLC remain unclear. This study aimed to characterize the profile PIEZO1 vitro using bioinformatics analyses. Methods To determine normal cancerous human tissues mRNA...
<div>Abstract<p>Resistance to chemotherapy remains a major obstacle the successful treatment of breast cancer. More than 80% patients who receive neoadjuvant (NAC) do not achieve pathologic complete response. In this study, we report novel p62 mRNA isoform with short 3′-UTR (untranslated region; p62-SU, 662-nt) that is associated chemoresistance in cancer cells and tissue specimens. The was identified by RNA sequencing qRT-PCR, 3′-RACE, Northern blot analysis. <i>In...
Supplementary Data from An Alternatively Spliced p62 Isoform Confers Resistance to Chemotherapy in Breast Cancer
Supplementary Data from An Alternatively Spliced p62 Isoform Confers Resistance to Chemotherapy in Breast Cancer
<div>Abstract<p>Resistance to chemotherapy remains a major obstacle the successful treatment of breast cancer. More than 80% patients who receive neoadjuvant (NAC) do not achieve pathologic complete response. In this study, we report novel p62 mRNA isoform with short 3′-UTR (untranslated region; p62-SU, 662-nt) that is associated chemoresistance in cancer cells and tissue specimens. The was identified by RNA sequencing qRT-PCR, 3′-RACE, Northern blot analysis. <i>In...