A5115601778- Microbial infections and disease research
- Virology and Viral Diseases
- vaccines and immunoinformatics approaches
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
- Animal Virus Infections Studies
- Ion channel regulation and function
Chinese Academy of Agricultural Sciences
2024-2025
Institute of Animal Sciences
2024
Pigeon Paramyxovirus Type 1 (PPMV-1), an antigenic and host variant of the Newcastle Disease Virus (NDV), can infect pigeons all ages cause severe economic losses in poultry industry. The existing commercial vaccines are not capable providing complete protection against prevalent PPMV-1 strains. To address this issue, reverse genetic technology was employed to create a recombinant 167DM strain by incorporating chimeric genotype Ⅵ hemagglutinin-neuraminidase (HN) with La Sota as backbone....
Background: Pigeon paramyxovirus type 1 (PPMV-1) is a significant pathogen affecting pigeon populations globally. The commonly used La Sota vaccine provides limited protection due to antigenic divergence from circulating PPMV-1 strains. An antigenically matched needed address this challenge. Methods: attenuated aTJ strain was developed through reverse genetics by modifying the F protein cleavage site of virulent TJ-WT strain. Pigeons were immunized twice with via eyedrop and intranasal...
Abstract Background Non–small cell lung cancer (NSCLC) is a common malignant tumor with an increasing incidence. PIEZO-type mechanosensitive ion channel component 1 (PIEZO1) whose expression has been implicated in various cancers. However, its patterns, prognostic implications, and specific molecular mechanisms of action NSCLC remain unclear. This study aimed to characterize the profile PIEZO1 vitro using bioinformatics analyses. Methods To determine normal cancerous human tissues mRNA...