A5025252025- Protein Structure and Dynamics
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Biochemical and Molecular Research
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Photosynthetic Processes and Mechanisms
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- thermodynamics and calorimetric analyses
- Mycobacterium research and diagnosis
- Lipid Membrane Structure and Behavior
- vaccines and immunoinformatics approaches
- Protein Interaction Studies and Fluorescence Analysis
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Neurological diseases and metabolism
- Sarcoidosis and Beryllium Toxicity Research
- DNA and Nucleic Acid Chemistry
- Advanced NMR Techniques and Applications
- Mining and Gasification Technologies
Moscow State University
2024
Kurchatov Institute
2017-2024
Lomonosov Moscow State University
2020-2024
A.V. Shubnikov Institute of Crystallography
2017-2023
Russian Academy of Sciences
2017-2023
Federal Scientific Research Centre Crystallography and Photonics
2017-2023
Institute of Mathematical Problems of Biology
2023
Institute of Bioorganic Chemistry
2019
Using the envelope glycoprotein B (gB) crystal structure and digital prediction algorithm, B- T-cell antigenic determinants (epitopes) of human herpesvirus 1 (HHV-1), also known as herpes simplex virus (HSV-1), were generated, method for their production in form recombinant proteins was proposed. First, surface topological domain (ectodomain or spike) gB with mapped epitopes analyzed, most stable immunogenic (due to enrichment B-and epitopes) subdomains selected modeling subunit vaccine...