A5036039546- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Surgical Simulation and Training
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
Kobe University
2015-2025
Kobe Institute Of Computing
2022
Nagoya University
2022
Kobe University Hospital
2021
Saiseikai Nakatsu Hospital
2017
Tumor associated macrophages (TAMs) are the most abundant cancer stromal cells educated by tumor microenvironment to acquire trophic functions facilitating angiogenesis, matrix breakdown and cell motility. have anti-inflammatory properties or "alternatively" activated (M2) phenotype expressing CD204 and/or CD163. To know role of TAMs in growth progression esophageal squamous carcinomas (ESCCs), we calculated intratumoral CD204, CD163 CD68 macrophage count (MϕC) CD34-positive microvessel...
Tumor-associated macrophages (TAMs) are known to be involved in the progression, angiogenesis, and motility of various cancers. We previously reported association between an increased number infiltrating TAMs with tumor progression poor prognosis esophageal squamous cell carcinomas (ESCCs). To study roles ESCC, we first exposed peripheral blood monocyte (PBMo)-derived from healthy volunteers conditioned media TE series human ESCC line (TECM) confirmed induction expression M2 macrophage...
// Masayoshi Hosono 1, 2 , Yu-Ichiro Koma 1 Nobuhisa Takase Naoki Urakawa Nobuhide Higashino Kazuki Suemune Himiko Kodaira Mari Nishio Manabu Shigeoka Yoshihiro Kakeji and Hiroshi Yokozaki Division of Pathology, Department Kobe University Graduate School Medicine, Chuo-ku, 650-0017, Japan Gastro-intestinal Surgery, Correspondence to: Yokozaki, email: hyoko@med.kobe-u.ac.jp Keywords: CXCL8; esophageal squamous cell carcinoma; tumor-associated macrophage; tumor progression; microenvironment...
Tumor-associated macrophages (TAMs) have important roles in the angiogenesis and tumor immunosuppression of various cancers, including esophageal squamous cell carcinomas (ESCCs). To elucidate TAMs ESCCs, we compared gene expression profiles between human peripheral blood monocyte-derived macrophage-like cells (Macrophage_Ls) Macrophage_Ls stimulated with conditioned medium TE series ESCC line (TECM) (TAM_Ls) using cDNA microarray analysis. Among highly expressed genes TAM_Ls, focused on...
Tumor-associated macrophages (TAMs) contribute to the progression and mortality of various malignancies. We reported that high numbers infiltrating TAMs were significantly associated with tumor poor prognosis in esophageal squamous cell carcinoma (ESCC). In our previous investigation TAMs' actions ESCC, we compared gene expression profiles between peripheral blood monocyte (PBMo)-derived TAM-like stimulated conditioned media ESCC lines. Among upregulated genes macrophages, focused on CC...
Abstract Tumor‐associated macrophages ( TAM s) are known to be involved in the progression of various human malignancies. We previously demonstrated that CD 204 was a useful marker for s contributing angiogenesis, progression, and prognosis esophageal squamous cell carcinoma ESCC ). also showed conditioned media lines induced expression THP ‐1 monocytic leukemia cells. Here, we performed cDNA microarray analysis between cells stimulated with TPA (macrophage [MΦ]‐like cells) treated without...
Summary The number of elderly patients with esophageal cancer has increased in recent years. use thoracoscopic esophagectomy also increased, and its minimal invasiveness is believed to contribute postoperative outcomes. However, the short- long-term outcomes remain unclear. This study aimed elucidate safety feasibility minimally invasive patients. retrospective included 207 who underwent radical for thoracic squamous cell carcinoma at Kobe University Hospital between 2005 2014. Patients were...
Abstract Background Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of postoperatively and enteral an FT on long-term prognosis Methods analysed 317 patients who underwent minimally invasive oesophagectomy at Kobe University Hospital Hyogo Cancer Center from 2010 2015. The patients’ body was evaluated 3 months postoperatively. They were organised into (n = 65)...
Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon unclear. cDNA microarray analysis indicates that expression chemokine (C-C motif) ligand 1 (CCL1) up-regulated peripheral blood monocyte–derived stimulated using conditioned media from ESCC cells (TAM-like macrophages). Here, we evaluated role CCL1 was...
The risk factors for delayed gastric emptying (DGE) following gastrectomy are unclear. This study aimed to investigate the DGE and severity of DGE. We retrospectively evaluated 412 patients who underwent cancer between 2011 2019. cases were classified into (n = 27) non-DGE 385) groups; group was further two subgroups based on nasogastric tube insertion as an indicator severity. For determining relationship resected stomach volume DGE, we calculated area each surgical specimen using ImageJ...
Objective Laparoscopic endoscopic cooperative surgery for duodenal tumors (D‐LECS) has been developed to prevent leakage by reinforcing the submucosal dissection site. However, there no prospective trial showing feasibility of D‐LECS. Herein, we conducted a single‐arm confirmatory evaluate safety D‐LECS non‐ampullary superficial neoplasms. Methods This single‐center analyzed patients with neoplasms who underwent The primary endpoint was incidence any postoperative occurring on wall within 1...
One of the primary treatment for resectable advanced esophageal squamous cell cancer (ESCC) is neoadjuvant chemotherapy (NAC) followed by minimally invasive esophagectomy (MIE). Because neutrophil-to-lymphocyte ratio (NLR) a widely reported prognostic factor in several cancers, we investigated whether preoperative NLR biomarker ESCC patients treated with NAC and MIE.In this study, 174 who underwent MIE from January 2010 to December 2015, including 121 received NAC. The cutoff value was...
Obesity, a known risk factor for various types of cancer, reduces the number and function cytotoxic immune cells in tumor microenvironment (TIME). However, impact obesity on CD4+ T remains unclear. Therefore, this study aimed to clarify TIME. A tumor-bearing obese mouse model was established by feeding with 45% high-fat diet (HFD), followed inoculation colon cancer cell line MC38. Tumor growth significantly accelerated compared that mice fed control diet. showed significant reduction an...