A5072276247- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Molecular Sensors and Ion Detection
- Metal complexes synthesis and properties
- Supramolecular Chemistry and Complexes
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Luminescence and Fluorescent Materials
- Magnetism in coordination complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Electrochemical Analysis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Synthesis and Reactivity of Heterocycles
- Conducting polymers and applications
- Chemical Synthesis and Analysis
- Chemical Thermodynamics and Molecular Structure
- Computational Drug Discovery Methods
- Crystallography and molecular interactions
- Graphene and Nanomaterials Applications
- Paraoxonase enzyme and polymorphisms
- Analytical Chemistry and Sensors
- Genetic Neurodegenerative Diseases
Universitat de València
2015-2024
Parc Científic de la Universitat de València
2015-2024
Institut des Sciences Moléculaires
2020
Instituto de Física Corpuscular
2017
Universidad de Cádiz
2008
University of Coimbra
2003-2005
Universidade Nova de Lisboa
2003-2005
Rede de Química e Tecnologia
2003-2005
The synthesis, protonation behavior, and Cu2+ Zn2+ coordination chemistry of the novel bibrachial aza lariat ether (naphthalen-1-ylmethyl)[2-(20-{2-[(naphthalen-1-ylmethyl)amino]ethyl}-3,6,9,17,20,23,29,30-octaazatricyclo[23.3.1.1*11,15*]triaconta-1(29),11(30),12,14,25,27-hexaen-6-yl)ethyl]amine (L) are discussed. macrocycle, which has two aminoethyl naphthyl moieties symmetrically appended to a 2:2 azapyridinophane structure, displays, in pH range 2−11, six steps that correspond secondary...
A new fluorescent macrocyclic structure (L1) bearing two naphthalene units at both ends of a cyclic polyaminic chain containing phenanthroline was investigated with potentiometric and fluorescence (steady-state time-resolved) techniques. The emission spectra show the simultaneous presence three bands: short wavelength band (naphthalene monomer), middle (phenanthroline emission), long-wavelength band. All bands were found to be dependent on protonation state unit (including structures)....
MnII complexes of scorpiand-type azamacrocycles constituted by a tretrazapyridinophane core appended with an ethylamino tail including 2- or 4-quinoline functionalities show very appealing in vitro SOD activity. The observed behaviour is related to structural and electrochemical parameters.
The acid−base and coordination properties of a family pseudopeptidic ligands with C2 symmetry derived from valine (4a−e) have been studied using variety techniques as model for metal in peptides proteins. Cu2+ cation has selected studies, although, comparison, some results Zn2+ are also presented. Good agreement obtained between the by potentiometric titrations, spectroscopic analysis, mass spectrometry (ESI) studies. These highlight potential use ESI MS characterizing nature complex species...
We report here the remarkable catalytic efficiency observed for two Pd(II) azamacrocyclic complexes supported on multiwalled carbon nanotubes (MWCNTs) toward oxygen reduction reactions. Beyond a main (>90%) 4e- process and an onset potential close to or better than those of commercial Pt electrodes, MWCNTs functionalization strategy, aimed at chemically defined Pd(II)-based centers, allowed half-cell exceed proton-exchange-membrane fuel-cell reference/target mass activity set by U.S....
Background The clinical use of purified SOD enzymes has strong limitations due to their large molecular size, high production cost and immunogenicity. These could be compensated by using instead synthetic mimetic compounds low weight. Background/Methodology We have recently reported that two compounds, the MnII complexes polyamines Pytren2Q Pytren4Q, displayed antioxidant activity in bacteria yeast. Since frequently molecules with properties or free-radical scavengers also anti-inflammatory...
The binding properties of HL1, HL2, and HL3 ligands toward Cu(II) Zn(II) ions, constituted by tetraaza-macrocyclic rings decorated with pyrimidine pendants, were investigated means potentiometric UV spectrophotometric measurements in aqueous solution, the objective using related HL-M(II) (HL = HL1-HL3; M Cu, Zn) complexes for preparation hybrid MWCNT-HL-M(II) materials based on multiwalled carbon nanotubes (MWCNTs), through an environmentally friendly noncovalent procedure. As shown crystal...
A new G-(H2L)-Pd heterogeneous catalyst has been prepared via a self-assembly process consisting in the spontaneous adsorption, water at room temperature, of macrocyclic H2L ligand on graphene (G) (G + = G-(H2L)), followed by decoration macrocycle with Pd2+ ions (G-(H2L) G-(H2L)-Pd) under same mild conditions. This supramolecular approach is sustainable (green) procedure that preserves special characteristics and furnishes an efficient for Cu-free Sonogashira cross coupling reaction between...
Two new fluorescent macrocyclic structures bearing two naphthalene (Np) units at both ends of a cyclic polyaminic chain were investigated with potentiometric, fluorescence (steady-state and time-resolved) laser flash photolysis techniques. The emission studies show the presence an excimer species whose formation depends on protonation state polyamine chains implying existence bending movement (occurring in ground first singlet excited state), which allows to approach interact. For comparison...
The synthesis of two new ligands constituted a tris(2-aminoethyl)amine moiety linked to the 2,6 positions pyridine spacer through methylene groups in which hanging arm is further functionalized with 2-pycolyl (L1) or 3-pycolyl (L2) group presented. protonation L1 and L2 formation Cu2+ complexes have been studied using potentiometric, NMR, X-ray, kinetic experiments. results provide information about relevance molecular movements chemistry this kind so-called scorpiand ligand. comparison...
Synthetic scorpiand-like azamacrocycles selectively inhibit SOD and TR enzymes of <italic>Trypanosoma cruzi</italic> in mice causing death the parasites increasing mouse survival rate after infection treatment.
Among the Krebs cycle components, just citrate enhances fluorescence of a new bi(brachial) lariat aza-crown containing appended naphthalene fluorophores.
The formation of Cu(II) complexes with two isomeric quinoline-containing scorpiand-type ligands has been studied. have a tetraazapyridinophane core appended an ethylamino tail including 2-quinoline (L1) or 4-quinoline (L2) functionalities. Potentiometric studies indicate the stable CuL(2+) species both ligands, L1 complex being 3-4 log units more than L2 complex. crystal structure [Cu(L1)](ClO(4))(2)·H(2)O shows that coordination geometry around Cu(2+) ions is distorted octahedral...
Aza-scorpiand-like macrocycles candidates for the development of affordable anti-leishmanicidal agents.
The synthesis of a polyazamacrocycle constituted by two diethylenetriamine bridges functionalized at their central nitrogen with naphth-2-ylmethyl units and interconnected through 2,6-dimethylpyridine spacers (L1) is reported. protonation behaviour the new macrocycle in water water-ethanol 70/30 v/v mixed solvent has been examined means pH-metric, UV-Vis steady-state fluorescence techniques. emission slightly quenched following deprotonation tertiary amines more deeply upon secondary amino...
A ligand (L1) (bis(aminoethyl)[2-(4-quinolylmethyl)aminoethyl]amine) containing a 4-quinolylmethyl group attached to one of the terminal amino groups tris(2-aminoethyl)amine (tren) has been prepared, and its protonation constants stability for formation Cu2+ complexes have determined. Kinetic studies on in slightly acidic solutions acid-promoted complex decomposition strongly suggest that Cu2+−L1 exists solution as mixture two species, them showing trigonal bipyramidal (tbp) coordination...
Solar radiation, specifically ultraviolet radiation (UVR), is one of the harmful external factors that affect integrity skin upon sun overexposure. Its detrimental effects include aging (photoaging), pigmentation disorders, and cancer. Upon UVR exposure, a cascade different cellular responses initiated, giving rise to inflammatory processes, oxidative stress, protein misfolding, DNA lesions, among other effects. Therefore, there growing need explore characterize new compounds for...