A review of chiral, nanoscale science and technology is presented, with the subject divided into two topics. The first discusses nanotechnology in service asymmetric synthesis, chiral separations, analysis. second topic concerns broader research realm, where molecular chirality plays a role properties materials, including devices, supramolecules, nanotubes, fullerenes, DNA nanotechnology.

Virtually all mesenchymal stem cell (MSC) studies assume that therapeutic effects accrue from local myocardial of engrafted MSCs. Because few intravenously administered MSCs engraft in the myocardium, have mainly utilized direct delivery. We adopted a different paradigm.To test whether reduce left ventricular (LV) dysfunction both post-acute infarction and ischemic cardiomyopathy these are caused, at least partly, by systemic anti-inflammatory activities.Mice underwent 45 minutes anterior...

DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed different experimental techniques provided evidence that pH or metal-driven molecular reorganizations these ligands regulate ability to interact calf thymus (ctDNA) an intercalative mode. Interestingly enough, serve increase decrease the biological activities compounds significantly.

The interaction of the open-chain polyamine N-(3-aminopropyl)-N′-[3-(anthrylmethyl)aminopropyl]ethane-1,2-diamine (L) with relevant anionic forms adenosine 5′-triphosphate (ATP), 5′-diphosphate (ADP) and 5′-monophosphate (AMP) is described. Unambiguous criteria for defining thermodynamic selectivity based on use effective stability constants are presented. L several other topologically similar polyammonium receptors ATP has been shown to occur through electrostatic π-stacking intermolecular...

In this work the absorption and fluorescence emission properties as well protonation sequence of three open chain polyamine ligands different dimensions bearing an anthracene unit were studied. The stability constants with Ni2+, Cu2+, Zn2+, Cd2+ have been determined in 0.15 mol·dm−3 NaCl at 298.1 ± 0.1 K. values both follow expected trends according to number nitrogen donors, chelate rings hydrophilic−hydrophobic balance. Chelation enhancement (CHEF) was observed for some complexes these...

The synthesis, protonation behavior, and Cu2+ Zn2+ coordination chemistry of the novel bibrachial aza lariat ether (naphthalen-1-ylmethyl)[2-(20-{2-[(naphthalen-1-ylmethyl)amino]ethyl}-3,6,9,17,20,23,29,30-octaazatricyclo[23.3.1.1*11,15*]triaconta-1(29),11(30),12,14,25,27-hexaen-6-yl)ethyl]amine (L) are discussed. macrocycle, which has two aminoethyl naphthyl moieties symmetrically appended to a 2:2 azapyridinophane structure, displays, in pH range 2−11, six steps that correspond secondary...

A comprehensive investigation on the energetics and dynamics of a new fluorescent sensor constituted by tripodal polyamine receptor containing three naphthalene fluorophores, compound L, is reported. The influence external factors such as solvent, hydrogen ion concentration, temperature in photophysics discussed. dependence monomer/excimer interconversion L revealed an average percentage relative sensitivity 4.5%/°C thus portending its use sensor. activation energy for excimer formation (E1...

A new fluorescent macrocyclic structure (L1) bearing two naphthalene units at both ends of a cyclic polyaminic chain containing phenanthroline was investigated with potentiometric and fluorescence (steady-state time-resolved) techniques. The emission spectra show the simultaneous presence three bands: short wavelength band (naphthalene monomer), middle (phenanthroline emission), long-wavelength band. All bands were found to be dependent on protonation state unit (including structures)....

Abstract The detection of nucleotides is crucial importance because they are the basic building blocks nucleic acids. Scorpiand‐based polyamine receptors functionalized with pyridine or anthracene units able to form stable complexes in water, based on coulombic, π–π stacking, and hydrogen‐bonding interactions. This behavior has been rationalized by means an exploration NMR spectroscopy DFT calculations. Binding constants were determined potentiometry. Fluorescence studies have revealed...

Abstract The interaction in aqueous solution of adenosine 5′‐triphosphate (ATP) with a series open‐chain polyamines linked at one or both ends to anthrylmethyl naphthylmethyl fragments was followed by potentiometric titration, 1 H‐, 13 C‐, and 31 P‐NMR spectroscopy, steady‐state fluorescence measurements. results revealed greater stabilities for the compounds containing anthracene moiety than those naphthalene moiety, N ‐substituted groups being close just unit. H‐NMR spectra showed that all...

A series of compounds made up by linking methylnaphthalene fragments at both ends different polyamine chains have shown to behave as pH-regulated molecular machines driven light and fluorescence emission studies proved the formation an excimer between two naphthalene units whose appearance, intensity decay times depend on pH value media.

The fluorescence emission of a naphthalene unit attached to polyamine chain is quenched by intramolecular electron transfer from the deprotonated amines excited fluorophore. Measurements respective quenching rate constants as function distance, reveal an exponential dependence with β = 0.45 Å-1. Identical measurements carried out in deuterated water have shown similar distance 0.49 Å-1 but average reduction absolute values ca. 1.2. chains seem constitute bridge through which can find route...

A new series of triphenylamine-based ligands with one (TPA1PY), two (TPA2PY) or three pendant aza-macrocycle(s) (TPA3PY) has been synthesised and studied by means pH-metric titrations, UV/Vis spectroscopy fluorescence experiments. The affinity these for G-quadruplex (G4) DNA the selectivity they show G4s over duplex were investigated Förster resonance energy transfer (FRET) melting assays, fluorimetric titrations circular dichroism spectroscopy. Interestingly, interactions bi- especially...

Two new fluorescent macrocyclic structures bearing two naphthalene (Np) units at both ends of a cyclic polyaminic chain were investigated with potentiometric, fluorescence (steady-state and time-resolved) laser flash photolysis techniques. The emission studies show the presence an excimer species whose formation depends on protonation state polyamine chains implying existence bending movement (occurring in ground first singlet excited state), which allows to approach interact. For comparison...

The synthesis and steady-state fluorescence studies on the interaction with AMPH, METH, MDMA, DA of two diazatetraester pyrazole crowns containing appended N-(9H-fluoren-9-yl) N-(naphth-2-ylmethyl) functions, in a water/ethanol 70:30 mixture at physiological pH, are described.

We present a set of donor radii for the rare-earth cations obtained from analysis structural data available in Cambridge Structural Database (CSD). Theoretical calculations using density functional theory (DFT) and wave function approaches (NEVPT2) demonstrate that Ln-donor distances can be broken down into contributions cation atom, with minimum electron (ρ) defines position (3,–1) critical points corresponding well Shannon's crystal (CR). Subsequent linear fits experimental bond all rare...

The synthesis and interaction of N,N',N'',N'''-tetramethyl-2,6,9,13-tetraaza[14]paracyclophanes (B323Me(4)) with nucleotides inorganic phosphates is described. An easy methodology used to define thermodynamic selectivity. B323Me4 ATP has been monitored by (1)H, (31)P NMR molecular mechanics, ruling out the possibility participation pi-stacking interactions. Results show that N-methylation accompanied a strong increase in resulting macrocycle ATP.

The affinities of polyamines consisting ethylenediamine units equipped with either one or two terminal naphthyl-, anthryl-, acridyl towards PolyA.PolyU as an RNA model, and Poly(dA).Poly(dT) a DNA model are screened by measuring the melting point changes (ΔTm) double strands, also partially fluorimetric binding assay using ethidium bromide. larger aromatic moieties long spacers between them allow bisintercalation; this leads to increased preference for in comparison RNA, where ion pairing...

Aza-scorpiand-like macrocycles candidates for the development of affordable anti-leishmanicidal agents.

The synthesis of a polyazamacrocycle constituted by two diethylenetriamine bridges functionalized at their central nitrogen with naphth-2-ylmethyl units and interconnected through 2,6-dimethylpyridine spacers (L1) is reported. protonation behaviour the new macrocycle in water water-ethanol 70/30 v/v mixed solvent has been examined means pH-metric, UV-Vis steady-state fluorescence techniques. emission slightly quenched following deprotonation tertiary amines more deeply upon secondary amino...