A5056724230- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Heat shock proteins research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Connexins and lens biology
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Gene Regulatory Network Analysis
- Plant biochemistry and biosynthesis
- Microtubule and mitosis dynamics
- Plant Gene Expression Analysis
- Molecular Sensors and Ion Detection
- Peroxisome Proliferator-Activated Receptors
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Yersinia bacterium, plague, ectoparasites research
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
Universitat Pompeu Fabra
2017-2025
University of Lausanne
2022
Vall d'Hebron Institut de Recerca
2015
Universitat Autònoma de Barcelona
2014-2015
Institut d'Investigació Sanitària Pere Virgili
2012
Universitat Rovira i Virgili
2012
Connexin 43 (Cx43), the most widely expressed gap junction protein, is associated with a number of physiological and pathological conditions. Many functions Cx43 have been shown to be independent formation only require expression C-terminal fragments. Recent evidence demonstrated that naturally occurring isoforms can generated via internal translation.Here, we confirm domains Cx43, particularly major 20-kDa isoform, independently regulated by translation same single GJA1 gene transcript...
DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed different experimental techniques provided evidence that pH or metal-driven molecular reorganizations these ligands regulate ability to interact calf thymus (ctDNA) an intercalative mode. Interestingly enough, serve increase decrease the biological activities compounds significantly.
Oxidative stress is associated with cardiovascular and neurodegenerative diseases, diabetes, cancer, psychiatric disorders aging. In order to counteract, eliminate and/or adapt the sources of stress, cells possess elaborate stress-response mechanisms, which also operate at level regulating transcription. Interestingly, it becoming apparent that metabolic state cell certain metabolites can directly control epigenetic information gene expression. fission yeast Schizosaccharomyces pombe,...
Fission yeast is an excellent model system that has been widely used to study the mechanism control cell cycle progression. However, there a lack of tools allow measure with high precision duration different phases in individual cells. To circumvent this problem, we have developed fluorescent reporter allows quantification at single-cell level most genetic backgrounds. prove accuracy reporter, tested strains known delay G1/S or G2/M transitions, confirming strength and versatility system. An...
Cdc42 GTPase rules cell polarity and growth in fission yeast. It is negatively positively regulated by GTPase-activating proteins (GAPs) guanine nucleotide exchange factors (GEFs), respectively. Active Cdc42-GTP localizes to the poles, where it associates with numerous constituting module. However, little known about its downregulation. We describe here that oxidative stress causes Sty1-kinase-dependent inactivation at poles. Both amount of active tips length inversely correlate Sty1...
Compartmentalized regulation of RNAs is emerging as a key driver developmental transitions, with RNA-binding proteins performing specialized functions in different subcellular compartments. The protein Mei2, which arrests mitotic proliferation and drives zygotic development fission yeast, was shown to function the nucleus trigger meiotic divisions. Here, using compartment-restricted alleles, we report that Mei2 cytosol arrest growth initiate development. We find zygote-specific component...
ABSTRACT Oxidative stress is associated with cardiovascular and neurodegenerative diseases, diabetes, cancer, psychiatric disorders aging. In order to counteract, eliminate and/or adapt the sources of stress, cells possess elaborate stress-response mechanisms, which also operate at level regulating transcription. Interestingly, it becoming apparent that metabolic state cell certain metabolites can directly control epigenetic information gene expression. fission yeast Schizosaccharomyces...
ABSTRACT Cdc42 rules cell polarity and growth in fission yeast. It is negatively positively regulated by GTPase-activating proteins (GAPs) Guanine nucleotide Exchange factors (GEFs), respectively. Active Cdc42-GTP localizes to the poles, where it associates with numerous constituting module. However, little known about its down-regulation. We describe here that oxidative stress causes Sty1 kinase-dependent inactivation at poles. Both amount of active poles length inversely correlate...