A5041519458- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Heat shock proteins research
- COVID-19 Impact on Reproduction
- Sarcoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Developmental Biology and Gene Regulation
- Connexins and lens biology
- Comparative Literary Analysis and Criticism
- Medical History and Innovations
- Healthcare Systems and Technology
- Microtubule and mitosis dynamics
- Receptor Mechanisms and Signaling
- Fungal Plant Pathogen Control
- Radiopharmaceutical Chemistry and Applications
- Education in Rural Contexts
- Historical and Modern Theater Studies
- Marine Ecology and Invasive Species
Vall d'Hebron Hospital Universitari
2015-2024
Centro de Investigación Biomédica en Red de Cáncer
2017-2024
Universitat Autònoma de Barcelona
2014-2021
Vall d'Hebron Institut de Recerca
2010-2021
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2020
NYU Langone Health
2020
Pontificia Universidad Javeriana
2018
Fondazione Santa Lucia
2012
University of Rome Tor Vergata
2012
Centro de Investigación del Cáncer
2012
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% cancer-related deaths. The integrin ITGB3 has been previously described play an essential role in breast cancer metastasis, but precise mechanisms remain undefined. We have now uncovered and thus far unknown roles vesicle uptake. functional requirement for derives its interactions with heparan sulfate proteoglycans (HSPGs) process endocytosis, allowing capture extracellular vesicles their...
Connexin 43 (Cx43), the most widely expressed gap junction protein, is associated with a number of physiological and pathological conditions. Many functions Cx43 have been shown to be independent formation only require expression C-terminal fragments. Recent evidence demonstrated that naturally occurring isoforms can generated via internal translation.Here, we confirm domains Cx43, particularly major 20-kDa isoform, independently regulated by translation same single GJA1 gene transcript...
Background/Objectives: The clinical use of molecular biomarkers in thyroid cancer management requires standardized technical and analytical criteria, especially for gene fusion detection. Accurate identification patients suitable RET-selective inhibitors, a new treatment advanced cancer, depends on effective testing. This study aimed to validate alterations the RET assess diagnostic validity detection techniques through inter-institutional comparison. Methods: A two-site external...
Breast cancer is the most prevalent malignancy in women and there an urgent need for new therapeutic drugs targeting aggressive metastatic subtypes, such as hormone-refractory triple-negative breast (TNBC). Control of protein synthesis vital to cell growth tumour progression permits increased resistance therapy cellular stress. Hypoxic cells attain invasive properties chemotherapy resistance, but regulation role this setting poorly understood. We performed a polysomal RNA-Seq screen...
Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed association between phosphorylation cellular resistance to oxidative stress, starvation, DNA-damaging agents in vitro. Using immortalized cell lines, retroviral expression a phosphomimetic (S209D) form eIF4E, but not phospho-dead (S209A) or GFP control, significantly increased stress induced by (cisplatin), starvation...
PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and translation, whose overexpression associated a higher proliferation index tumor grade prostate cancer (PC) other neoplasms. Here we report its interaction the Notch pathway involvement PC progression. Stable knockdown or were performed by lentiviral transduction. Protein interactions analyzed co-immunoprecipitation, pull-down and/or immunofluorescence. Endogenous expression was real time RT-PCR...
The lipid raft protein Flotillin-1 was previously shown to be required for cell proliferation. Here we show that it is critical the maintenance of levels mitotic regulator Aurora B. Knockdown induced aberrant events similar those produced by B depletion and led a marked decline in activity. Transfection wild-type full-length or forms directed nucleus increased interacted with directly through its SPFH domain complex distinct from chromosomal passenger complex, two proteins co-purified...
Sarcomas characterized by
The VEGF family has been identified as abnormal in preeclampsia (PE). Hypertensive disorders of pregnancy (HDP) are major contributors to maternal and neonatal morbidity mortality worldwide; likewise, umbilical cord anatomical abnormalities (UCAA) linked poor outcomes. Based on the relationship described between PE UCAA role PE, this study explored expression placental UC tissued from patients with UCAA.We performed an observational, analytical placentas, comparing protein mRNA four groups:...
How cellular behaviors such as cell-to-cell communication, epithelial organization and cell shape reorganization are coordinated during development is poorly understood. The developing Drosophila eye offers an ideal model system to study these processes. Localized actin polymerization required constrict the apical surface of cells imaginal disc maintain refined arrangement ommatidia. identity each photoreceptor within epithelium determined by contacts involving signal transduction events. R7...
<h3>Introduction/Background</h3> Assessment of Homologous Recombination Deficiency (HRD) and BRCA mutational status in high-grade serous ovarian carcinoma (HGSOC) samples has become crucial for personalized medicine, guiding treatment decisions predicting response to specific therapies, such as PARP inhibitors. While Myriad MyChoice® CDx HRD (M-HRD) is a widely adopted clinically validated reference method, it's performed send-out test. We sought assess the reliability reproducibility SOPHIA...
Precision medicine has revolutionized the understanding and treatment of cancer by identifying subsets patients who are amenable to specific treatments according their molecular characteristics, as exemplified epidermal growth factor receptor (EGFR) mutations in non-small cell lung (NSCLC). Although tissue biopsy is gold standard for determining alterations tumors, its limitations have prompted development new techniques studying tumor biomarkers liquid biopsies, such mutation analysis...