A5041130759- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Invertebrate Immune Response Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Circadian rhythm and melatonin
- Protein Kinase Regulation and GTPase Signaling
- Plant Molecular Biology Research
- Animal Genetics and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Axon Guidance and Neuronal Signaling
- Insect Resistance and Genetics
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Microtubule and mitosis dynamics
- Advanced Proteomics Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Science Education and Pedagogy
- Insect Utilization and Effects
- RNA Research and Splicing
- Machine Learning in Bioinformatics
ETH Zurich
2013-2023
University of Zurich
2000-2019
Center for Pediatric Endocrinology Zurich
2011
Howard Hughes Medical Institute
1994-2008
Max Planck Society
2008
University College London
2004-2005
Cancer Research UK
2004-2005
The Honourable Society of Lincoln's Inn
2004-2005
Zürich Zoological Garden
1989-2005
University of Manchester
2003
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF regulates adult longevity. We found mutation of extends fruit fly median life-span by up to 48% homozygotes and 36% heterozygotes. Extension was not a result impaired oogenesis females, nor it consistently correlated with increased stress resistance. dwarf phenotype also unnecessary for...
Mammalian target of rapamycin (mTOR) is a central regulator protein synthesis whose activity modulated by variety signals. Energy depletion and hypoxia result in mTOR inhibition. While energy inhibits through process involving the activation AMP-activated kinase (AMPK) LKB1 subsequent phosphorylation TSC2, mechanism inhibition not known. Here we show that requires TSC1/TSC2 tumor suppressor complex hypoxia-inducible gene REDD1/RTP801 . Disruption loss TSC1 or TSC2 blocks effects on mTOR, as...
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the Drosophila insulin-like peptides, regulate hemolymph carbohydrate homeostasis during development are expressed a stage- tissue-specific manner. Here, we show that ablation peptide-producing median neurosecretory cells brain leads to increased fasting glucose...
Cell proliferation requires cell growth; that is, cells only divide after they reach a critical size. However, the mechanisms by which grow and maintain their appropriate size have remained elusive. Drosophila deficient in S6 kinase gene ( dS6K ) exhibited an extreme delay development severe reduction body These flies had smaller rather than fewer cells. The effect was cell-autonomous, displayed throughout larval development, distinct from of ribosomal protein mutants Minutes ). Thus,...
Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated timing effect reduced IIS on and role a potential target tissue, fat body. overexpressed dFOXO, downstream effector IIS, adult Drosophila body, which increased fecundity females but had no male life-span. The FOXO transcription factors adipose tissue are therefore evolutionarily conserved regulation aging, reduction is sufficient to mediate its effects...
Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response signaling insulin and insulin-like growth factor Caenorhabditis elegans mammals. In Drosophila, insulin-signaling pathway regulates size of cells, organs, entire body nutrient availability, controlling both cell number. this study, we present a genetic characterization dFOXO, only Drosophila ortholog. Ectopic expression dFOXO human FOXO3a induced organ-size reduction...
The adaptation of growth in response to nutritional changes is essential for the proper development all organisms. Here we describe identification Drosophila homolog target rapamycin (TOR), a candidate effector sensing. Genetic and biochemical analyses indicate that dTOR impinges on insulin signaling pathway by autonomously affecting through modulating activity dS6K. However, contrast other components pathway, partial loss function preferentially reduces endoreplicating tissues. These...
The determination of cell fates during the assembly ommatidia in compound eye Drosophila appears to be controlled by cell-cell interactions. In this process, sevenless gene is essential for development a single type photoreceptor cell. absence proper function cells that would normally become R7 photoreceptors instead nonneuronal cells. Previous morphological and genetic analysis has indicated product involved reading or interpreting positional information specifies particular developmental...
The ability to select a better option from multiple acceptable ones is important for animals optimize their resources. mechanisms that underlie such decision-making processes are not well understood. We found selection of egg-laying site in Drosophila melanogaster suitable system probe the neural circuit governs simple processes. First, females pursue active probing environment before depositing each egg, apparently evaluate quality every egg. Second, can either accept or reject...
Abstract We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. mobilized pair engineered P elements, p{RS3} and p{RS5}, to collect 3243 lines unambiguously mapped the genome sequence. The contains, on average, an element every 35 kb. demonstrate deletions their end points mapped, with base-pair resolution, was generated isogenic strain, thus affording uniform background screens where...