A5030447992- Hormonal and reproductive studies
- Pharmacology and Obesity Treatment
- Muscle metabolism and nutrition
- Sexual Differentiation and Disorders
- Pharmacological Effects and Assays
- Sexual function and dysfunction studies
- Hypothalamic control of reproductive hormones
- Pituitary Gland Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Sperm and Testicular Function
- Reproductive Health and Technologies
- Regulation of Appetite and Obesity
- Optical Network Technologies
- Chemokine receptors and signaling
- Thyroid Disorders and Treatments
- Doping in Sports
- Cardiovascular Effects of Exercise
- Neural Networks and Reservoir Computing
- Photonic and Optical Devices
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Diabetes Management and Research
Sci-Tech Daresbury
2025
Praevium Research (United States)
2025
University of Sheffield
2014-2024
Barnsley Hospital
2009-2024
Royal Hallamshire Hospital
1997-2023
Barnsley Hospital NHS Foundation Trust
2012-2022
Oxford Centre for Diabetes, Endocrinology and Metabolism
2018
University of Cincinnati Medical Center
2015
Taunton & Somerset NHS Foundation Trust
2014
National Health Service
2014
✓ An awake-primate model has been developed which permits reversible middle cerebral artery (MCA) occlusion during physiological monitoring. This method eliminates the ischemia-modifying effects of anesthesia, and correlation neurological function with blood flow (CBF) neuropathology. The was used to assess brain's tolerance focal ischemia. MCA occluded for 15 or 30 minutes, 2 3 hours, permanently. Serial monitoring evaluated function, local CBF (hydrogen clearance), other parameters (blood...
OBJECTIVE This study evaluated the effects of testosterone replacement therapy (TRT) on insulin resistance, cardiovascular risk factors, and symptoms in hypogonadal men with type 2 diabetes and/or metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS The efficacy, safety, tolerability a novel transdermal 2% gel was over 12 months 220 MetS multicenter, prospective, randomized, double-blind, placebo-controlled study. primary outcome mean change from baseline homeostasis model assessment...
OBJECTIVE—The aim of our study was to assess the prevalence clinical hypogonadism, based on both symptoms and biochemical available measures testosterone deficiency, in men with type 2 diabetes. RESEARCH DESIGN AND METHODS—In a cross-sectional 355 diabetic aged >30 years, total bioavailable testosterone, sex hormone–binding globulin, BMI, waist circumference were measured free calculated. Overt hypogonadism defined as presence low level (total <8 nmol/l and/or <2.5...
To examine the effect of serum testosterone levels on survival in a consecutive series men with confirmed coronary disease and calculate prevalence deficiency.Longitudinal follow-up study.Tertiary referral cardiothoracic centre. Patients 930 referred for diagnostic angiography recruited between June 2000 2002 followed up mean 6.9±2.1 years.All-cause mortality vascular mortality. Prevalence deficiency.The overall biochemical deficiency cohort using bio-available (bio-T) <2.6 nmol/l was 20.9%,...
Serum testosterone levels are known to inversely correlate with insulin sensitivity and obesity in men. Furthermore, there is evidence suggest that replacement therapy reduces resistance visceral adiposity type 2 diabetic Adipocytokines hormones secreted by adipose tissue contribute resistance. We examined the effects of treatment on various adipocytokines C-reactive protein (CRP) men.Double-blinded placebo-controlled crossover study 20 hypogonadal Patients were treated (sustanon 200 mg) or...
To evaluate the effects of testosterone-replacement therapy (TRT) on prostate health indicators in hypogonadal men, including rates cancer diagnoses, changes prostate-specific antigen (PSA) levels and lower urinary tract symptoms (LUTS) over time.The Registry Hypogonadism Men (RHYME) is a multi-national patient registry treated untreated, newly-diagnosed men (n = 999). Follow-up assessments were performed at 3-6, 12, 24, 36 months. Baseline follow-up data collection included medical history,...
Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis atherosclerosis. The testicular feminised mouse (non-functional androgen receptor low testosterone) develops fatty liver aortic lipid streaks on a high-fat diet, whereas androgen-replete XY littermate controls do not. treatment ameliorates these effects, although the underlying mechanisms remain unknown. We compared influence of testosterone...