A5033473414- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Urological Disorders and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Urinary and Genital Oncology Studies
- Ovarian function and disorders
- Sperm and Testicular Function
- Maternal and Perinatal Health Interventions
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Thermoregulation and physiological responses
- Molecular Biology Techniques and Applications
- Diet, Metabolism, and Disease
- Colorectal and Anal Carcinomas
- Global Cancer Incidence and Screening
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012-2021
Diakonessenhuis hospital
2016-2019
Vrije Universiteit Amsterdam
2019
Amsterdam University Medical Centers
2019
Zero to Three
2015
Recently, DNA methylation analysis of FAM19A4 in cervical scrapes has been shown to adequately detect high‐grade intraepithelial neoplasia and cancer (≥CIN3) high‐risk HPV (hrHPV)‐positive women. Here, we compared the clinical performance cytology HPV16/18 genotyping, separately combination, for ≥CIN3 detection hrHPV‐positive women participating a prospective observational multi‐center cohort study. The study population comprised aged 18–66 years, visiting gynecological outpatient clinic....
STUDY QUESTIONIs the presence of human papillomavirus (HPV) in semen associated with impairment quality?
High-risk human papillomavirus (hrHPV)-positive women require triage to identify those with cervical high-grade intraepithelial neoplasia and cancer (⩾CIN3 (cervical grade 3)). FAM19A4 methylation analysis, which detects advanced CIN cancer, is applicable different sample types. However, studies comparing the performance of analysis in hrHPV-positive self-samples paired physician-taken scrapes are lacking. We compared (and/or HPV16/18 genotyping) for ⩾CIN3 detection (n=450,18–66 years)....
Abstract Introduction In this study, we describe the distribution of placenta delivery and incidence postpartum hemorrhage in both spontaneous placental manual removal placenta. Methods A retrospective study was performed 7603 singleton vaginal deliveries a gestational age over 32 weeks, registered between September 2011 2016. We calculated (≥1000 mL blood loss) per 10‐minute duration third stage. The odds ratio for developing assessed, adjusted risk factors. compared women that did not...
Cervical screening by high-risk HPV (hrHPV) testing requires additional risk stratification (triage), as most infections are transient and only a subset of hrHPV-positive women harbours clinically relevant disease. Molecular triage markers such microRNAs (miRNAs) DNA methylation particularly promising, they can be objectively tested directly on scrapes cervicovaginal self-samples. Here, we evaluated the marker potential 10 candidate miRNAs in 209 with underlying precancer (cervical...