A5052748251- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Metabolism and Genetic Disorders
- Dementia and Cognitive Impairment Research
- Bipolar Disorder and Treatment
- Folate and B Vitamins Research
- Schizophrenia research and treatment
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Cardiac Health and Mental Health
- Substance Abuse Treatment and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Aging and Gerontology Research
- Amino Acid Enzymes and Metabolism
- Mental Health Treatment and Access
- Health and Well-being Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Alcoholism and Thiamine Deficiency
- Transcranial Magnetic Stimulation Studies
- Analytical Chemistry and Chromatography
- RNA modifications and cancer
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Parnassia Groep
2016-2025
White Plains Hospital
2024
Universidade de Santiago de Compostela
2023
University of Groningen
2009-2020
University Medical Center Groningen
2009-2020
Slotervaartziekenhuis
2018
Uitvoeringsinstituut Werknemersverzekeringen
2018
GGD Rotterdam-Rijnmond
2016-2017
University of Pittsburgh
2017
University of Amsterdam
1987-2016
To study late-life depression and its unfavourable course co morbidities in The Netherlands.We designed the Netherlands Study of Depression Older Persons (NESDO), a multi-site naturalistic prospective cohort which makes it possible to examine determinants, consequences depressive disorders older persons over period six years, compare these with those earlier adulthood.From 2007 until 2010, NESDO consortium has recruited 510 depressed non (≥ 60 years) at 5 locations throughout Netherlands....
Severe depression can be a life-threatening disorder, especially in elderly patients. A fast-acting treatment is crucial for this group. Electroconvulsive therapy (ECT) may work faster than medication.To compare the speed of remission using ECT v. medication in-patients.The in-patients with DSM-IV diagnosis major (baseline MADRS score ≥20) was compared between 47 participants (mean age 74.0 years, s.d. = 7.4) from an randomised controlled trial (RCT) and 81 72.2 7.6) RCT (nortriptyline...
We aimed to examine the course of depression during 2-year follow-up in a group clinically depressed older persons. Subsequently, we studied which socio-demographic and clinical characteristics predict diagnoses at follow-up.Data were used from Netherlands Study Depression Older persons (NESDO; N = 510). Diagnoses DSM-IV-TR criteria available 285 patients baseline follow-up. Severity depressive symptoms, as assessed with Inventory Depressive Symptoms (IDS), was obtained 6-monthly postal...
The relationship between peroxisomal and mitochondrial oxidation of the methyl branched fatty acids, phytanic acid pristanic acid, was studied in normal mutant human skin fibroblasts with established enzyme deficiencies. Tandem mass spectrometry used for analysis acylcarnitine intermediates. In cells, 4,8-dimethylnonanoylcarnitine (C11:0) 2,6-dimethylheptanoylcarnitine (C9:0) accumulated after incubation either or acid. These intermediates were not observed when peroxisome-deficient cells...
Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) late (LOD). It is not clear whether these two factors differentially affect the age first depression. Therefore, we wished to investigate relationship between volume, adjustment for lesions.MRI brain scans were used compare volumes matched female patients (>60 years) EOD LOD healthy controls.When comparing three groups adjusting age,...
Risk of neural tube defects (NTDs) is determined by genetic and environmental factors, among which folate status appears to play a key role. However, the precise nature link between low NTDs poorly understood, it remains unclear how folic acid prevents NTDs. We investigated effect level on risk in splotch (Sp(2)(H)) mice, carry mutation Pax3. Dietary restriction results reduced maternal blood folate, elevated plasma homocysteine embryonic content. Folate deficiency does not cause wild-type...
Abstract Clin Chem Lab Med 2007;45:903–11.
Depression later in life may have a more somatic presentation compared with depression earlier due to chronic disease and increasing age. This study examines the influence of presence diseases age on symptom dimensions late-life depression.Baseline data 429 depressed non-depressed older persons (aged 60-93 years) Netherlands Study Old Age were used, including dimension scores as assessed mood, motivation subscales Inventory Depressive Symptomatology-Self Report (IDS-SR). Linear regression...
Objective In the Netherlands, persons of Turkish, Moroccan and Surinamese descent form largest groups non‐western immigrants. A high prevalence mild cognitive impairment (MCI) dementia has been described in immigrant populations United States America Kingdom. We determined MCI older community‐dwelling adults from Netherlands. Methods Participants, aged 55 years older, (Arabic or Berber), (Creole Hindustani) Dutch were recruited via their general practitioners. Cognitive deficits assessed...
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits myelination and white matter integrity; however, direct etiological genetic cellular evidence has thus far been lacking. Here, we implement a family-based approach for discovery combined with functional analysis using induced pluripotent stem cells (iPSCs). We observed familial segregation two rare...
Article Abstract Objective: To compare the efficacy and cognitive side effects of high-dose unilateral brief pulse electroconvulsive therapy (ECT) with those ultrabrief ECT in treatment major depression. Method: From April 2007 until March 2011, we conducted a prospective, double-blind, randomized multicenter trial 3 tertiary psychiatric hospitals. All patients depressive disorder according to DSM-IV criteria were eligible. Depression severity was assessed Montgomery-Asberg Rating Scale;...
ABSTRACT Background: Late-life depression is a heterogeneous disorder, whereby cognitive impairments are often observed. This study examines which clinical characteristics and symptom dimensions of late-life especially impacting on specific domains. Methods: Cross-sectional data 378 depressed 132 non-depressed older adults between 60–93 years, from the Netherlands Study Depression in Older (NESDO) were used. Depressed recruited both inpatient outpatient mental healthcare institutes general...