A5113550899- Colorectal Cancer Treatments and Studies
- Biochemical and Molecular Research
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- Folate and B Vitamins Research
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Biopolymer Synthesis and Applications
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Sphingolipid Metabolism and Signaling
- Metabolism, Diabetes, and Cancer
University Medical Center Utrecht
2024
Utrecht University
2024
ERN GUARD-Heart
2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
1999-2008
Netherlands Comprehensive Cancer Organisation
2005
Vrije Universiteit Amsterdam
1993-2002
Novartis (Switzerland)
2001
University of Amsterdam
1991-1999
European Organisation for Research and Treatment of Cancer
1999
Norsk Hydro (Norway)
1999
PURPOSE To determine the time-dependence of fluorouracil (5FU)-induced thymidylate synthase (TS) inhibition in colon cancer patients, effect leucovorin (LV), and relation to response. PATIENTS AND METHODS A 5FU injection (500 mg/m2) was given 47 patients with advanced colorectal cancer; tumor biopsy specimens were obtained 1 72 hours after laparotomy. Eleven received LV (2-hour infusion 500 midinfusion; biopsies 45 hours. TS evaluated by comparing number total free...
Gemcitabine (2′,2′-difluorodeoxycytidine) is a deoxycytidine analogue that activated by kinase (dCK) to its monophosphate and subsequently triphosphate dFdCTP, which incorporated into both RNA DNA, leading DNA damage. Multidrug resistance (MDR) characterised an overexpression of the membrane efflux pumps P-glycoprotein (P-gP) or multidrug resistance-associated protein (MRP). was tested against human melanoma, non-small-cell lung cancer, small-cell epidermoid carcinoma ovarian cancer cells...
Abstract BACKGROUND Patients with advanced cervical carcinoma are treated routinely radiotherapy and cisplatin‐containing chemotherapy. It has been shown that hyperthermia can improve the results of both cisplatin. In current study, feasibility efficacy combination all three modalities was studied in previously untreated patients carcinoma. METHODS were registered prospectively U.S., Norway, Netherlands. External‐beam brachytherapy administered for a biologically effective dose ≥ 86.7 gray....
Cancer cell lines in standard culture medium or animal models are surrounded by an environment with relatively high folate (HF) levels, compared levels human plasma. In the present study we adapted 4 colon cancer (C26-A, C26-10, C26-G and WiDr) 3 squamous carcinoma of head neck (HNSCC) (11B, 14C 22B) to low (LF) (2.5, 1.0 0.5 nM, respectively) investigated whether depletion had effect on sensitivity antifolates which mechanisms were involved. All LF showed a higher 5-fluorouracil (5-FU)...