A5011197886- Developmental Biology and Gene Regulation
- Marine Invertebrate Physiology and Ecology
- Marine Ecology and Invasive Species
- Echinoderm biology and ecology
- Coral and Marine Ecosystems Studies
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Marine Sponges and Natural Products
- Planarian Biology and Electrostimulation
- Aquaculture disease management and microbiota
- Pluripotent Stem Cells Research
- Protist diversity and phylogeny
- Genetic and Kidney Cyst Diseases
- Legal Systems and Judicial Processes
- Geological Studies and Exploration
- Marine and coastal plant biology
- Genomics and Phylogenetic Studies
- Supramolecular Self-Assembly in Materials
- Renal and related cancers
- Geological and Geochemical Analysis
- Pasture and Agricultural Systems
- Cleft Lip and Palate Research
- CRISPR and Genetic Engineering
- Joseph Conrad and Literature
- Marine Biology and Ecology Research
University of North Carolina Wilmington
2020-2024
Louisiana State University Agricultural Center
2021
Broome-Tioga Board of Cooperative Educational Services
2021
Inserm
2015-2020
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2015-2020
Centre National de la Recherche Scientifique
2015-2020
Université Côte d'Azur
2018-2020
Duke University
2009-2016
Institut thématique Génétique, génomique et bioinformatique
2013
Cnidarians, the extant sister group to bilateria, are well known for their impressive regenerative capacity. The sea anemone Nematostella vectensis is a well-established system study of development and evolution that receiving increased attention its able regrow missing body parts within five six days after bisection, yet studies describing morphological, cellular, molecular events underlying this process sparse very heterogeneous in experimental approaches. In study, we lay down basic...
ABSTRACT For over a century, researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically difficult one to investigate because the best model systems are poor models vice versa. Recently, however, there renewed interest in this question, as emerging allowed these processes same organism. further fueled by advent of high-throughput transcriptomic analyses provide...
Abstract The painted urchin Lytechinus pictus is a sea in the family Toxopneustidae and one of several species that are routinely used as an experimental research organism. Recently, L. has emerged tractable model system for establishing transgenic lines due to its amenability long term laboratory culture. We present first published genome pictus. This chromosomal-level assembly was generated using Illumina sequencing conjunction with Oxford Nanopore Technologies read HiC chromatin...
ABSTRACT Sea urchins are premier model organisms for the study of early development. However, lengthy generation times commonly used species have precluded application stable genetic approaches. Here, we use painted sea urchin Lytechinus pictus to address this limitation and generate a homozygous mutant line. L. has one shortest any currently urchin. We leveraged advantage knockout homolog drug transporter ABCB1, major player in xenobiotic disposition all animals. Using CRISPR/Cas9,...
A relatively small number of signaling pathways govern the early patterning processes metazoan development. The architectural changes over time to these offer unique insights into their evolution. In case Hedgehog (Hh) signaling, two very divergent mechanisms pathway transduction have evolved. vertebrates, relies on trafficking Hh components nonmotile specialized primary cilia. contrast, protostomes do not use cilia any kind for signal transduction. How lineages adapted such dramatically...
Abstract For over a century, researchers have been trying to understand the relationship between embryogenesis and regeneration. A long-standing hypothesis is that biological processes implicated in embryonic development are re-deployed during In past decade, we begun relationships of genes their organization into gene regulatory networks (GRN) driving regeneration diverse taxa. Here, compare GRNs same species investigate how re-uses genetic interactions originally set aside for development....
Bilateral animals, including humans and most metazoans, are not perfectly symmetrical. Some internal structures distributed asymmetrically to the right or left side. A conserved Nodal BMP signaling system directs molecular pathways that impart sidedness those asymmetric structures. In sea urchin embryo, one such asymmetrical structure, oddly enough, is entire adult, which grows out of sided produced in larva. a paper just published PLOS Biology, shown be necessary early larval development...
Marine sponges play important roles in benthic ecosystems. More than providing shelter and food to other species, they help maintain water quality by regulating nitrogen ammonium levels the water, bioaccumulate heavy metals. This system, however, is particularly sensitive sudden environmental changes including catastrophic pollution event such as oil spills. Hundreds of platforms are currently actively extracting gas Gulf Mexico. To test vulnerability ecosystems spills, we utilized Caribbean...
Summary The sea urchin is a penta‐radial marine invertebrate of the phylum Echinodermata, yet urchins develop initially as bilaterally symmetric embryos and become secondarily during development adult. Late in embryogenesis indirectly developing larvae produce molecular asymmetries that dictate positioning formation adult rudiment on left side. gives rise to radially metamorphosis. mechanism left–right (L–R) establishment involves highly conserved signaling pathways including Nodal, BMP,...
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Abstract For more than a century researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically difficult one to investigate since the best model systems are poor models vice versa. Recently however, comparison of seen renewed interest as emerging including sea anemone Nematostella vectensis allowed these processes in same organism. further fueled by advent...
In 1975, the Education for All Handicapped Children Act (renamed Individuals with Disabilities in 1990) established essential obligation of special education law, which is to develop a student’s individualized program that enables them receive free appropriate public (FAPE). FAPE was defined federal law as and related services that: (a) are provided at expense, (b) meet standards state agency, (c) include preschool, elementary, or secondary education, (d) conformity (IEP). Thus, IEP...
Abstract The Antarctic sea urchin Sterechinus neumayeri (Echinoida; Echinidae) is routinely used as a model organism for biology. Here, we present high-quality genome of S. neumayeri. This chromosomal-level assembly was generated using PacBio long-read sequencing and Hi-C chromatin conformation capture sequencing. 885.3-Mb exhibits high contiguity with scaffold length N50 36.7 Mb assembled into 20 chromosomal scaffolds. These putative chromosomes exhibit degree synteny compared to other...
Marine sponge transcriptomes are underrepresented in current databases. Furthermore, only two genomes available for comparative studies. Here we present the assembled and annotated holo-transcriptome of common Florida reef from species Cinachyrella alloclada. After Illumina high throughput sequencing, data using Trinity v2.5 confirmed a highly symbiotic organism, with complexity microbial abundance (HMA) sponges. This dataset is enriched poly-A selected eukaryotic, rather than transcripts....
Abstract Cnidarians have become valuable models for understanding many aspects of developmental biology including the evolution body plan diversity, novel cell type specification, and regeneration. Most our gene function during early development in cnidarians comes from a small number experimental systems sea anemone, Nematostella vectensis . Few molecular tools been developed use hard corals, limiting this diverse ecologically important clade. Here, we report suite manipulating analyzing...