A5031330301- Ophthalmology and Visual Impairment Studies
- Tissue Engineering and Regenerative Medicine
- Traumatic Ocular and Foreign Body Injuries
- Urban Green Space and Health
- Mesenchymal stem cell research
- Congenital heart defects research
- Intraocular Surgery and Lenses
- Aortic aneurysm repair treatments
- Retinal Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Aortic Disease and Treatment Approaches
- Traumatic Brain Injury Research
- Telemedicine and Telehealth Implementation
- Cardiac Arrest and Resuscitation
- Migraine and Headache Studies
- Gaze Tracking and Assistive Technology
- Hallucinations in medical conditions
- Electrospun Nanofibers in Biomedical Applications
- Inclusion and Disability in Education and Sport
- Ocular Infections and Treatments
- Urban Transport and Accessibility
- COVID-19 and Mental Health
- Tactile and Sensory Interactions
Northumbria University
2021-2025
Royal National Institute of Blind
2024
University College London
2013-2024
National Hospital for Neurology and Neurosurgery
2024
University of Nebraska–Lincoln
2023
Universidade Federal do Pará
2018
Instituto Evandro Chagas
2018
Jena University Hospital
2018
Instituto Nacional do Câncer
2018
King's College London
2013-2017
Abdominal aortic aneurysms constitute a degenerative process in the wall. Both miR-29 and miR-15 families have been implicated regulating vascular extracellular matrix.Our aim was to assess effect of family on aneurysm development.Among members, miR-195 differentially expressed aortas apolipoprotein E-deficient mice angiotensin II infusion. Proteomics analysis secretome murine smooth muscle cells, after manipulation, revealed that targets cadre matrix proteins, including collagens,...
Endogenous cardiac progenitor cells, expanded from explants via cardiosphere formation, present a promising cell source to prevent heart failure following myocardial infarction. Here we used cine-magnetic resonance imaging (MRI) track administered cardiosphere-derived cells (CDCs) and measure changes in function over four months the infarcted rat heart.CDCs, cultured neonatal heart, comprised heterogeneous population including expressing mesenchymal markers CD90 CD105, stem marker c-kit...
Background: There has been growing concern about the impact of restrictions put in place to contain coronavirus pandemic on loneliness, particularly individuals with disabilities. This study explored longitudinal loneliness these individuals, a focus those living visual impairment (VI). Methods: An online survey was conducted April-2020 and repeated March 2021 explore current life circumstances, health-related behaviours, sleep (Pittsburgh Sleep Quality Index) social well-being, including...
Visual impairment has been associated with mental and physical comorbidities in older adults. Research into within minority ethnic communities (MEC) visual is yet to be explored, despite the increase numbers. A secondary analysis of survey data collected by UK-based sight loss charities provides first insight comorbid conditions a matched control sample 77 MEC White adults aged 18–85 years. Participants were based on age, gender, UK region, urban/rural setting. Group differences subgroup was...
Background/Aims Charles Bonnet syndrome (CBS) is a common complication of visual impairment. However, demographic and clinical characteristics may modify the prevalence impact condition. The aim was to investigate CBS among visually impaired military veterans associated hallucinations. Methods Cross-sectional screening survey study members at Blind Veterans UK, national charity supporting ex-armed forces men women with registered Data were analysed using membership records followed by...
Herein, we report the use of biodegradable nanoparticles (NPs) containing perfluoro-1,5-crown ether (PFCE), a fluorine-based compound (NP170-PFCE) with capacity to track cells in vivo by magnetic ressonance imaging (MRI) and efficiently release miRNA. NP170-PFCE complexed miRNAs accumulate whitin cell's endolysosomal compartment interact higher frequency argonaute2 (Ago2) GW182 proteins, which are involved biological action miRNAs, than commercial complexes formed reagents miRNA, turn cell...
Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising candidate cell source for infarcted myocardium regeneration. However, current protocols used to expand CDCs require at least 1 month in vitro obtain sufficient transplantation. We report that CDC culture optimized by preconditioning the under hypoxia (2% oxygen), may reflect physiological oxygen level of stem niche. Under hypoxia, proliferation rate increased 1.4-fold, generating 6 × 10 with higher...
War and conflict are global phenomena, identified as stress-inducing triggers for epigenetic modifications. In this state-of-the-science narrative review based on systematic principles, we summarise existing data to explore the outcomes of these exposures especially in veterans show that they may result an increased likelihood developing gastrointestinal, auditory, metabolic circadian issues, well post-traumatic stress disorder (PTSD). We also note that, despite a potential “healthy soldier...
As a minority within minority, individuals who have disability and identify as LGBT are at the intersection of multiple stigmatised identities. This brings with it unique challenges, including possibility oppression rejection by both communities, which can impact on identity wider life experiences. While previous reviews explored issues relating to intersectionality, oppression, identity, acceptance, sexuality, an overview experiences is missing. narrative review presents empirical findings...
Telerehabilitation for individuals with vision impairment aims to maintain maximum physical and/or psychological functioning through remote service delivery. This review describe the type of telerehabilitation services available people and summarise evidence on health-related outcomes, well-being cost-effectiveness.
To be clinically relevant as a therapy for heart failure, endogenous progenitor cells must isolated and expanded from aged and/or diseased tissue. Here, we investigated the effect of age cardiac impairment resulting lack dystrophin on murine cardiosphere-derived (CDCs). CDCs were atrial biopsies wild-type mice 1.5, 6, 18, 24 months mdx 6 18 months. Cardiac function was measured in age-matched using high-resolution cine magnetic resonance imaging. could all mice, however, number obtained,...
Hypoxia is a consequence of cardiac disease and downregulates mitochondrial metabolism, yet the molecular mechanisms through which this occurs in heart are incompletely characterized. Therefore, we aimed to use contracting HL-1 cardiomyocyte model investigate effects hypoxia on metabolism. Cells were exposed (2% O 2 ) for 6, 12, 24, 48 hours characterize metabolic response. subsequently treated with inducible factor (HIF)-activating compound, dimethyloxalylglycine (DMOG), determine whether...
To establish a permanent piwi like RNA-mediated gene silencing 1 (PIWIL1) knockout in AGP01 gastric cancer cell line using CRISPR-Cas9 system and analyze phenotypic modifications as well expression alterations.CRISPR-Cas9 used was purchased from Dharmacon GE Life Sciences (Lafayette, CO, United States) performed according to manufacturer's recommendations. Wound-healing assay investigate the effect of PIWIL1 on migration capability cells Boyden chamber invasion capability. For analysis,...
The adult human myocardium is incapable of regeneration; yet, the zebrafish (Danio rerio) can regenerate damaged myocardium. Similar to heart, hearts neonatal, but not mice are capable myocardial regeneration. We performed a proteomics analysis and compared their protein expression profile from neonatal mice. Using difference in-gel electrophoresis (DIGE), there was little overlap between proteome mouse (>8weeks old) (18months hearts. Similarly, significant degree mismatch in Enrichment...
To investigate the effects of age and disease on endogenous cardiac progenitor cells, we obtained right atrial left ventricular epicardial biopsies from patients (n = 22) with chronic ischaemic heart measured doubling time surface marker expression in explant- cardiosphere-derived cells (EDCs, CDCs). EDCs could be expanded all biopsy samples, but sufficient for cardiosphere culture were only 8 22 biopsies. both atrium ventricle contained a higher proportion c-kit+ than CDCs, which few such...
Significant progress has been made in the development of autonomous vehicles (AV) recent years, with an increasing number trials performed to identify how AVs might function within existing transport modal choices. With this come recognition multiple benefits that provide for wider society, not least reduced road congestion and pollution, safer travel, increased fuel efficiency. Removing need a dedicated driver means costs use services will be lower; case private AV ownership, requirement...
Background: Research exploring the impact of COVID-19 pandemic on sleep in people with disabilities has been scarce. This study provides a preliminary assessment disabilities, across two timepoints during pandemic, focus those visual impairment (VI). Methods: Two online surveys were conducted between April 2020 and March 2021 to explore quality using Pittsburgh Sleep Quality Index (PSQI). A convenience sample 602 participants completed first survey 160 follow-up survey. Results: Across both...
Dual sensory impairment (DSI) is prevalent in the older population, but due to exposure military-related risk factors, it a particular problem for veterans, and younger. This rapid review aimed critically summarise prevalence of DSI military veteran populations, as well any associative factors outcomes that were assessed. was done accordance with Preferred Reporting Items Systematic Reviews (PRISMA) statement. Several databases (Scopus, Web Science, AMED, CINAHL Plus, Ultimate, MEDLINE via...
Visual impairment (V.I.) has been associated with a negative impact on activities of daily living (ADL) and navigation outside the home. Adults from minority ethnic communities are projected to make up an increasing proportion V.I. population in UK, yet evidence relating their experiences is limited. This article uses data collected by Lives Survey, between December 2019 November 2020. Using secondary analysis anonymised survey data, this explores self-reported functioning ADL, home, use...